| Main Title |
Induction of Anchorage-Independent Growth in Human Diploid Fibroblasts by the Cyclopenta-polycyclic Aromatic Hydrocarbon, Benz(1)-aceanthrylene. |
| Author |
Nesnow, S. ;
Milo, G. ;
Kurian, P. ;
Sangaiah, R. ;
Gold., A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Ohio State Univ., Columbus. Dept. of Physiological Chemistry. ;North Carolina Univ. at Chapel Hill. School of Public Health. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/165; |
| Stock Number |
PB91-115857 |
| Additional Subjects |
Toxicology ;
Aromatic polycyclic hydrocarbons ;
Carcinogens ;
Fibroblasts ;
Humans ;
Reprints ;
Environmental pollutants ;
Diploids ;
Benzolaceanthrylene ;
Mutagenicity tests ;
Cultured cells ;
Species specificity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-115857 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Cyclopenta-fused polycyclic aromatic hydrocarbons are a class of environmental PAH that has been recently identified. Many of these chemicals have been found to be more active that benzo(a)pyrene in tests for genetic toxicity using bacterial and rodent cells. Benz(l)aceanthrylene, a cyclopenta-polycyclic aromatic hydrocarbon related to benz(a)anthracene, and benzo(a)pyrene were compared for their activity to induce cytotoxicity and anchorage independent colony formation with normal human diploid fibroblasts. Both benz(l)aceanthrylene and benzo(a)pyrene were relatively non-cytotoxic to normal human diploid fibroblasts. However, benz(l)aceanthrylene was twice as active compared to benzo(a)pyrene over the concentration range examined as an inducer of anchorage independent growth. The ability of benz(l)aceanthrylene to induce anchorage independent colony growth in normal human cells in combination with its demonstrated ability as a mouse skin tumorigen suggests this PAH to be a potential multi-species carcinogen. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division.) |
| Supplementary Notes |
Pub. in Mutation Research, v244 n7 p221-225 Jul 90. Prepared in cooperation with Ohio State Univ., Columbus. Dept. of Physiological Chemistry, and North Carolina Univ. at Chapel Hill. School of Public Health. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Induction of Anchorage-Independent Growth in Human Diploid Fibroblasts by the Cyclopenta-polycyclic Aromatic Hydrocarbon, Benz(1)-aceanthrylene. |
| Category Codes |
57Y; 57F; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123295 |
| Origin |
NTIS |
| Type |
CAT |
