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Main Title Correlation of Carcinogenic Potency with Mouse-Skin (32)P-Postlabeling and Muta-(R)Mouse lac Z(-)Mutation Data for DMBA and Its K-Region Sulphur Isostere: Comparison with Activities Observed in Standard Genotoxicity Assays.
Author Ashby, J. ; Brusick, D. ; Myhr, B. C. ; Jones, N. J. ; Parry, J. M. ;
CORP Author ZENECA Central Toxicology Lab., Cheshire (England). ;University Coll. of Swansea (Wales). School of Biological Sciences. ;Pittsburgh Univ., PA. Graduate School of Public Health. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pittsburgh Univ., PA. Graduate School of Public Health.;Environmental Protection Agency, Research Triangle Park, NC. Carcinogenesis and Metabo
Publisher c1993
Year Published 1993
Report Number EPA-68-02-4456; EPA/600/J-94/062;
Stock Number PB94-143732
Additional Subjects Carcinogens ; Skin diseases ; Toxicity ; Mice ; Polyaromatic hydrocarbons ; Assaying ; Salmonella ; Mutations ; DNA ; Risk assessment ; Genetics ; Artificial intelligence ; Expert systems ; In vitro analysis ; In vivo analysis ; Reprints ; S-DMBA(6 11-Dimethylbenzo(b)naphtho(2 3-d)thiopene) ; DMBA(7 12-Dimethylbenz(a)anthracene) ; MULTICASE
Library Call Number Additional Info Location Last
NTIS  PB94-143732 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) have been compared with those of its weakly carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo(b)naphtho-(2,3-d)thiophene (S-DMBA). The only datasets that correlated with the relative carcinogenicity of these agents to the skin were those conducted using topically exposed mouse skin. Thus, both chemicals induced lacZ(-) mutations in the skin of lacZ(+) transgenic mice, and both produced DNA adducts on mouse-skin DNA as assessed using the (sup 32) P-postlabeling technique. The molecular geometry of DMBA and S-DMBA are compared, and divergent CASE predictions of activity in the Salmonella assay and skin-painting bioassay are discussed. (Copyright (c) 1993 Elsevier Science Publishers B.V.)