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Abstract (3)
Book Chapter (1)
Journal Article (43)
Presentation (58)
Proceedings (10)
Reference Type Citation Progress Report Year Document Sources
Abstract Easterling M, Tropsha A, Ye L, Pirone J, Zhu H, Martin T, Moudgal C. Quantitative structure toxicity relationships (QSTR) models for predicting acute/sub-acute and sub-chronic/chronic adverse effect levels. The Toxicologist 2009;108(1):234. R832720 (2009)
Abstract Zhang L, Zhu H, Rusyn I, Judson R, Dix D, Houck K, Martin M, Richard A, Kavlock R, Tropsha A. Cheminformatics analysis of EPA ToxCast chemical libraries to identify domains of applicability for predictive toxicity models and prioritize compounds for toxicity testing. The Toxicologist 2009;108(1):226. R832720 (2009)
Abstract Zhu H, Martin TM, Ye L, Young DM, Tropsha A. Combinatorial QSAR modeling of rat acute toxicity by oral exposure. The Toxicologist 2009;108(1):234. R832720 (2009)
Book Chapter Stotts D, Lee K, Rusyn I. Supporting computational systems science: genomic analysis tool federations using aspects and AOP. In: Mandoiu I, Sunderraman R, Zelikovsky A, eds. Bioinformatics Research and Applications. Proceedings of the Fourth International Symposium ISBRA 2008. Berlin/Heidelberg, Germany: Springer Berlin/Heidelberg, 2008, pp. 457-468. R832720 (2008)
Journal Article Borysov P, Hannig J, Marron JS, Muratov E, Fourches D, Tropsha A. Activity prediction and identification of mis-annotated chemical compounds using extreme descriptors. Journal of Chemometrics 2016;30(3):99-108. R832720 (2009)
R833825 (Final)
Journal Article Bradford BU, O'Connell TM, Han J, Kosyk O, Shymonyak S, Ross PK, Winnike J, Kono H, Rusyn I. Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicology and Applied Pharmacology 2008;232(2):236-243. R832720 (2008)
Journal Article Chen M-H, Ibrahim JG, Chi Y-Y. A new class of mixture models for differential gene expression in DNA microarray data. Journal of Statistical Planning and Inference 2008;138(2):387-404. R832720 (2006)
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Journal Article Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical Research in Toxicology 2010;23(1):171-183. R832720 (2009)
R833825 (Final)
Journal Article Fourches D, Muratov E, Tropsha A. Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research. Journal of Chemical Information and Modeling 2010;50(7):1189-1204. R832720 (2009)
R833825 (Final)
Journal Article Fourches D, Muratov E, Ding F, Dokholyan NV, Tropsha A. Predicting binding affinity of CSAR ligands using both structure-based and ligand-based approaches. Journal of Chemical Information and Modeling 2013;53(8):1915-1922. R832720 (2009)
R833825 (Final)
Journal Article Gatti DM, Shabalin AA, Lam T-C, Wright FA, Rusyn I, Nobel AB. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics 2009;25(4):482-489. R832720 (2008)
R833825 (2008)
R833825 (Final)
Journal Article Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics 2009;25(4):541-542. R832720 (2008)
R833825 (Final)
Journal Article Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mammalian Genome 2009;20(7):437-446. R832720 (2009)
R833825 (Final)
Journal Article Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology 2007;46(2):548-557. R832720 (2007)
R832720 (2008)
Journal Article Gelfond JAL, Ibrahim JG, Zou F. Proximity model for expression quantitative trait loci (eQTL) detection. Biometrics 2007;63(4):1108-1116. R832720 (2006)
R832720 (2008)
Journal Article Ghosh A, Zou F, Wright FA. Estimating odds ratios in genome scans: an approximate conditional likelihood approach. The American Journal of Human Genetics 2008;82(5):1064-1074. R832720 (2008)
Journal Article Graham MR, Virtaneva K, Porcella SF, Gardner DJ, Long RD, Welty DM, Barry WT, Johnson CA, Parkins LD, Wright FA, Musser JM. Analysis of the transcriptome of Group A Streptococcus in mouse soft tissue infection. American Journal of Pathology 2006;169(3):927-942. R832720 (2007)
R832720 (2008)
Journal Article Gupta M, Ibrahim JG. Variable selection in regression mixture modeling for the discovery of gene regulatory networks. Journal of the American Statistical Association 2007;102(479):867-880. R832720 (2006)
R832720 (2008)
Journal Article Gupta M. Generalized hierarchical Markov models for the discovery of length-constrained sequence features from genome tiling arrays. Biometrics 2007;63(3):797-805. R832720 (2006)
