Record Display for the EPA National Library Catalog


Main Title Quantitative and Temporal Relationships between DNA Adduct Formation in Target and Surrogate Tissues: Implications for Biomonitoring.
Author Nesnow, S. ; Ross, J. ; Nelson, G. ; Holden, K. ; Erexson., G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Kentucky Univ., Lexington. Dept. of Preventive Medicine and Environmental Health.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/212;
Stock Number PB94-163912
Additional Subjects DNA adducts ; Environmental carcinogens ; Time factors ; Lung ; Liver ; Benzo(a)pyrene ; Lymphocytes ; Humans ; Reprint ; Biological monitoring ; Benzo(b)fluoranthene
Library Call Number Additional Info Location Last
NTIS  PB94-163912 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
DNA-carcinogen adducts offer a potential dosimeter for environmental genotoxicants reaching the exposed individual. Because the target tissues for many chemical carcinogens are not readily accessible for monitoring adducts in humans, peripheral blood lymphocytes (PBLs) have served as surrogate sources of exposed DNA. Both benzo(a)pyrene (B(a)P) and benzo(b)fluoranthene (B(b)F) are widely distributed in the environment as components of complex mixtures, such as automobile exhaust, cigarette smoke, foods, water, and urban air. Thus, human exposure to these chemicals is widespread, and they probably contribute to overall human lung cancer risk. The interpretation of the results of such studies would be enhanced by an understanding of the pharmacokinetics of specific DNA adduct formation and persistence in both target and surrogate tissues.