Grantee Research Project Results
Publications Details for Grant Number R829388C006
Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism
RFA:
Centers for Children's Environmental Health and Disease Prevention Research (2001)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. | MUSCLE & NERVE | Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN | Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN. Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. Muscle & Nerve 2004;30(3):356-365. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. | JOURNAL OF BIOLOGICAL CHEMISTRY | Chen L, Esteve E, Sabatier J-M, Ronjat M, De Waard M, Allen PD, Pessah IN | Chen L, Esteve E, Sabatier J-M, Ronjat M, De Waard M, Allen PD, Pessah IN. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. Journal of Biological Chemistry 2003;278(18):16095-16106. |
R829388 (2006) R829388 (Final) R829388C006 (2003) R829388C006 (2005) |
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Journal Article | NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. | CIRCULATION RESEARCH | Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN | Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circulation Research 2004;94(4):478-486. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA | Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN | Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15793-15798. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. | ENVIRONMENTAL HEALTH PERSPECTIVES | Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF | Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. |
R827027 (2002) R829388 (2006) R829388 (Final) R829388C006 (2005) R829389 (2005) R829389 (Final) R829390 (2005) R829390 (Final) R829390C002 (2005) R831710 (2005) R831710 (Final) R831711 (2005) R832141 (2006) R832141 (2007) R832141 (Final) |
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Journal Article | Homer regulates gain of ryanodine receptor type 1 channel complex. | JOURNAL OF BIOLOGICAL CHEMISTRY | Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN | Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN. Homer regulates gain of ryanodine receptor type 1 channel complex. Journal of Biological Chemistry 2002;277(47):44722-44730. |
R829388 (2006) R829388 (Final) R829388C006 (2003) R829388C006 (2005) |
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Journal Article | Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. | TOXICOLOGICAL SCIENCES | Gafni J, Wong PW, Pessah IN | Gafni J, Wong PW, Pessah IN. Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicological Sciences 2004;77(1):72-82. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. | TOXICOLOGY SCIENCE | Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW | Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicological Sciences 2005;87(2):419-426. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. | JOURNAL OF IMMUNOLOGICAL METHODS | Goth SR, Chu RA, Pessah IN | Goth SR, Chu RA, Pessah IN. Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. Journal of Immunological Methods 2006;308(1-2):179-191. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R833292 (2007) R833292 (2009) R833292 (Final) |
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Journal Article | Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. | ENVIRONMENTAL HEALTH PERSPECTIVES | Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN | Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environmental Health Perspectives 2006;114(7):1083-1091. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R833292 (2007) R833292 (Final) |
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Journal Article | Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. | TOXICOLOGY | Hansen ME, Pessah IN, Matsumura F | Hansen ME, Pessah IN, Matsumura F. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology 2006;220(2-3):218-231. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Howard AS, Fitzpatrick R, Pessah IN, Kostyniak P, Lein PJ | Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology 2003;190(1):72-86. |
R829388 (2006) R829388 (Final) R829388C006 (2003) R829388C006 (2005) |
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Journal Article | Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. | JOURNAL OF BIOLOGICAL CHEMISTRY | Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN | Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. Journal of Biological Chemistry 2005;280(44):36994-37004. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. | None | Kim KH, Inan SY, Berman RF, Pessah IN | Kim KH, Inan SY, Berman RF, Pessah IN. Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicology and Applied Pharmacology 2009;237(2):168-177. |
R829388 (Final) R829388C006 (2005) R833292 (Final) |
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Journal Article | Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. | TOXICOLOGY SCIENCE | Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL | Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicological Sciences 2005;88(2):400-411. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R829390 (2005) R829390 (Final) |
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Journal Article | Evidence for conformational coupling between two calcium channels. | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES | Paolini C, Fessenden JD, Pessah IN, Franzini-Armstrong C | Paolini C, Fessenden JD, Pessah IN, Franzini-Armstrong C. Evidence for conformational coupling between two calcium channels. Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12748-12752. |
R829388 (Final) R829388C006 (2005) |
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Journal Article | Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). | CHEMICAL RESEARCH IN TOXICOLOGY | Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, Wong PW | Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, Wong PW. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chemical Research in Toxicology 2006;19(1):92-101. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R833292 (2007) R833292 (2009) R833292 (Final) |
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Journal Article | Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. | NEUROTOXICOLOGY AND TERATOLOGY | Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL | Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R829390 (2005) R829390 (Final) R829390C001 (2005) |
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Journal Article | Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitive Ca2+-induced Ca2+ release mediated by ryanodine receptors. | MOLECULAR PHARMACOLOGY | Ta TA, Feng W, Molinski TF, Pessah IN | Ta TA, Feng W, Molinski TF, Pessah IN. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitive Ca2+-induced Ca2+ release mediated by ryanodine receptors. Molecular Pharmacology 2006;69(2):532-538. |
R829388 (2006) R829388 (Final) R829388C006 (2005) R833292 (Final) |
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Journal Article | Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. | JOURNAL OF BIOLOGICAL CHEMISTRY | Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN | Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. Journal of Biological Chemistry 2004;279(33):34514-34520. |
R829388 (2006) R829388 (Final) R829388C006 (2005) |
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Journal Article | Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle | None | Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF | Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. Journal of Biological Chemistry 2004;279(7):5781-5787. |
R829388 (Final) R829388C006 (2005) |
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Presentation | Acute nanomolar thimerosal induces DNA damage in cultured dendritic cells. | None | Goth, S.R., Chu, R., van De Water, J., Pessah, I.N. | Goth, S.R., Chu, R., van De Water, J., and Pessah, I.N. Acute nanomolar thimerosal induces DNA damage in cultured dendritic cells. |
R829388C002 (2003) R829388C006 (2003) |
not available |
Presentation | Characterization of RyR1-expressing and -null dendritic cells isolated from fetal liver. | None | Goth, S.R. Chu, R., van De Water, J. Pessah I.N. | Goth, S.R. Chu, R., van De Water, J. and Pessah I.N. Characterization of RyR1-expressing and -null dendritic cells isolated from fetal liver. |
R829388C002 (2003) R829388C006 (2003) |
not available |
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