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Journal Article Han J, Danell RM, Patel JR, Gumerov DR, Scarlett CO, Speir JP, Parker CE, Rusyn I, Zeisel S, Borchers CH. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics 2008;4(2):128-140. R832720 (2008)
Journal Article Harrill AH, Rusyn I. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opinion on Drug Metabolism & Toxicology 2008;4(11):1379-1389. R832720 (2008)
Journal Article Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicological Sciences 2009;110(1):235-243. R832720 (2009)
R833825 (2008)
R833825 (Final)
Journal Article Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Research 2009;19(9):1507-1515. R832720 (2009)
Journal Article Harrill JA ,Li Z, Wright FA, Radio NM, Mundy WR, Tornero-Velez R, Crofton KM. Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. BMC Genomics 2008;9:546. R832720 (2008)
Journal Article Hu J, Wright FA, Zou F. Estimation of expression indexes for oligonucleotide arrays using the singular value decomposition. Journal of the American Statistical Association 2006;101(473):41-50. R832720 (2006)
R832720 (2008)
Journal Article Hu J, Wright FA. Assessing differential gene expression with small sample sizes in oligonucleotide arrays using a mean-variance model. Biometrics 2007;63(1):41-49. R832720 (2006)
R832720 (2008)
Journal Article Judson R, Elloumi F, Setzer RW, Li Z , Shah I. A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model. BMC Bioinformatics 2008;9:241-256. R832720 (2008)
Journal Article Li Z, Wright FA, Royland J. Age-dependent variability in gene expression in male Fischer 344 rat retina. Toxicological Sciences 2009;107(1):281-292. R832720 (2008)
Journal Article Liu Y, Hayes D, Nobel A, Marron J. Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION 2012;103(483):1281-1293. R832720 (2009)
Journal Article Low YS, Sedykh AY, Rusyn I, Tropsha A. Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Current Topics in Medicinal Chemistry 2014;14(11):1356-1364. R832720 (2009)
R833825 (Final)
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R835166 (2014)
R835166 (2016)
R835166 (Final)
Journal Article Muratov EN, Varlamova EV, Artemenko AG, Khristova T, Kuz'min VE, Makarov VA, Riabova OB, Wutzler P, Schmidtke M. QSAR analysis of [(biphenyloxy)propyl] isoxazoles: agents against coxsackievirus B3. Future Medicinal Chemistry 2011;3(1):15-27. R832720 (2009)
R833825 (Final)
Journal Article Muratov EN, Varlamova EV, Artemenko AG, Polishchuk PG, Kuz'min VE. Existing and developing approaches for QSAR analysis of mixtures. Molecular Informatics 2012;31(3-4):202-221. R832720 (2009)
R833825 (Final)
Journal Article Muratov EN, Varlamova EV, Artemenko AG, Polishchuk PG, Nikolaeva-Glomb L, Galabov AS, Kuz'min VE. QSAR analysis of poliovirus inhibition by dual combinations of antivirals. Structural Chemistry 2013;24(5):1665-1679. R832720 (2009)
R833825 (Final)
Journal Article Nadler JJ, Zou F, Huang H, Moy SS, Lauder J, Crawley JN, Threadgill DW, Wright FA, Magnuson TR. Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics 2006;174(3):1229-1236. R832720 (2006)
R832720 (2008)
Journal Article Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. Journal of Hepatology 2009;51(1):176-186. R832720 (2009)
Journal Article Polishchuk PG, Kuz'min VE, Artemenko AG, Muratov EN. Universal approach for structural interpretation of QSAR/QSPR models. Molecular Informatics 2013;32(9-10):843-853. R832720 (2009)
Journal Article Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill DW. The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mammalian Genome 2007;18(6-7):473-481. R832720 (2007)
R832720 (2008)
Journal Article Scharph R, Tjelmeland H, Parmigiani G, Nobel A. A Bayesian Model for Cross-Study Differential Gene Expression. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION 2012;104(488):1295-1310 R832720 (2009)
Journal Article Tetko IV, Sushko I, Pandey AK, Zhu H, Tropsha A, Papa E, Oberg T, Todeschini R, Fourches D, Varnek A. Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: focusing on applicability domain and overfitting by variable selection. Journal of Chemical Information and Modeling 2008;48(9):1733-1746. R832720 (2008)
Journal Article Tropsha A, Golbraikh A. Predictive QSAR modeling workflow, model applicability domains, and virtual screening. Current Pharmaceutical Design 2007;13(34):3494-3504. R832720 (2007)
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Journal Article Woods CG, Kosyk O, Bradford BU, Ross PK, Burns AM, Cunningham ML, Qu P, Ibrahim JG, Rusyn I. Time course investigation of PPARα- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression. Toxicology and Applied Pharmacology 2007;225(3):267-277. R832720 (2007)
