Record Display for the EPA National Library Catalog
RECORD NUMBER: 96 OF 432Main Title | Compatibility of Organic Solvents with the Microscreen Prophage-Induction Assay: Solvent - Mutagen Interactions. | |||||||||||
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Author | DeMarini, D. M. ; Lawrence, B. K. ; Brooks, H. G. ; Houk., V. S. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Durham, NC. | |||||||||||
Publisher | c1991 | |||||||||||
Year Published | 1991 | |||||||||||
Report Number | EPA/600/J-91/164; | |||||||||||
Stock Number | PB91-231324 | |||||||||||
Additional Subjects | Mutagens ; Organic solvents ; Toxicity ; Phage lambda ; Mutagenicity tests ; Escherichia coli ; Metabolic activation ; Hexanes ; Acetone ; Benzene ; Chloroform ; Ethyl alcohol ; Propyl alcohol ; Carbinols ; Toluene ; Xylenes ; Chloromethanes ; Dimethyl sulfoxide ; Reprints ; Aminoanthracenes ; Nitrofluorenes | |||||||||||
Holdings |
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Collation | 9p | |||||||||||
Abstract | The following solvents did not induce prophage lambda in the Escherichia coli WP2 lambda Microscreen assay: acetone, benzene, chloroform, ethanol, n-hexane, isopropanol, methanol, toluene, and a mixture of the three isomers of xylene. Dimethyl sulfoxide was genotoxic in the presence and absence of S9, and methylene chloride was weakly genotoxic in the presence of S9. The genotoxic potencies of 2-aminoanthracene and 2-nitrofluorene were reduced when dissolved in DMSO or methanol compared to their potencies when dissolved in acetone. (Copyright (c) 1991 Elsevier Science Publishers B.V.) |