Grantee Research Project Results
Publications Details for Grant Number R834596C003
Ambient Pollutant/Bioaerosol Effects on Treg Function
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | How does diesel exhaust impact asthma? | THORAX | Balmes JR | Balmes JR. How does diesel exhaust impact asthma? Thorax 2011;66(1):4-6. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Journal Article | Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA. | JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY | Gale SL, Noth EM , Mann J, Balmes J, Hammond SK, Tager IB | Gale SL, Noth EM , Mann J, Balmes J, Hammond SK, Tager IB. Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA. Journal of Exposure Science & Environmental Epidemiology 2012;22(4):386-392. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Journal Article | Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. | CLINICAL & EXPERIMENTAL ALLERGY | Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC | Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. |
R834596 (2012) R834596 (Final) R834596C003 (Final) R834786 (Final) R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) |
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| Journal Article | Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. | None | Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K | Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics 2012;4(1):17 (16 pp.). |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) R834596C003 (Final) R834786 (2012) R835435 (Final) |
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| Journal Article | Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. | JOURNAL OF TOXICOLOGY | Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC | Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC. Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology 2013;2013:967029. |
R834596 (2012) R834596 (Final) R834596C003 (2012) R834596C003 (Final) R834786 (2012) R835435 (Final) |
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| Journal Article | Ambient air pollution impairs regulatory T-cell function in asthma. | None | Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I | Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. Journal of Allergy and Clinical Immunology 2010;126(4):845-852.e10. |
R834596 (2010) R834596 (2011) R834596C003 (2010) R834596C003 (2011) R834786 (2011) R835435 (Final) |
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| Presentation | Effects of air pollution on immune function and asthma. | None | Balmes J, Nadeau K, Mann J, Gale S, Noth E, Shaw G, Hammond SK, Tager I | Balmes J, Nadeau K, Mann J, Gale S, Noth E, Shaw G, Hammond SK, Tager I. Effects of air pollution on immune function and asthma. Presented at the Symposium on Children's Environmental Health Research, California EPA, Oakland, CA, January 11-12, 2012. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | The effect of chronic exposure to PAHs on lung function in children. | None | Balmes J, Padula A, Eisen E, Mann J, Noth E, Lurmann F, Nadeau K, Hammond SK | Balmes J, Padula A, Eisen E, Mann J, Noth E, Lurmann F, Nadeau K, Hammond SK. The effect of chronic exposure to PAHs on lung function in children. Presented at the Symposium on Cumulative Impacts and Children's Environmental Health, Sacramento, CA, January 16-17, 2013. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | Health impacts of air pollution in the San Joaquin Valley. | None | Balmes J | Balmes J. Health impacts of air pollution in the San Joaquin Valley. Presented via the American Lung Association of California Webinar, 2013. |
R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C002 (2012) R834596C003 (2012) |
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| Presentation | The Children's Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV): why we study asthma, birth outcomes, air pollution and immunology. | None | Hammond SK | Hammond SK. The Children's Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV): why we study asthma, birth outcomes, air pollution and immunology. Presented via a U.S. EPA Webinar, June 13, 2012. |
R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C002 (2012) R834596C003 (2012) |
not available |
| Presentation | The Children's Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV): asthma, birth outcomes, air pollution and immunology. | None | Hammond SK | Hammond SK. The Children's Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV): asthma, birth outcomes, air pollution and immunology. Presented at the University of California, Merced, Merced, CA, October 26, 2012. |
R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C002 (2012) R834596C003 (2012) |
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| Presentation | Immune function and ambient air pollution exposure in asthmatic children. | None | Humblet O, Noth EM, Lurmann FW, Pratt B, Hammond SK, Balmes J, Tager I, Nadeau K | Humblet O, Noth EM, Lurmann FW, Pratt B, Hammond SK, Balmes J, Tager I, Nadeau K. Immune function and ambient air pollution exposure in asthmatic children. Poster presented at the International Society for Environmental Epidemiology (ISEE) Annual Meeting, Barcelona, Spain, September 13-16, 2011. |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) |
not available |
| Presentation | Immune function and ambient air pollution exposure in asthmatic children. | None | Humblet O, Noth EM, Lurmann F, Pratt B, Hammond SK, Balmes J, Tager IB, Nadeau K | Humblet O, Noth EM, Lurmann F, Pratt B, Hammond SK, Balmes J, Tager IB, Nadeau K. Immune function and ambient air pollution exposure in asthmatic children. Poster presented at NIEHS and EPA Centers for Children's Environmental Health and Disease Prevention Research: Strengthening the Network, Bethesda, MD, March 6-7, 2012. |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | Lung function growth in asthmatic children in relation to prenatal/early-life second-hand smoke and GSTM1/GSTT1 polymorphisms. | None | Humblet O, Padula AM, Nadeau K, Holland N, Balmes I, Tager IB | Humblet O, Padula AM, Nadeau K, Holland N, Balmes I, Tager IB. Lung function growth in asthmatic children in relation to prenatal/early-life second-hand smoke and GSTM1/GSTT1 polymorphisms. Poster presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2012 (Poster No. A1759). |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Epigenetic changes in IFN-gamma and Foxp3 due to secondhand smoke. | None | Kohli A, Garcia M, Humblet O, Balmes J, Hammond K, Tager I, Nadeau K | Kohli A, Garcia M, Humblet O, Balmes J, Hammond K, Tager I, Nadeau K. Epigenetic changes in IFN-gamma and Foxp3 due to secondhand smoke. Presented at the Children's Environmental Health Network (CEHN) Research Conference, San Francisco, CA, May 30-June 1, 2012. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | PAH exposures and links to asthma outcomes. | None | Kohli A, Syed A, Hyman C, Li Z, Sjodin A, Eisen E, Noth E, Pratt B, Hammond K, Nadeau KC | Kohli A, Syed A, Hyman C, Li Z, Sjodin A, Eisen E, Noth E, Pratt B, Hammond K, Nadeau KC. PAH exposures and links to asthma outcomes. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) National Meeting, San Antonio, TX, February 22-26, 2013. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Polycyclic aromatic hydrocarbons methylate Foxp3 through the aryl hydrocarbon receptor in Treg. | None | Liu J, Cachola L, Nadeau KC | Liu J, Cachola L, Nadeau KC. Polycyclic aromatic hydrocarbons methylate Foxp3 through the aryl hydrocarbon receptor in Treg. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) National Conference, New Orleans, LA, March 18-22, 2011. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2010) R834596C003 (2011) R834596C003 (2012) |
not available |
| Presentation | Diesel exhaust particles induce conversion of CD4+CD25hiCD127lo regulatory T cells to CD4+CD25neg effector T cells. | None | Liu J, Nadeau KC | Liu J, Nadeau KC. Diesel exhaust particles induce conversion of CD4+CD25hiCD127lo regulatory T cells to CD4+CD25neg effector T cells. Presented at the American Thoracic Society International Conference, Denver, CO, May 13-18, 2011. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2010) R834596C003 (2011) R834596C003 (2012) R834786 (2011) |
not available |
| Presentation | Phenanthrene linked to AhR-mediated Treg instability and Th2 conversion. | None | Liu J, Winterroth L, Zhang L, Sunwoo J, Hammond SK, Balmes J, Tager IB, Nadeau K | Liu J, Winterroth L, Zhang L, Sunwoo J, Hammond SK, Balmes J, Tager IB, Nadeau K. Phenanthrene linked to AhR-mediated Treg instability and Th2 conversion. Poster presented at NIEHS and EPA Centers for Children's Environmental Health and Disease Prevention Research: Strengthening the Network, Bethesda, MD, March 6-7, 2012. |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | Daily changes in air pollution and lung function in the Fresno Asthmatic Children's Environment Study: use of individual-level exposure estimates for air pollutant concentrations. | None | Mann J, Pratt B, Lurmann F, Reid C, Tager I | Mann J, Pratt B, Lurmann F, Reid C, Tager I. Daily changes in air pollution and lung function in the Fresno Asthmatic Children's Environment Study: use of individual-level exposure estimates for air pollutant concentrations. Poster presented at the International Society for Environmental Epidemiology (ISEE) Annual Meeting, Barcelona, Spain, September 13-16, 2011. |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Daily changes in air pollution and lung function: use of modeled daily personal exposures. | None | Mann J, Lurmann F, Noth E, Balmes J, Hammond K, Alcorn S, Reid C, Pratt B, Tager IB | Mann J, Lurmann F, Noth E, Balmes J, Hammond K, Alcorn S, Reid C, Pratt B, Tager IB. Daily changes in air pollution and lung function: use of modeled daily personal exposures. Poster presented at NIEHS and EPA Centers for Children's Environmental Health and Disease Prevention Research: Strengthening the Network, Bethesda, MD, March 6-7, 2012. |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | Ambient air pollution effects on Treg in asthma. | None | McDonald C, Nadeau K | McDonald C, Nadeau K. Ambient air pollution effects on Treg in asthma. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) National Conference, New Orleans, LA, February 26-March 2, 2010. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2010) R834596C003 (2011) R834786 (2011) |
not available |
| Presentation | Ambient air pollution exposure associated with immune dysfunction. | None | Nadeau K | Nadeau K. Ambient air pollution exposure associated with immune dysfunction. Presented at the California Asthma Summit, San Francisco, CA, December 5-6, 2012. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
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| Presentation | The contribution of epigenetics in pediatric environmental health. | None | Nadeau K | Nadeau K. The contribution of epigenetics in pediatric environmental health. Presented at the California Asthma Summit, San Francisco, CA, December 5-6, 2012. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | New immune studies to understand the link between air pollution and asthma. | None | Nadeau K | Nadeau K. New immune studies to understand the link between air pollution and asthma. Presented via a U.S. EPA Webinar, June 13, 2012. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Mechanistic studies on the link between epigenetic modifications in candidate genes and allergy/asthma. | None | Nadeau K | Nadeau K. Mechanistic studies on the link between epigenetic modifications in candidate genes and allergy/asthma. Presented via a U.S. EPA Webinar, May 8, 2013. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Exposure to air pollution during pregnancy and pulmonary function growth in the FACES LiTE cohort. | None | Padula AM, Humblet O, Mortimer KM, Lurmann F, Tager IB | Padula AM, Humblet O, Mortimer KM, Lurmann F, Tager IB. Exposure to air pollution during pregnancy and pulmonary function growth in the FACES LiTE cohort. Poster presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2012 (Poster No. 31611). |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
| Presentation | Childhood exposure to polycyclic aromatic hydrocarbons is associated with impaired systemic immunity and epigenetic modifications in T cell subsets. | None | Walker A, Hew K, Kohli A, Syed A, Hyman C, Li Z, Sjodin A, Eisen E, Noth E, Pratt B, Balmes J, Hammond SK, Nadeau KC | Walker A, Hew K, Kohli A, Syed A, Hyman C, Li Z, Sjodin A, Eisen E, Noth E, Pratt B, Balmes J, Hammond SK, Nadeau KC. Childhood exposure to polycyclic aromatic hydrocarbons is associated with impaired systemic immunity and epigenetic modifications in T cell subsets. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) National Meeting, San Antonio, TX, February 22-26, 2013. |
R834596 (2012) R834596 (Final) R834596C003 (2012) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.