Grantee Research Project Results
Publications Details for Grant Number R835736C005
Systems Engineering & Analysis for Organotypic Culture Models
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Chemical-PDMS Binding Kinetics and Implications for Bioavailability in microfluidic Devices | LAB ON A CHIP | Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS | Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS Binding Kinetics and Implications for Bioavailability in microfluidic Devices. Lab on a Chip 2019;19(5):864-874 |
R835736C001 (2018) R835736C001 (Final) R835736C005 (2018) |
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| Journal Article | Circadian hormone control in a human-on-a-chip: in vitro biology's ignored component? | None | Cyr KJ, Avaldi OM, Wikswo JP | Cyr KJ, Avaldi OM, Wikswo JP. Circadian hormone control in a human-on-a-chip:in vitro biology’s ignored component? Experimental Biology and Medicine 2017;242(17):1714-1731. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Computational modeling and simulation of genital tubercle development. | REPRODUCTIVE TOXICOLOGY | Leung MC, Hutson MS, Seifert AW, Spencer RM, Knudsen TB | Leung MC, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. |
R835736 (2015) R835736 (2016) R835736C005 (2016) |
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| Journal Article | Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. | SCIENTIFIC REPORTS | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. | None | Watson DE, Hunziker R, Wikswo JP | Watson DE, Hunziker R, Wikswo JP. Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Experimental Biology and Medicine 2017;242(16):1559-1572. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Looking to the future of organs-on-chips: interview with Professor John Wikswo. | None | Wikswo JP | Wikswo JP. Looking to the future of organs-on-chips: interview with Professor John Wikswo. Future science OA 2017;3(2):FSO163. |
R835736C005 (2017) |
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| Journal Article | Electrochemical Microphysiometry Detects Cellular Glutamate Up-take. | None | Miller DR, McClain ES, Cliffel DE | Miller DR, McClain ES, Cliffel DE. Electrochemical Microphysiometry Detects Cellular Glutamate Up-take. Journal of The Electrochemical Society 2018;165(12):G3120-G3124. |
R835736 (Final) R835736C005 (2018) R835736C005 (Final) |
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| Journal Article | Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment | BIOMICROFLUIDICS | Rogers M, Sobolik T, Schaffer DK, Samson PC, Johnson AC, Owens P, Codreanu SG, Sherrod SD, McLean JA, Wikswo JP, Richmond A | Rogers M, Sobolik T, Schaffer DK, Samson PC, Johnson AC, Owens P, Codreanu SG, Sherrod SD, McLean JA, Wikswo JP, Richmond A. Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment Biomicrofluidics 2018;12(3):034102. |
R835736C005 (Final) |
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| Patent/Patent Application | . | None | Samson PC, Schaffer DK, Reiserer RS, Schatzki L, Markov DA, Britt CM, Wikswo JP | Samson PC, Schaffer DK, Reiserer RS, Schatzki L, Markov DA, Britt CM, Wikswo JP. Pressure Regulation System, Pressure Release Valves Thereof, Passive Pressurized Fluid Reservoirs, and Applications of Same. International Patent Pending PCT/US19/47324, August 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Capactive Pumps and Multi-Throw Valves and Pump-Valve Systems and Applications of Same | None | Schaffer DK, Markov DA, Reiserer RS, McCawley LJ, Geuy MD, Britt CM, Wikswo JP | Schaffer DK, Markov DA, Reiserer RS, McCawley LJ, Geuy MD, Britt CM, Wikswo JP. Cartridge Systems, Capactive Pumps and Multi-Throw Valves and Pump-Valve Systems and Applications of Same. International Patent Pending August 2019. |
R835736C005 (Final) |
not available |
| Patent/Patent Application | Fluidic Chips, Cartridges, and Connectors for Rotary Planar Pumps and Rotary Planar Valves | None | Schaffer DK, Geuy M, Reiserer RS, Britt CM, Samson PC, Markov DA, Schatzki L, Wikswo JP | Schaffer DK, Geuy M, Reiserer RS, Britt CM, Samson PC, Markov DA, Schatzki L, Wikswo JP. Fluidic Chips, Cartridges, and Connectors for Rotary Planar Pumps and Rotary Planar Valves. U.S. Patent Pending, June 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Multichannel Pumps and Applications of Same | None | Wikswo JP, Reiserer RS, Schaffer DK, Markov DA, Britt CM | Wikswo JP, Reiserer RS, Schaffer DK, Markov DA, Britt CM. Multichannel Pumps and Applications of Same. International Patent Pending PCT/US19/47190, August 2019. |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Integrated Organ-on-Chip Systems and Applications of the Same | None | Wilkswo JP | Wilkso, John P. Integrated Organ-on-Chip Systems and Applications of the Same, US Patent, 10,078,075 B2, 2018. |
