Main Title |
Correlation of Carcinogenic Potency with Mouse-Skin (32)P-Postlabeling and Muta-(R)Mouse lac Z(-)Mutation Data for DMBA and Its K-Region Sulphur Isostere: Comparison with Activities Observed in Standard Genotoxicity Assays. |
Author |
Ashby, J. ;
Brusick, D. ;
Myhr, B. C. ;
Jones, N. J. ;
Parry, J. M. ;
|
CORP Author |
ZENECA Central Toxicology Lab., Cheshire (England). ;University Coll. of Swansea (Wales). School of Biological Sciences. ;Pittsburgh Univ., PA. Graduate School of Public Health. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pittsburgh Univ., PA. Graduate School of Public Health.;Environmental Protection Agency, Research Triangle Park, NC. Carcinogenesis and Metabo |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA-68-02-4456; EPA/600/J-94/062; |
Stock Number |
PB94-143732 |
Additional Subjects |
Carcinogens ;
Skin diseases ;
Toxicity ;
Mice ;
Polyaromatic hydrocarbons ;
Assaying ;
Salmonella ;
Mutations ;
DNA ;
Risk assessment ;
Genetics ;
Artificial intelligence ;
Expert systems ;
In vitro analysis ;
In vivo analysis ;
Reprints ;
S-DMBA(6 11-Dimethylbenzo(b)naphtho(2 3-d)thiopene) ;
DMBA(7 12-Dimethylbenz(a)anthracene) ;
MULTICASE
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-143732 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
17p |
Abstract |
The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) have been compared with those of its weakly carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo(b)naphtho-(2,3-d)thiophene (S-DMBA). The only datasets that correlated with the relative carcinogenicity of these agents to the skin were those conducted using topically exposed mouse skin. Thus, both chemicals induced lacZ(-) mutations in the skin of lacZ(+) transgenic mice, and both produced DNA adducts on mouse-skin DNA as assessed using the (sup 32) P-postlabeling technique. The molecular geometry of DMBA and S-DMBA are compared, and divergent CASE predictions of activity in the Salmonella assay and skin-painting bioassay are discussed. (Copyright (c) 1993 Elsevier Science Publishers B.V.) |