R832720 (2008)
Journal Article Woods CG, Vanden Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicologic Pathology 2007;35(4):474-494. R832720 (2007)
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Journal Article Wright FA, Huang H, Guan X, Gamiel K, Jeffries C, Barry WT, Pardo-Manuel de Villena F, Sullivan PF, Wilhelmsen KC, Zou F. Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. Bioinformatics 2007;23(19):2581-2588. R832720 (2007)
R832720 (2008)
Journal Article Zhu H, Tropsha A, Fourches D, Varnek A, Papa E, Gramatica P, Oberg T, Dao P, Cherkasov A, Tetko IV. Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. Journal of Chemical Information and Modeling 2008;48(4):766-784. R832720 (2008)
Journal Article Zhu H, Rusyn I, Richard A, Tropsha A. Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environmental Health Perspectives 2008;116(4):506-513. R832720 (2007)
R832720 (2008)
R833825 (2008)
R833825 (Final)
Journal Article Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environmental Health Perspectives 2009;117(8):1257-1264. R832720 (2009)
R833825 (2008)
R833825 (Final)
Journal Article Zhu H, Martin TM, Ye L, Sedykh A, Young DM, Tropsha A. Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure. Chemical Research in Toxicology 2009;22(12):1913-1921. R832720 (2009)
R833825 (Final)
Presentation Bradford BU, Han J, Kosyk O, Shymonyak S, Winnike J, Kono H, O’Connell T, Rusyn I. Metabolomic analysis of urine and liver after chronic alcohol treatment in C57BL/6J mice. Presented at the 58th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, November 2-6, 2007. R832720 (2007)
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Presentation Bradford BU, Kim S, Kosyk O, Grimes J, O’Connell T, Rusyn I. NMR and microarray based analysis of mouse liver following exposure to trichloroethylene. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-10, 2010. R832720 (2009)
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Presentation Campbell J, Clewell H, Kim S, Collins L, Kosyk O, Rusyn I. Monte Carlo analysis of TCE metabolism across a panel of inbred mouse strains. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-10, 2010. R832720 (2009)
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Presentation Chang Y-L, Zou F, Wright FA. Approximate Bayesian approaches for quantitative trait loci estimation. Presented at the International Biometric Society's Eastern North American Region (ENAR) Spring Meeting, Atlanta, GA, March 11-14, 2007 (contributed presentation). R832720 (2007)
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Presentation Chang Y-L, Zou F, Wright FA. Approximate Bayesian approaches for quantitative trait loci estimation. Presented at the Biostatistics Colloquium, Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 2007. R832720 (2007)
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Presentation DeSimone MC, Harbourt D, Boysen G, Collins L, et al. Multi-strain study of trichoroethylene toxicity in mice. Presented at the Superfund Basic Research Program Annual Meeting: New Technologies to Assess Environmental Exposure, San Diego, CA, December 10-12, 2006. R832720 (2006)
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Presentation Dix D, Martin MT, Li Z, Judson R, Houck KA. Development of EPA’s ToxCast program for prioritizing the toxicity testing of environmental chemicals. Presented at the Society for Biomolecular Sciences 13th Annual Conference and Exhibition, Montreal, Canada, April 15-19, 2007. R832720 (2007)
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Presentation Dix D, Judson R, Kavlock R, Li Z, Martin M, Richard A, Setzer W, Houck K. EPA’s ToxCast program for predicting hazard and prioritizing toxicity testing of environmental chemicals. Presented at the 2007 International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21-23, 2007. R832720 (2007)
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Presentation Easterling M, Tropsha A, Ye L, Pirone J, Zhu H, Martin T, Moudgal C. Quantitative structure toxicity relationships (QSTR) models for predicting acute/sub-acute and sub-chronic/chronic adverse effect levels. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2009)
R833825 (2008)
R833825 (Final)
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Presentation Elloumi F, Li Z, Judson R. EPA Analysis for MAQC toxicogenomics datasets. Presented at the 8th MAQC Project Meeting: Development and Validation of Predictive Models, Washington, DC, March 24-26, 2008. R832720 (2008)