R835736C005 (2018) |
not available |
| Patent/Patent Application | Interconnections of Multiple Perfused Engineered Tissue Constructs and Microbioreactors, Multi-Microformulators and Applications of the Same | None | Wilkswo JP | Wilkso JP, Interconnections of Multiple Perfused Engineered Tissue Constructs and Microbioreactors, Multi-Microformulators and Applications of the Same. US Patent 10,023,832 B2, 2018 |
R835736C005 (2018) |
not available |
| Patent/Patent Application | Multicompartment Microfluidic Bioreactors, Cylindrical Rotary Valves and Applications of Same | None | Wilkswo JP | Wikswo et Multicompartment Microfluidic Bioreactors, Cylindrical Rotary Valves and Applications of Same. Patent Pending Serial No. 62/677,468. 2018 |
R835736C005 (2018) |
not available |
| Patent/Patent Application | System for Extensible Cell Culture, Microdialysis Imaging, and Regional Chemical Delivery and Control | None | Wilkswo JP | System for Extensible Cell Culture, Microdialysis Imaging, and Regional Chemical Delivery and Control. Patent Pending. 2018 |
R835736C005 (2018) |
not available |
| Presentation | Nanoscience and biology: connecting nano to micro and milli for in vitro interrogation and control. | None | Wikswo JP | Wikswo JP. Nanoscience and biology: connecting nano to micro and milli for in vitro interrogation and control. Presented at the NSF-sponsored Annual Nanoscale Science and Engineering Grantees Conference, Arlington, VA, December 9-10, 2015 (invited). |
R835736 (2015) R835736C005 (2015) |
not available |
| Presentation | Organs on chips: bioreactors, sensors, controls and interconnects to support constructionist biology. | None | Wikswo JP | Wikswo JP. Organs on chips: bioreactors, sensors, controls and interconnects to support constructionist biology. Presented to the Department of Biomedical Engineering, Northwestern University, Evanston, IL, April 27-28, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Hands on with organ-on-a-chip workshop. | None | Wikswo JP | Wikswo JP. Hands on with organ-on-a-chip workshop. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736C005 (2016) |
not available |
| Presentation | In vitro modeling of the blood brain barrier using complex 3D models. | None | Wikswo JP | Wikswo JP. In vitro modeling of the blood brain barrier using complex 3D models. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Organs-on-chips, metabolomics, systems biology, and closing the hermeneutic circle of biology. | None | Wikswo JP | Wikswo JP. Organs-on-chips, metabolomics, systems biology, and closing the hermeneutic circle of biology. Presented at the University of Tennessee Health Science Center, Memphis, TN, December 15, 2016 (invited). |
R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Organs on chips for drug development, toxicology, and systems biology: a distributed yet interconnected modular approach. | None | Wikswo JP | Wikswo JP. Organs on chips for drug development, toxicology, and systems biology: a distributed yet interconnected modular approach. Presented at the Organ-on-a-Chip World Congress 2016 & 3D-Culture, Boston, MA, July 7-8, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Human neurovascular unit on-a-chip: microscale systems for tissue-level response. | None | Wikswo JP | Wikswo JP. Human neurovascular unit on-a-chip: microscale systems for tissue-level response. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Cutting-edge safety—preclinical in vitro models. | None | Wikswo JP | Wikswo JP. Cutting-edge safety—preclinical in vitro models. Presented at American Society of Tropical Medicine & Hygiene (ASTMH), Atlanta, GA, November 13, 2016 (invited). |
R835736C005 (2016) |
not available |
| Presentation | Probing the complexities of biology and medicine: closing the hermeneutic circle with in vitro and in silico models. | None | Wikswo JP | Wikswo JP. Probing the complexities of biology and medicine: closing the hermeneutic circle with in vitro and in silico models. Presented at the Eighth Scientific Meeting of the TMJ Association, Bethesda, MD, September 11-13, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Hormonal modulation of organs-on-chips to recapitulate in vivo ADME tox profiles in vitro. | None | Wikswo JP | Wikswo JP. Hormonal modulation of organs-on-chips to recapitulate in vivo ADME tox profiles in vitro. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Organs-on-chips: a developer’s masterclass. | None | Wikswo JP | Wikswo JP. Organs-on-chips: a developer's masterclass. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Modular architectures and control strategies for coupled microphysiological systems. | None | Wikswo JP | Wikswo JP. Modular architectures and control strategies for coupled microphysiological systems. Presented at Eli Lilly, Indianapolis, IN, January 4, 2017 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) R835736C005 (2017) |
