Record Display for the EPA National Library Catalog


Main Title Health assessment document for acrylonitrile : final report.
Author Basu, D. K. ; Hsu, R. S. ; Neal, M. W. ; Santodonato, J. ; Sugatt, R. H.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1984
Report Number EPA 600/8-82/007F; PB84149152
Stock Number PB84-149152
OCLC Number 12713619
Subjects Acrylonitrile--Toxicology ; Air--Pollution--Physiological effect--United States ; Carcinogens ; Air--Pollution--United States--Physiological effect
Additional Subjects Acrylonitriles ; Toxicology ; Nitriles ; Physical properties ; Chemical properties ; Sampling ; Sources ; Residues ; Transport ; Distribution ; Exposure ; Concentration(Composition) ; Humans ; Laboratory animals ; Air quality ; Analytical methods ; Biological effects ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA 600/8-82/007F Region 1 Library/Boston,MA 05/25/2016
ELBD ARCHIVE EPA 600-8-82-007F AWBERC Library/Cincinnati,OH 05/25/2022
ERAD  EPA-600/8-82-007F Region 9 Library/San Francisco,CA 05/17/1991
NTIS  PB84-149152 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
Acute acrylonitrile intoxication in humans, like many volatile organic compounds, results in irritation of the eyes and nose, weakness, labored breathing, dizziness, impaired judgement, cyanosis, nausea, and convulsions. Unlike many of these other organics, acrylonitrile causes severe burns upon contact with the liquid chemical. Some significant functional disorders of the liver and kidney are observed under subchronic exposure conditions; while chronic exposure results in signs (unthrifty appearance, weight loss and early death) that may be related to the low food and water consumption resulting from the unpleasant taste of acrylonitrile in water. Pathological changes in rats believed to be treatment related include hyperplasia and hyperkeratosis of the squamous cells in the brain and mammary gland hyperplasia in females. The present data base from human and toxicologic studies provides enough evidence such that the International Agency for Research on Cancer (IARC) has characterized acrylonitrile as an animal carcinogen and a likely human carcinogen. Unlike the animal bioassay data, the human data base does not unequivocally demonstrate a causal association.
"Research and development"--Cover "October 1983." Includes bibliographical references (pages R-1-24). "EPA-600/8-82-007F." Microfiche.