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Presentation Elloumi F, Judson R, Dix D, Shah I, Knudsen T, Reif D, Singh A, Li Z, Wright FA. Response profiles from toxicogenomics data. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2009)
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Presentation Gatti DM, Shabalin AA, Rusyn I, Wright FA, Nobel AB. Fast association mapping using summation trees. Presented at the 7th Annual Meeting of the Complex Trait Consortium, Montreal, Canada, May 31-June 3, 2008. R832720 (2008)
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Presentation Gatti D, Maki A, Chesler EJ, Kirova R, et al. Examination of genetic networks that regulate gene expression in liver using complex trait analysis. Presented at the 46th Society of Toxicology Annual Meeting, Charlotte, NC, March 25-29, 2007. R832720 (2006)
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Presentation Golbraikh A, Zhu H, Ye L, Wang-Bell M, Tang H, Tropsha A. QSAR/QSTR analysis of imbalanced datasets using k-Nearest Neighbors approach. Presented at the Fourth International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources, Moscow, Russia, September 11-15, 2007. R832720 (2007)
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Presentation Golbraikh A, Zhu H, Ye L, Wang-Bell M, Tang H, Tropsha A. Automatic detection of outliers prior to QSAR studies. Presented at the 235th American Chemical Society National Meeting, New Orleans, LA, April 6-10, 2008. R832720 (2008)
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Presentation Grimes J, Kim S, O'Connell T, Bradford B, Rusyn I. Analysis of trichloroethylene metabolism in a genetically diverse panel of inbred mouse strains. Presented at the 5th International Metabolomics Society Conference, Edmonton, Alberta, Canada, August 30-September 2, 2009. R832720 (2009)
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Presentation Han J, Harbourt D, Danell RM, Borchers CH, et al. High-throughput metabolite profiling of serum from trichloroethylene-exposed mice by direct infusion FTICR-MS. Presented at the Superfund Basic Research Program Annual Meeting: New Technologies to Assess Environmental Exposure, San Diego, CA, December 10-12, 2006. R832720 (2006)
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Presentation Hatcher S, Kosyk O, Ross P, Wright FA, Schwartz J, Dix D, Rusyn I. In vitro screening for chemical toxicity in a genetically-diverse human model system. Poster presented at the EPA ToxCast Data Analysis Summit, Research Triangle Park, NC, May 14-15, 2009. R832720 (2009)
Presentation Hege A, Ross P, Su S, Stylianou I, et al. Toxicogenetic dimension in studies of the mechanisms of liver injury. Presented at the U.S. Environmental Protection Agency Science Forum, Washington, DC, May 16-18, 2006. R832720 (2006)
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Presentation Hege A, Ross P, Balletta L, Bradford B, et al. Cross-species association mapping identifies genetic risk factors for liver toxicity. Presented at the 46th Society of Toxicology Annual Meeting, Charlotte, NC, March 25-29, 2007. R832720 (2006)
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Presentation Hege A, Ross PK, Threadgill DW, Rusyn I. Phenotypic anchoring of gene expression data from acetaminophen hepatotoxicity studies in the mouse model of the human population reveals biomarkers of response. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2007)
R832720 (2008)
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Presentation Kavlock RJ, Dix D, Judson R, Li Z, Martin M, Richard A, Setzer W, Houck K. U.S. EPA’s ToxCast program for predicting hazard and prioritizing toxicity testing of environmental chemicals. Presented at the 6th World Congress on Alternatives and Animal Use in the Life Sciences, Tokyo, Japan, August 21-25, 2007. R832720 (2007)
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Presentation Kim S-K, DeSimone MC, Harbourt D, Boysen G, Collins L, Waidyanatha S, Bradford BU, Threadgill DW, Rusyn I. Analysis of trichloroethylene metabolism in a genetically diverse panel of mouse inbred strains. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2007)
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Presentation Lee K, Stotts D. Using aspects to create interconnected analysis tool networks. Presented at the International Symposium on Bioinformatics Research and Applications, Athens, GA, May 6-8, 2008. R832720 (2007)
