Grantee Research Project Results
Publications Details for Grant Number R835165
Multi-Sensor Reporter Cell Technology to Assess Hazard Involving Endocrine Signaling Pathways
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Statistical validation of structured population models for Daphnia magna. | MATHEMATICAL BIOSCIENCES | Adoteye K, Banks HT, Cross K, Eytcheson S, Flores KB, LeBlanc GA, Nguyen T, Ross C, Smith E, Stemkovski M, Stokely S | Adoteye K, Banks HT, Cross K, Eytcheson S, Flores KB, LeBlanc GA, Nguyen T, Ross C, Smith E, Stemkovski M, Stokely S. Statistical validation of structured population models for Daphnia magna. Mathematical Biosciences 2015;266:73-84. |
R835165 (Final) |
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Journal Article | Estimation of time-varying mortality rates using continuous models for Daphnia magna. | APPLIED MATHEMATICS LETTERS | Adoteye K, Banks HT, Flores KB, LeBlanc GA | Adoteye K, Banks HT, Flores KB, LeBlanc GA. Estimation of time-varying mortality rates using continuous models for Daphnia magna. Applied Mathematics Letters 2015;44:12-16. |
R835165 (Final) |
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Journal Article | Agonist-mediated assembly of the crustacean methyl farnesoate receptor. | None | Kakaley EK, Wang HY, LeBlanc GA | Kakaley EK, Wang HY, LeBlanc GA. Agonist-mediated assembly of the crustacean methyl farnesoate receptor. Scientific Reports 2017;7:45071 (9 pp.). |
R835165 (Final) |
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Journal Article | Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids. | THE FEBS JOURNAL | LeBlanc GA, Medlock EK | LeBlanc GA, Medlock EK. Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids. The FEBS Journal 2015;282(21):4080-4093. |
R835165 (2015) R835165 (Final) |
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Journal Article | Ligand-mediated receptor assembly as an endpoint for high-throughput chemical toxicity screening. | None | Medlock Kakaley EK, Eytcheson SA, LeBlanc GA | Medlock Kakaley EK, Eytcheson SA, LeBlanc GA. Ligand-mediated receptor assembly as an endpoint for high-throughput chemical toxicity screening. Environmental Science & Technology 2017;51(16):9327-9333. |
R835165 (Final) |
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Journal Article | Continuous Structured Population Models for Daphnia magna | BULLETIN OF MATHEMATICAL BIOLOGY | Rutter E, Banks H, LeBlanc G, Flores K | Rutter E, Banks H, LeBlanc G, Flores K. Continuous Structured Population Models for Daphnia magna. BULLETIN OF MATHEMATICAL BIOLOGY 2017;79:2627-2648 |
R835165 (Final) |
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Journal Article | Differential interactions of the flame retardant triphenyl phosphate within the PPAR signaling network. | None | Wang Y, Kwon G, An L, Holmes CN, Haeba M, LeBlanc GA | Wang Y, Kwon G, An L, Holmes CN, Haeba M, LeBlanc GA. Differential interactions of the flame retardant triphenyl phosphate within the PPAR signaling network. MOJ Toxicology 2016;2(3):00039 (11 pp.). |
R835165 (Final) |
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Presentation | High-throughput assays to assess interactive effects of chemicals on endocrine signaling pathways. | None | An L, Ectcheson S, Holmes C, Kwon G, Medlock E, Wang Y | An L, Ectcheson S, Holmes C, Kwon G, Medlock E, Wang Y. High-throughput assays to assess interactive effects of chemicals on endocrine signaling pathways. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America Focus Topic Meeting: Endocrine Disruption, U.S. Environmental Protection Agency, Research Triangle Park, NC, February 4-6, 2014. |
R835165 (2015) R835165 (Final) |
not available |
Presentation | Integrating synergy into additive models of chemical mixtures toxicity. | None | Holmes CN, LeBlanc GA | Holmes CN, LeBlanc GA. Integrating synergy into additive models of chemical mixtures toxicity. Presented at the Carolinas Society of Environmental Toxicology and Chemistry (CSETAC) Annual Meeting, Raleigh, NC, March 2013. |
R835165 (Final) |
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Presentation | Insect growth-regulating insecticides differentially activates the PPAR signaling network. | None | Holmes CN, LeBlanc GA | Holmes CN, LeBlanc GA. Insect growth-regulating insecticides differentially activates the PPAR signaling network. Presented at the 53rd Annual Meeting of the Society of Toxicology, Phoenix, AZ, March 23-27, 2014. |
R835165 (Final) |
not available |
Presentation | Insect growth-regulating insecticides differentially activate the PPAR signaling network. | None | Holmes CN, LeBlanc GA | Holmes CN, LeBlanc GA. Insect growth-regulating insecticides differentially activate the PPAR signaling network. Presented at the 54th Annual Meeting of the Society of Toxicology, San Diego, CA, March 22-26, 2015 |
R835165 (2014) R835165 (2015) R835165 (Final) |
not available |
Presentation | Ligand-dependent receptor assembly as an endpoint for the high-throughput screening of chemicals for endocrine activity. | None | Holmes CN, Kwon G, Wang Y, An L, LeBlanc GA | Holmes CN, Kwon G, Wang Y, An L, LeBlanc GA. Ligand-dependent receptor assembly as an endpoint for the high-throughput screening of chemicals for endocrine activity. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835165 (2015) R835165 (Final) |
not available |
