Grantee Research Project Results
Publications Details for Grant Number R826409
Mechanism(s) of Chloroethylene-Induced Autoimmunity
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Immunomodulation by trichloroethylene in the autoimmune prone MRL+/+ mice. | TOXICOLOGICAL SCIENCES | Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR | Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR. Immunomodulation by trichloroethylene in the autoimmune prone MRL+/+ mice. Toxicological Sciences 1998;42(1-S):7. |
R826409 (Final) |
not available |
Abstract | Cytochrome P450 2E1 metabolism of trichloroethylene accelerates an autoimmune response in MRL+/+ mice. | TOXICOLOGICAL SCIENCES | Griffin JM, Gilbert KM, Pumford NR | Griffin JM, Gilbert KM, Pumford NR. Cytochrome P450 2E1 metabolism of trichloroethylene accelerates an autoimmune response in MRL+/+ mice. Toxicological Sciences 1999;48(1-S):792. |
R826409 (Final) |
not available |
Abstract | Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment. | TOXICOLOGICAL SCIENCES | Pumford NR | Pumford NR. Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment. Toxicological Sciences 2001;60(S-1):206. |
R826409 (2000) R826409 (Final) |
not available |
Dissertation/Thesis | Acceleration of autoimmunity following exposure to trichloroethylene. | None | Griffin JM | Griffin JM. Acceleration of autoimmunity following exposure to trichloroethylene. Ph.D. Dissertation. University of Arkansas for Medical Sciences, DAI-B 60/12, June 2000, 6063 pp. |
R826409 (2000) R826409 (Final) |
not available |
Journal Article | Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response. | DRUG METABOLISM REVIEWS | Gilbert KM, Griffin JM, Pumford NR | Gilbert KM, Griffin JM, Pumford NR. Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response. Drug Metabolism Reviews 1999;31(4):901-916. |
R826409 (1999) R826409 (Final) |
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Journal Article | Covalent binding of trichloroethylene to proteins in human and rat hepatocytes. | TOXICOLOGY LETTERS | Griffin JM, Lipscomb JC, Pumford NR | Griffin JM, Lipscomb JC, Pumford NR. Covalent binding of trichloroethylene to proteins in human and rat hepatocytes. Toxicology Letters 1998;95(3):173-181. |
R826409 (Final) |
not available |
Journal Article | Inhibition of CYP2E1 reverses CD4+ T cell alterations in trichloroethylene-treated MRL+/+ mice. | TOXICOLOGICAL SCIENCES | Griffin JM, Gilbert KM, Pumford NR | Griffin JM, Gilbert KM, Pumford NR. Inhibition of CYP2E1 reverses CD4+ T cell alterations in trichloroethylene-treated MRL+/+ mice. Toxicological Sciences 2000;54(2):384-389. |
R826409 (1999) R826409 (Final) |
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Journal Article | Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL+/+ mice | IMMUNOPHARMACOLOGY | Griffin JM, Gilbert KM, Pumford NR | Griffin JM, Gilbert KM, Pumford NR. Cytochrome P450 2E1 metabolism of trichloroethylene accelerates an autoimmune response in MRL+/+ mice. Toxicological Sciences 1999;48(1-S):792 |
R826409 (Final) |
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Journal Article | CD4+ T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. | TOXICOLOGICAL SCIENCES | Griffin JM, Gilbert KM, Lamps LW, Pumford NR | Griffin JM, Gilbert KM, Lamps LW, Pumford NR. CD4+ T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. Toxicological Sciences, 2000;57(2):345-352. |
R826409 (2001) R826409 (Final) |
not available |
Journal Article | Trichloroethylene accelerates an autoimmune response in association with Th1 T-cell activation in MRL+/+ mice. | IMMUNOPHARMACOLOGY | Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR | Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR. Trichloroethylene accelerates an autoimmune response in association with Th1 T-cell activation in MRL+/+ mice. Immunopharmacology, 2000;46(2):123-137. |
R826409 (1999) R826409 (Final) |
not available |
