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OLS Field Name OLS Field Data
Main Title Dermal Absorption and Disposition of 1,3-Diphenylguanidine in Rats.
Author Shah, P. V. ; Sumler, M. R. ; Ioannou, Y. M. ; Fisher, H. L. ; Hall, L. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/226;
Stock Number PB86-118494
Additional Subjects Skin(Anatomy) ; Toxicology ; Rats ; Laboratory animals ; Absorption ; Distribution ; Metabolism ; Pathology ; Reprints ; Guanidine/diphenyl
Library Call Number Additional Info Location Last
NTIS  PB86-118494 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 12p
Abstract Dermal absorption, distribution, and metabolism of 1,3-diphenylguanidine (DPG), widely used as an accelerator in processing rubbers and in food packaging, was studied in adult female Sprague-Dawley rats. DPG shows 10% penetration through clipped back skin of the rats in 5 days. The first-order dermal absorption rate constant as determined by least square method was 0.021 + or - 0.002 days-1 (T 1/2 = 33.6 days). Approximately 13% of the absorbed dose remained in the body in 5 days. Retention in skin, muscle, liver, intestine and fat contributed most to the body burden of DPG-derived radioactivity in 5 days. All tissues showed tissue to blood ratios greater than 1, with liver and intestine ratios of 26 at 5 days. Approximately 61% of the absorbed dose was eliminated into urine and 27% into feces in 5 days, showing rapid clearance of absorbed DPG from the body. HPLC analysis of urine revealed two major peaks (parent compound and metabolite(s)). Within 72 hr, approximately 50% of the DPG-derived radioactivity excreted in the urine was parent compound.
Supplementary Notes Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Availability Notes Pub. in Jnl of Toxicology and Environmental Health 15, n5 p623-633 Oct 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Dermal Absorption and Disposition of 1,3-Diphenylguanidine in Rats.
PUB Date Free Form c1985
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 603115744
Origin NTIS
Type CAT