Presentation | Bioluminescence energy resonance transfer: an innovative technology for evaluating chemical interactions with nuclear receptors. | None | Holmes CN, Kwon G, Wang Y, An L, LeBlanc GA | Holmes CN, Kwon G, Wang Y, An L, LeBlanc GA. Bioluminescence energy resonance transfer: an innovative technology for evaluating chemical interactions with nuclear receptors. Presented at the Society of Toxicology Future Tox III Meeting, Arlington, VA, November 19-20, 2015. |
R835165 (2015) R835165 (Final) |
not available |
Presentation | Multi-sensor reporter cell technology to assess hazard involving endocrine signaling pathways. | None | LeBlanc GA | LeBlanc GA. Multi-sensor reporter cell technology to assess hazard involving endocrine signaling pathways. Presented at the U.S. Environmental Protection Agency, Washington DC, 2012. |
R835165 (2013) R835165 (Final) |
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Presentation | A transgenerational endocrine signaling pathway in crustacea. | None | LeBlanc GA, Wang YH, Holmes CN, Kwon G, Medlock EK | LeBlanc GA, Wang YH, Holmes CN, Kwon G, Medlock EK. A transgenerational endocrine signaling pathway in crustacea. Presented at the Carolinas Society of Environmental Toxicology and Chemistry (CSETAC) Meeting, Raleigh, NC, March 2013. |
R835165 (2012) R835165 (Final) |
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Presentation | Endocrine disruption beyond the estrogen, androgen, and thyroid signaling pathways. | None | LeBlanc GA | LeBlanc GA. Endocrine disruption beyond the estrogen, androgen, and thyroid signaling pathways. Presented via a webinar sponsored by the U.S. Environmental Protection Agency, Washington DC, 2013. |
R835165 (2013) R835165 (Final) |
not available |
Presentation | Sex on demand: environmental sex determination in crustacea. | None | LeBlanc GA | LeBlanc GA. Sex on demand: environmental sex determination in crustacea. Presented at the University of North Carolina at Wilmington, Wilmington, NC, 2013. |
R835165 (2013) R835165 (Final) |
not available |
Presentation | Emerging targets of endocrine disruption: the xenocrine system. | None | LeBlanc GA | LeBlanc GA. Emerging targets of endocrine disruption: the xenocrine system. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America Focused Topic Meeting: Endocrine Disruption, U.S. Environmental Protection Agency, Research Triangle Park, NC, February 4-6, 2014. |
R835165 (2013) R835165 (Final) |
not available |
Presentation | Reproductive and developmental signaling pathway in crustaceans. | None | Medlock EK, LeBlanc GA | Medlock EK, LeBlanc GA. Reproductive and developmental signaling pathway in crustaceans. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 34th Annual Meeting, Nashville, TN, November 17-21, 2013. |
R835165 (2012) |
not available |
Presentation | Activation of a sex determination signaling cascade in crustaceans. | None | Medlock EK, LeBlanc GA | Medlock EK, LeBlanc GA. Activation of a sex determination signaling cascade in crustaceans. Presented at the Carolinas Chapter of the Society of Environmental Toxicology and Chemistry (CSETAC) Annual Meeting, Clemson SC, April 2014. |
R835165 (2014) R835165 (Final) |
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Presentation | Activation and disruption of a crustacean reproductive signaling pathway. | None | Medlock EK, LeBlanc GA | Medlock EK, LeBlanc GA. Activation and disruption of a crustacean reproductive signaling pathway. Presented at the 35th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC) North America, Vancouver, British Columbia, Canada, November 9-13, 2014. |
R835165 (2014) R835165 (Final) |
not available |
Presentation | Males on demand: the environmental–neuro-endocrine control of male sex determination in daphnids. | None | Medlock EK | Medlock EK. Males on demand: the environmental–neuro-endocrine control of male sex determination in daphnids. Podcast presented via The FEBS Journal, August 26, 2015. |
R835165 (2015) R835165 (Final) |
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Presentation | Deciphering an environmental-endocrine signaling pathway for the identification of efficacious screening endpoints. | None | Medlock EK, LeBlanc GA | Medlock EK, LeBlanc GA. Deciphering an environmental-endocrine signaling pathway for the identification of efficacious screening endpoints. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015. |
R835165 (2015) R835165 (Final) |
not available |
Presentation | Bioluminescence resonance energy transfer (BRET) as an approach for high-throughput screening of chemicals for toxicity. | None | Medlock EK, LeBlanc GA | Medlock EK, LeBlanc GA. Bioluminescence resonance energy transfer (BRET) as an approach for high-throughput screening of chemicals for toxicity. Presented at the North Carolina State University Graduate Student Symposium, Raleigh, NC, 2015. |
R835165 (Final) |
not available |
Presentation | A novel approach for high-throughput screening of potential crustacean endocrine disrupting chemicals. | None | Medlock E, LeBlanc GA | Medlock E, LeBlanc GA. A novel approach for high-throughput screening of potential crustacean endocrine disrupting chemicals. Poster presented at the North Carolina State University 10th Annual Graduate Student Research Symposium, Raleigh, NC, March 25, 2015 (Poster No. 118). |
R835165 (2015) |
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Presentation | Novel modes of endocrine action and disruption. | None | LeBlanc GA | LeBlanc GA. Novel modes of endocrine action and disruption. Presented at the 6th Society of Environmental Toxicology and Chemistry (SETAC) Europe Special Science Symposium: Environmental Endocrine Disruptor Testing and Evaluation, Brussels, Belgium, October 24-25, 2012. |
R835165 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.