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Presentation Lee MH, Rusyn I, Threadgill DW, Marron JS. Visualization of features in curve estimates and application to genetic loci mapping. Presented at the Joint Statistical Meeting of the American Statistical Association, Seattle, WA, August 6-10, 2006. R832720 (2006)
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Presentation Li Z, Wright FA, Royland JE. Age-dependent heterogeneity of gene expression in Fisher 344 rat retina. Presented at the Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 25-29, 2007. R832720 (2007)
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Presentation Li Z, Wright FA. Discovering relevant pathways in microarray experiments-a tutorial on honest testing methods. Presented at the U.S. Environmental Protection Agency's Info on Informatics Series, Research Triangle Park, NC, 2007. R832720 (2007)
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Presentation Li Z, Wright FA, Royland JE. Significance analysis of variation change in gene expression studies. Presented at the 15th Annual International Conference on Intelligent Systems for Molecular Biology and 6th Annual European Conference on Computational Biology, Vienna, Austria, July 21-15, 2007. R832720 (2007)
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Presentation Li Z, Wright FA, Elloumi F. Chemical toxicity prediction for ToxCast Phase I. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2007)
R832720 (2008)
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Presentation Li Z, Rusyn I, Wright FA. Dose-response pathway analysis for gene expression microarrays. Presented at the Symposium on Toxicity Pathway-Based Risk Assessment: Preparing for Paradigm Change, The National Academy of Sciences, Washington, DC, May 11-13, 2009. R832720 (2009)
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Presentation Li Z, Rusyn I, Wright FA. Dose-response pathway analysis for gene expression microarrays. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-10, 2010. R832720 (2009)
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Presentation Liu J, Chang Y-L, Zou F, Wright FA. A fast Bayesian method for eQTL linkage analysis in experimental crosses. Presented at the 2007 Joint Statistical Meetings, Salt Lake City, UT, July 29-August 2, 2007. R832720 (2007)
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Presentation Martinez S, Bradford B, Kaiser R, Soldatow V, Amaral K, Ferguson S, Black C, LecLuyse E, Rusyn I. Development of the in vitro toxicogenetic models for hepatotoxicity. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2008)
R833825 (2008)
R833825 (Final)
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Presentation Martinez S, Bradford B, Kaiser R, Soldatow V, Amaral K, Ferguson S, Black C, LecLuyse E, Rusyn I. Development of in vitro toxicogenetic models for hepatotoxicity. Presented at the EPA ToxCast Data Analysis Summit, Research Triangle Park, NC, May 14-15, 2009. R832720 (2009)
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Presentation O’Shea SH, Schwarz J, Kosyk O, Ross PK, Wright FA, Tice RR, Dix DJ, Rusyn I. In vitro screening for population variability in chemical toxicity. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-10, 2010. R832720 (2009)
R833825 (Final)
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Presentation Rodgers AD, Zhu H, Rusyn I, Tropsha A. QSAR modeling of human liver adverse effects database using kNN method. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2008)
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Presentation Ross PL, Woods, CG, Bradford BU, Kosyk O, Rusyn I. Time-course comparison of gene expression signatures of xenobiotic activators of car and PPAR-alpha in mouse liver. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2008)
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Presentation Rusyn I. Genetical genomics and liver toxicology. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2008)
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Presentation Rusyn I. Use of inbred mouse strains to model genetic variation in susceptibility to drug-induced liver injury. Presented at the Hepatotoxicity Summit, Philadelphia, PA, 2008. R832720 (2008)
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Presentation Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. Using in vitro dose-response profiles to enhance QSAR modeling of in vivo toxicity. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-10, 2010. R832720 (2009)
