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Main Title The mechanism of sulfur dioxide initiated bronchoconstriction /
Author Charles, Jeffrey M. ; Menzel., Daniel B.
Other Authors
Author Title of a Work
Menzel, Daniel B.
Gardner, Donald E.,
Gardner, Donald E., 1931-
CORP Author Duke Univ. Medical Center, Durham, N.C. Lab. of Environmental Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600/1-77-046; EPA-68-02-1794; PB275713
Stock Number PB 275 713
OCLC Number 52418644
Additional Subjects Sulfur dioxide ; Sulfates ; Lung ; Respiratory system ; Particles ; Respiration ; Bonchi ; Absorption(Biology) ; Pathophysiology ; Histamines ; In vitro analysis ; Guinea pigs ; In vivo analysis ; Rats ; Laboratory animals ; Clearances ; Ammonium sulfate ; Experimental data ; Physiological effect ; Toxicology ; Air pollution effects(Animals) ; Synergism ; Irritant compounds ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-77-046 Headquarters Library/Washington,DC 05/19/2014
EKBD  EPA-600/1-77-046 Research Triangle Park Library/RTP, NC 06/13/2003
ELBD ARCHIVE EPA 600-1-77-046 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 600-1-77-046 repository copy AWBERC Library/Cincinnati,OH 07/07/2016
NTIS  PB-275 713 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiv, 109 pages : illustrations ; 28 cm.
Atmospheric sulfur oxides exist in chemically complex particulates of the respirable size range. Inhalation of these particulates represents a potential health hazard. This report provides the results of a series of experiments into the uptake of sulfate salts by the lung, the interaction of sulfate salts with specific hormonal systems in the lung and the potential interrelations between sulfate and heavy metal aerosols as they might exist in the environment. The data reported describe for the first time the uptake and elimination kinetics of sulfate ion in mammalian lungs. The release of histamine by sulfate salts is demonstrated as a potential mechanism of action and as a means by which the varying potency of different chemical salts of sulfuric acid may be explained. In sum, these studies illustrate that sulfate aerosols can not be considered independent of the other inorganic compounds found in respirable particles.
"Project Officer: Donald E. Gardner." Duke University Medical Center "October 1977." "EPA-600/1-77-046." Includes bibliographical references.