Presentation | Environmental contaminant associated with induction of autoimmune disease stimulates T-cells. | None | Gilbert KM, Whitlow AB, Pumford NR | Gilbert KM, Whitlow AB, Pumford NR. Environmental contaminant associated with induction of autoimmune disease stimulates T-cells. Presented at the Experimental Biology Meeting, New Orleans, LA, April 20, 2002. |
R826409 (2001) R826409 (Final) |
not available |
Presentation | Cytochrome P450 activation of trichloroethylene initiates a Th1 T-cell response in MRL+/+ mice. | None | Griffin JM, Gilbert KM, Pumford NR | Griffin JM, Gilbert KM, Pumford NR. Cytochrome P450 activation of trichloroethylene initiates a Th1 T-cell response in MRL+/+ mice. Presented at the Workshop on Linking Environmental Agents and Autoimmune Diseases, National Institutes of Health, National Institute of Environmental Health Sciences, September 1-3, 1998. |
R826409 (Final) |
not available |
Presentation | Chemical-induced immune-mediated hepatotoxicity. | None | Pumford NR | Pumford NR. Chemical-induced immune-mediated hepatotoxicity. Presented at the Workshop on Linking Environmental Agents and Autoimmune Diseases, National Institutes of Health, National Institute of Environmental Health Sciences, September 1-3, 1998. |
R826409 (Final) |
not available |
Presentation | Chlorinated ethylenes and autoimmune disease. | None | Pumford NR | Pumford NR. Chlorinated ethylenes and autoimmune disease. Presented at the Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, 2001. |
R826409 (Final) |
not available |
Presentation | Immunochemical approaches used to identify and characterize protein adducts associated with xenobiotic-induced toxicities. | None | Pumford NR | Pumford NR. Immunochemical approaches used to identify and characterize protein adducts associated with xenobiotic-induced toxicities. Presented at the International Society for the Study of Xenobiotics (ISSX) Annual North American Meeting, 1999. |
R826409 (Final) |
not available |
Presentation | Mechanism(s) of chloroethylene-induced autoimmunity. | None | Pumford NR | Pumford NR. Mechanism(s) of chloroethylene-induced autoimmunity. Presented at the U.S. Environmental Protection Agency Science Forum 2002: Meeting the Challenges, Washington, DC, May 1-2, 2002. |
R826409 (2001) R826409 (Final) |
not available |
Presentation | Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment. | None | Pumford NR | Pumford NR. Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826409 (2000) |
not available |
Presentation | Trichloroethylene and autoimmunity. | None | Pumford NR | Pumford NR. Trichloroethylene and autoimmunity. Presented at the Drinking Water and Health Symposium, University of Florida Center for Environmental and Human Health, Superfund Basic Research Program Project, 1999. |
R826409 (Final) |
not available |
Proceedings | Immunochemical approaches used to identify and characterize protein adducts associated with xenobiotic-induced toxicities | None | Pumford NR | Pumford NR. Immunochemical approaches used to identify and characterize protein adducts associated with xenobiotic-induced toxicities. In: Proceedings of the invited symposium presentation at the ISSX Annual North American Meeting, Volume 15, October 27, 1999. |
R826409 (1999) R826409 (Final) |
not available |
Proceedings | Mechanism(s) of chloroethylene-induced autoimmunity. | None | Pumford NR | Pumford NR. Mechanism(s) of chloroethylene-induced autoimmunity. In: Proceedings of the Environmental Protection Agency Science Forum 2002: Meeting the Challenges, May 1-2, 2002, p. 96. |
R826409 (Final) |
not available |
Proceedings | Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment | None | Pumford NR | Pumford NR. Oxidative stress and endothelial cell damage in autoimmune-prone MRL+/+ mice following trichloroethylene treatment. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2001. |
R826409 (1999) R826409 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.