Record Display for the EPA National Library CatalogRECORD NUMBER: 4 OF 10
|Main Title||Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection.|
|Author||Daniel, F. B. ; Schenck, K. M. ; Mattox, J. K. ; Lin, E. L. C. ; Haas, D. L. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Halogen organic compounds ; Acetonitriles ; Chlorination ; Water treatment ; Disinfection ; Public health ; Bioassay ; Carcinogens ; Hazards ; Toxicity ; Humans ; Cells(Biology) ; Exposure ; Reprints ; Drinking water ; Water pollution effects(Humans)|
Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl) pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, the authors have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.