Main Title |
The mechanism of sulfur dioxide initiated bronchoconstriction / |
Author |
Charles, Jeffrey M. ;
Menzel., Daniel B.
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Other Authors |
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CORP Author |
Duke Univ. Medical Center, Durham, N.C. Lab. of Environmental Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, N.C. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
Year Published |
1977 |
Report Number |
EPA-600/1-77-046; EPA-68-02-1794; PB275713 |
Stock Number |
PB 275 713 |
OCLC Number |
52418644 |
Additional Subjects |
Sulfur dioxide ;
Sulfates ;
Lung ;
Respiratory system ;
Particles ;
Respiration ;
Bonchi ;
Absorption(Biology) ;
Pathophysiology ;
Histamines ;
In vitro analysis ;
Guinea pigs ;
In vivo analysis ;
Rats ;
Laboratory animals ;
Clearances ;
Ammonium sulfate ;
Experimental data ;
Physiological effect ;
Toxicology ;
Air pollution effects(Animals) ;
Synergism ;
Irritant compounds ;
Environmental health
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Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-77-046 |
|
Headquarters Library/Washington,DC |
05/19/2014 |
EKBD |
EPA-600/1-77-046 |
|
Research Triangle Park Library/RTP, NC |
06/13/2003 |
ELBD ARCHIVE |
EPA 600-1-77-046 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD RPS |
EPA 600-1-77-046 |
repository copy |
AWBERC Library/Cincinnati,OH |
07/07/2016 |
NTIS |
PB-275 713 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
xiv, 109 pages : illustrations ; 28 cm. |
Abstract |
Atmospheric sulfur oxides exist in chemically complex particulates of the respirable size range. Inhalation of these particulates represents a potential health hazard. This report provides the results of a series of experiments into the uptake of sulfate salts by the lung, the interaction of sulfate salts with specific hormonal systems in the lung and the potential interrelations between sulfate and heavy metal aerosols as they might exist in the environment. The data reported describe for the first time the uptake and elimination kinetics of sulfate ion in mammalian lungs. The release of histamine by sulfate salts is demonstrated as a potential mechanism of action and as a means by which the varying potency of different chemical salts of sulfuric acid may be explained. In sum, these studies illustrate that sulfate aerosols can not be considered independent of the other inorganic compounds found in respirable particles. |
Notes |
"Project Officer: Donald E. Gardner." Duke University Medical Center "October 1977." "EPA-600/1-77-046." Includes bibliographical references. |