| Main Title |
Compatibility of Organic Solvents with the Microscreen Prophage-Induction Assay: Solvent - Mutagen Interactions. |
| Author |
DeMarini, D. M. ;
Lawrence, B. K. ;
Brooks, H. G. ;
Houk., V. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Durham, NC. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/164; |
| Stock Number |
PB91-231324 |
| Additional Subjects |
Mutagens ;
Organic solvents ;
Toxicity ;
Phage lambda ;
Mutagenicity tests ;
Escherichia coli ;
Metabolic activation ;
Hexanes ;
Acetone ;
Benzene ;
Chloroform ;
Ethyl alcohol ;
Propyl alcohol ;
Carbinols ;
Toluene ;
Xylenes ;
Chloromethanes ;
Dimethyl sulfoxide ;
Reprints ;
Aminoanthracenes ;
Nitrofluorenes
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-231324 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The following solvents did not induce prophage lambda in the Escherichia coli WP2 lambda Microscreen assay: acetone, benzene, chloroform, ethanol, n-hexane, isopropanol, methanol, toluene, and a mixture of the three isomers of xylene. Dimethyl sulfoxide was genotoxic in the presence and absence of S9, and methylene chloride was weakly genotoxic in the presence of S9. The genotoxic potencies of 2-aminoanthracene and 2-nitrofluorene were reduced when dissolved in DMSO or methanol compared to their potencies when dissolved in acetone. (Copyright (c) 1991 Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Mutation Research, v263 p107-113 1991. Prepared in cooperation with Environmental Health Research and Testing, Inc., Durham, NC. |
| Title Annotations |
Reprint: Compatibility of Organic Solvents with the Microscreen Prophage-Induction Assay: Solvent - Mutagen Interactions. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
128229576 |
| Origin |
NTIS |
| Type |
CAT |
