| Main Title |
Health assessment document for acrylonitrile : final report. |
| Author |
Basu, D. K. ;
Hsu, R. S. ;
Neal, M. W. ;
Santodonato, J. ;
Sugatt, R. H.
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, |
| Year Published |
1984 |
| Report Number |
EPA 600/8-82/007F; PB84149152 |
| Stock Number |
PB84-149152 |
| OCLC Number |
12713619 |
| Subjects |
Acrylonitrile--Toxicology ;
Air--Pollution--Physiological effect--United States ;
Carcinogens ;
Air--Pollution--United States--Physiological effect
|
| Additional Subjects |
Acrylonitriles ;
Toxicology ;
Nitriles ;
Physical properties ;
Chemical properties ;
Sampling ;
Sources ;
Residues ;
Transport ;
Distribution ;
Exposure ;
Concentration(Composition) ;
Humans ;
Laboratory animals ;
Air quality ;
Analytical methods ;
Biological effects ;
Toxic substances
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
EPA 600/8-82/007F |
|
Region 1 Library/Boston,MA |
05/25/2016 |
| ELBD ARCHIVE |
EPA 600-8-82-007F |
|
AWBERC Library/Cincinnati,OH |
05/25/2022 |
| ERAD |
EPA-600/8-82-007F |
|
Region 9 Library/San Francisco,CA |
05/17/1991 |
| NTIS |
PB84-149152 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : illustrations ; 28 cm |
| Abstract |
Acute acrylonitrile intoxication in humans, like many volatile organic compounds, results in irritation of the eyes and nose, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea, and convulsions. Unlike many of these other organics, acrylonitrile causes severe burns upon contact with the liquid chemical. Some significant functional disorders of the liver and kidney are observed under subchronic exposure conditions; while chronic exposure results in signs (unthrifty appearance, weight loss and early death) that may be related to the low food and water consumption resulting from the unpleasant taste of acrylonitrile in water. Pathological changes in rats believed to be treatment related include hyperplasia and hyperkeratosis of the squamous cells in the brain and mammary gland hyperplasia in females. The present data base from human and toxicologic studies provides enough evidence such that the International Agency for Research on Cancer (IARC) has characterized acrylonitrile as an animal carcinogen and a likely human carcinogen. Unlike the animal bioassay data, the human data base does not unequivocally demonstrate a causal association. |
| Notes |
"Research and development"--Cover "October 1983." Includes bibliographical references (pages R-1-24). "EPA-600/8-82-007F." Microfiche. |
| Place Published |
Research Triangle Park, NC |
| Supplementary Notes |
See also PB83-129593. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Environmental Criteria and Assessment Office (Research Triangle Park, N.C.) |
| PUB Date Free Form |
1984 |
| BIB Level |
m |
| Medium |
microform |
| Content |
text |
| Carrier |
microfiche |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20160419144054 |
| Language |
eng |
| SUDOCS Number |
EP 1.23/9:600/8-82-007 F |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01711cam 2200373Ia 45020 |