R833825 (Final)
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Presentation Tropsha A. Combinational QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. Presented at the Fourth International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources, Moscow, Russia, September 11-15, 2007. R832720 (2007)
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Presentation Tropsha A, Golbraikh A, Zhu H. Applicability domains, space coverage, and predictive power of QSAR models. Presented at the 235th American Chemical Society National Meeting, New Orleans, LA, April 6-10, 2008. R832720 (2008)
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Presentation Wang K, Richard A, Rusyn I, Tropsha A. Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database. Presented at the 46th Society of Toxicity Annual Meeting, Charlotte, NC, March 25-29, 2007. R832720 (2006)
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Presentation Winnike JH, Li Z, Wright FA, Macdonald JM, O’Connell TM, Watkins PB. Pharmaco-metabolomics and the prediction of hepatotoxicity. Presented to the Research Triangle Park Drug Metabolism Discussion Group, Research Triangle Park, NC, 2007. R832720 (2007)
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Presentation Wright FA, Nobel AB, Barry WT. Hypothesis tests of functional categories in microarray data–a new approach. Presented at the UIUC Bioinformatics Seminar Series, Urbana-Champaign, IL, 2007. R832720 (2007)
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Presentation Wright FA, Li Z, Huang HW, Ghosh A, Sun W, Zou F, Rusyn I. Prediction of in vivo toxicity endpoints from ToxCast Phase I data using a variety of machine learning approaches. Presented at the EPA ToxCast Data Analysis Summit, Research Triangle Park, NC, May 14-15, 2009. R832720 (2009)
Presentation Ye L, Zhu H, Golbraikh A, Tropsha A. Enhanced kNN-QSAR modeling of aquatic toxicity of diverse organic compounds tested by fathead minnow. Presented at the Microsoft eScience Workshop, Chapel Hill, NC, October 21, 2007. R832720 (2007)
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Presentation Ye L, Zhu H, Golbraikh A, Tropsha A. Establishing a balance between prediction accuracy and applicability domain of QSAR models. Presented at the 235th American Chemical Society National Meeting, New Orleans, LA, April 6-10, 2008. R832720 (2008)
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Presentation Zhang L, Zhu H, Rusyn I, Judson R, Dix D, Houck K, Martin M, Richard A, Kavlock R, Tropsha A. Cheminformatics analysis of EPA ToxCast chemical libraries to identify domains of applicability for predictive toxicity models and prioritize compounds for toxicity testing. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2008)
R832720 (2009)
R833825 (2008)
R833825 (Final)
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Presentation Zhang L, Zhu H, Rusyn I, Judson R, Dix D, Houck K, Martin M, Richard A, Kavlock R, Tropsha A. Cheminformatics analysis of EPA ToxCast chemical libraries to develop predictive toxicity models and prioritize compounds for in vivo toxicity testing. Presented at the EPA ToxCast Data Analysis Summit, Research Triangle Park, NC, May 14-15, 2009. R832720 (2009)
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Presentation Zhao N, Gatti DM, Rusyn I. Genome-level analysis of genetic regulation of sex-specific gene expression in mouse liver. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2008)
R833825 (2008)
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Presentation Zhu H, Wang K, Rusyn I, Richard A, Tropsha A. The utilization of NTP-HTS data in predictive ADME/tox modeling. Presented at the 46th Society of Toxicity Annual Meeting, Charlotte, NC, March 25-29, 2007. R832720 (2006)
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Presentation Zhu H, Tropsha A, Fourches D, Varnek A, Papa E, Gramatica P, Oberg T, Dao P, Cherkasov A, Tetko IV. Combinational QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. Presented at the 2007 International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21-23, 2007. R832720 (2007)
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Presentation Zhu H, Tropsha A, Fourches D, Varnek A, Papa E, Gramatica P, Oberg T, Dao P, Cherkasov A, Tetko IV. Combinational QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. Presented at the Microsoft eScience Workshop, Chapel Hill, NC, October 21, 2007. R832720 (2007)
