Record Display for the EPA National Library Catalog
RECORD NUMBER: 23 OF 502
|OLS Field Name||OLS Field Data|
|Main Title||Application of Pharmacokinetic Models to Predict Target Dose (Chapter 2).|
|Author||Blancato, J. N. ; Bishoff, K. B. ;|
|CORP Author||Environmental Monitoring Systems Lab., Las Vegas, NV. ;Delaware Univ., Newark.|
|Additional Subjects||Pharmacokinetics ; Models ; Risk assessment ; Public health ; Pharmacology ; Dosage ; Health risks ; Physiology ; Chemical compounds ; Flow distribution ; Metabolism ; Toxicity ; Research and development ; Membranes ; Environmental monitoring ; Reprints ; Micropharmacokinetic models|
The number of new and old chemical compounds to which the human race is exposed has quickly become astronomical. Methods of risk assessment have been slow to develop. Industry, government and academia have had to scrupulously examine the benefits-to-cost ratio of these studies. The limiting factors appear to be the questions of extrapolation and the compatibility of different metabolic processes in different species. The chapter discusses (1) pharmacokinetics, (2) model development, (3) flow-limited assumptions, (4) membrane-limited assumption, (5) micropharmacokinetic physiologic models and their implementation.