Record Display for the EPA National Library Catalog


Main Title Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection.
Author Daniel, F. B. ; Olson, G. R. ; Stober, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Pathology Associates, Inc., Cincinnati, OH.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/123;
Stock Number PB92-164938
Additional Subjects Gastrointestinal system ; Mutations ; Chlorine ; Disinfection ; Cell nucleus ; Bioassay ; Carcinogens ; Mutagens ; Salmonella ; Epichlorhydrin ; Methylnitrosourea ; Micronucleus tests ; Reprints ; Furanones
Library Call Number Additional Info Location Last
NTIS  PB92-164938 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Two chlorinated hydroxylated furanones, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and 3,4-(dichloro)-5-hydroxy-2(5H)-furanone (MA), potent bacterial mutagens and by-products of chlorine disinfection, induce nuclear anomalies in the gastrointestinal tract of B6C3F1 mice. In this bioassay the two chlorohydroxyfuranones were approximately comparable to the epichlorohydrin (EPI), a known rodent gastrointestinal tract carcinogen but were much less potent than methylnitrosourea (MNU). The duodenum was the most sensitive tissue responding by both increased numbers of nuclear anomalies per mouse and increased incidence of animals presenting the aberrations 24 hours after a single oral dose of 0.38 and 0.46 mmol/kg of MX and MA respectively. The proximal colon responded to MX but not MA and neither compound produced increased nuclear anomalies in the forestomach. Although this is the first study demonstrating that chlorohydroxyfuranones are capable of inducing genotoxicity in vivo it is clear that their potency in the gastrointestinal tract nuclear anomalies assay is not comensurate with their extreme mutagenicity in Salmonella.