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Main Title Genotoxicity and Identification of the Major DNA-Adducts of Aceanthrylene.
Author Nesnow, S. ; Ross, J. ; Mohapatra, N. ; Gupta, R. ; Sangaiah, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Baylor Coll. of Medicine, Houston, TX. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.
Year Published 1988
Report Number EPA/600/D-88/026;
Stock Number PB88-170071
Additional Subjects Toxicology ; Deoxyribonucleic acids ; Identification ; Genotoxicity ; Aceanthrylene ; Salmonella typhimurium
Library Call Number Additional Info Location Last
NTIS  PB88-170071 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract Aceanthrylene (ACE), a cyclopenta-fused polycyclic aromatic hydrocarbon (CP-PAH) derivative of anthracene has been shown to be highly mutagenic in Salmonella typhimurium strain TA98 (1). C3H10T1/2CL8 (C3H10T1/2) mouse embryo fibroblasts have been used to study the metabolism and morphological transforming ability of PAH and several CP-PAH (2-5). The CP-PAH, cyclopenta(cd)pyrene and three of the four possible cyclopenta-benz(a)anthracene isomers were active in morphologically transforming C3H10T1/2 cells. Cyclopenta(cd)pyrene and two of the four possible isomers of cyclopenta-benz(a)anthracene, benz(j)aceanthrylene, and benz(l)aceanthrylene, were metabolized by C3H10T1/2 cells to dihydrodiol metabolites including cyclopenta-ring dihydrodiols. The study examines the ability of ACE, the smallest linear-fused CP-PAH yet examined, to be metabolized, to form DNA adducts, and to induce morphological transformation in C3H10T1/2 mouse embryo fibroblasts.
Supplementary Notes Prepared in cooperation with Baylor Coll. of Medicine, Houston, TX., and North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.
PUB Date Free Form Feb 88
Category Codes 57Q; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 812722283
Origin NTIS
Type CAT