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Presentation Zhu H, Rusyn I, Richard A, Tropsha A. The utilization of NTP-HTS data in predictive ADME/tox modeling. Presented at the 2007 International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21-23, 2007. R832720 (2007)
 not available
Presentation Zhu H, Ye L, Rusyn I, Richard A, Golbraikh A, Tropsha A. Two-step quantitative structure activity relationship modeling of in vivo toxicity using in vitro cytotoxicity data. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008. R832720 (2008)
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Presentation Zhu H, Martin TM, Ye L, Young DM, Tropsha A. Combinatorial QSAR modeling of rat acute toxicity by oral exposure. Presented at the Society of Toxicology 48th Annual Meeting and ToxExpo, Baltimore, MD, March 15-19, 2009. R832720 (2009)
R833825 (2008)
R833825 (Final)
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Presentation Zhu H, Sedykh A, Zhang L, Rusyn I, Tropsha A. Using ToxCast cell-viability and gene-expression assays as biological descriptors in QSAR modeling of animal toxicity endpoints. Poster presented at the EPA ToxCast Data Analysis Summit, Research Triangle Park, NC, May 14-15, 2009. R832720 (2009)
R833825 (2008)
R833825 (Final)
 not available
Proceedings Liu J, Paulsen S, Sun X, Wang W, Nobel A, Prins J. Mining approximate frequent itemset in the presence of noise: algorithm and analysis. In: Proceedings of the Sixth Society for Industrial and Applied Mathematics Conference on Data Mining, Bethesda, MD, April 20-22, 2006, pp. 405-416. R832720 (2006)
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Proceedings Liu J, Zhang Q, Wang W, McMillan L, Prins J. Clustering pair-wise dissimilarity data into partially ordered sets. In: Proceedings of the 12th Association for Computer Machinery Special Interest Group on Knowledge Discovery and Data Mining, International Conference on Knowledge Discovery and Data Mining, Philadelphia, PA, August 20-23, 2006, pp. 637-642. R832720 (2006)
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Proceedings Liu J, Zhang Q, Wang W, McMillan L, Prins J. PoClustering: lossless clustering of dissimilarity data. In: Proceedings of the 2007 SIAM International Conference on Data Mining, Radisson University Hotel, Minneapolis, MN, April 26-28, 2007. R832720 (2007)
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Proceedings Pan F, Roberts A, McMillan L, Pardo-Manuel de Villena F, Threadgill D, Wang W. Sample selection for maximal diversity. In: Proceedings of the IEEE International Conference on Data Mining, Ohama, NE, October 28-31, 2007, pp. 262-271. R832720 (2007)
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Proceedings Roberts A, McMillan L, Wang W, Parker J, Rusyn I, Threadgill D. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. In: ISMB/ECCB 2007 Conference Proceedings 21-25 July 2007, Vienna, Italy. Bioinformatics 2007;23(13):i401-i407. R832720 (2007)
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Proceedings Wang W, Zhang X, Pan F. CARE:finding local linear correlations in high dimensional data. In: Proceedings of the 24th International Conference on Data Engineering, Cancun, Mexico, April 7-12, 2008. R832720 (2007)
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Proceedings Zhang M, Wang W, Liu J. Mining approximate order preserving clusters in the presence of noise. In: Proceedings of the 24th International Conference on Data Engineering, Cancun, Mexico, April 7-12, 2008. R832720 (2007)
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Proceedings Zhang X, Wang W. Mining coherent patterns from heterogeneous microarray data. In:Proceedings of the 15th Association for Computer Machinery Conference on Information and Knowledge Management, Arlington, VA, November 6-11, 2006. R832720 (2006)
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Proceedings Zhang X, Wang W, Huan J. On demand phenotype ranking through subspace clustering. In: Proceedings of the 2007 SIAM International Conference on Data Mining, Radisson University Hotel, Minneapolis, MN, April 26-28, 2007. R832720 (2007)
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Proceedings Zhang X, Wang W. An efficient algorithm for mining coherent patterns from heterogeneous microarrays. In: Proceedings of the 19th International Conference on Statistical and Scientific Database Management (SSDBM) 2007, Banff, Canada, July 9-11, 2007. R832720 (2007)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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