Record Display for the EPA National Library Catalog


Main Title Approaches to risk assessment for multiple chemical exposures /
Author Stara, J. F. ; Erdreich, Linda S. ; Erdreich, L. S.
Other Authors
Author Title of a Work
Stara, J. F.
Erdreich, Linda S.
CORP Author United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.; Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.; Dynamac Corp., Rockville, MD.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1984
Report Number EPA-600/9-84-008
Stock Number PB84-182369
OCLC Number 10663121
Subjects Environmental health--United States ; Carcinogens ; Chemicals--United States ; Toxicology
Additional Subjects Environmental health--United States ; Carcinogens ; Chemicals--United States ; Chemical compounds ; Toxicology ; Environmental surveys ; Exposure ; Risk ; Assessments ; Mixtures ; Hazardous materials ; Mathematical models ; Industrial medicine ; Public health ; Humans ; Malignant neoplasms ; Toxic substances ; Cancer ; Occupational safety and health ; Pharmacokinetics ; Path of pollutants ; Threshold limit valves
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1216 EPA-6009-84-008 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA 600/9-84-008 OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/9-84-008 Research Triangle Park Library/RTP, NC 11/18/2005
EKCD  EPA-600/9-84-008 CEMM/GEMMD Library/Gulf Breeze,FL 09/24/2018
ELBD ARCHIVE EPA 600-9-84-008 AWBERC Library/Cincinnati,OH 09/30/2021
ERAD  EPA 600/9-84-008 Region 9 Library/San Francisco,CA 03/04/2013
ESAD  EPA 600-9-84-008 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB84-182369 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 277 pages : illustrations ; 28 cm
The Environmental Criteria and Assessment Office (ECAO) in Cincinnati has developed health risk assessment methods for chronic exposure to single chemical from a single route of exposure. Risk assessments for carcinogens associated an exposure level with a particular incidence of cancer using a non-threshold model which is linear at low doses. For systemic toxicants, the no-observed-adverse-effect level (NOAEL)/Uncertainty Factor approach was used to estimate an acceptable daily intake (ADI). In order to develop methods for assessing risk from exposure to mixtures of chemicals, all relevant routes and all exposure durations must be considered. The basis of the single chemical approach is constantly updated to keep pace with developments in pharmacokinetics, species and route extrapolation, mathematical models, additivity and interaction. These and other relevant issues were addressed during a 2-day workshop on 'Approaches to Risk Assessment for Multiple Chemical Exposures' held by the U.S. Environmental Protection Agency in Cincinnati, Ohio on September 29 and 30, 1982. The workshop was attended by 50 scientists from EPA and private industry. This document presents the results of this workshop, including presentations, critiques and discussion for each of the 11 subtopics covered.
Distributed to despository libraries in microfiche. "March 1984." Includes bibliographical references. "EPA-600/9-84-008."