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| Presentation | Fitting iPSCs, 3D cell culture, tissue chips and microphysiological systems into the grand scheme of biology, medicine, pharmacology, and toxicology. | None | Wikswo JP | Wikswo JP. Fitting iPSCs, 3D cell culture, tissue chips and microphysiological systems into the grand scheme of biology, medicine, pharmacology, and toxicology. Presented at the Select Biosciences Organ-on-a-Chip World Congress & 3D-Culture Conference, Boston. MA, July 10, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Scientific and technical strengths and limitations of MPS for drug toxicity testing. | None | Wikswo JP | Wikswo JP. Scientific and technical strengths and limitations of MPS for drug toxicity testing. Presented at The Toxicology Forum 43rd Annual Summer Meeting, Annapolis, MD, July 12, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Analytical chemistry for understanding the physiology and pathology of 3D cellular models. | None | Wikswo JP | Wikswo JP. Analytical chemistry for understanding the physiology and pathology of 3D cellular models. Presented at the World Preclinical Congress, Boston, MA, June 13-15, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Multichannel microformulators suitable for massively parallel automated design of biological experiments. | None | Wikswo JP | Wikswo JP. Multichannel microformulators suitable for massively parallel automated design of biological experiments. Presented at the American Physical Society Meeting, New Orleans, LA, March 13-17, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Organs on chips for drug discovery and development. | None | Wikswo JP | Wikswo JP. Organs on chips for drug discovery and development. Preseneted at the Eli Lilly Grand Rounds, Indianapolis, IN, March 22, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | Topologies, analytics, and automation for microphysiological systems. | None | Wikswo JP | Wikswo JP. Topologies, analytics, and automation for microphysiological systems. Presented at the Select Biosciences Organ-on-a-Chip Europe Conference, Munich, Germany, May 10-11, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | The opportunities and challenges of engineered models of cancer:cells, hardware, analytics, and interpretation. | None | Wikswo JP | Wikswo JP. The opportunities and challenges of engineered models of cancer: cells, hardware, analytics, and interpretation. Presented at the Physical Sciences-Oncology Network Annual Investigators Meeting, Cambridge, MA, October 17-19, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | Strengths, limitations and applications of microphysiological systems for drug development. | None | Wikswo JP | Wikswo JP. Strengths, limitations and applications of microphysiological systems for drug development. Presented at the FDA Toxicology Working Group Meeting, Washington, DC, October 26, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Functional coupling of human microphysiological systems. | None | Wikswo JP | Wikswo JP. Functional coupling of human microphysiological systems. Presented at the Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Washington, DC, October 5-6, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | S. | None | International Organ-on-Chip Workshop:From Systems Biology to Societal Issues (Milan); Biomedical Advanced Research Development Authority (BARDA) TechWatch; Gordon Conference on Cellular and Molecular Mechanisms of Toxicology; 4th PREDiCT 3D Tissue Models Summit; Briefing for the U | International Organ-on-Chip Workshop:From Systems Biology to Societal Issues (Milan); Biomedical Advanced Research and Development Authority (BARDA) TechWatch; Gordon Conference on Cellular and Molecular Mechanisms of Toxicology; 4th PREDiCT 3D Tissue Models Summit; Briefing for the U.S. Army Combat Capabilities Development Command Chemical Biological Center (CCDC-CBC), Vander-bilt; SelectBIO Organ-on-a-Chip World Congress; NIH Workshop on Tissue Chip Platforms as Tools for Testing Biocompatibility and Biotoxicity of Biomaterials; 2019 Chemical and Biological Defense Science & Technology (CBD S&T) Conference; FDA Internal MPS and Stem Cell User Group. |
R835736C005 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.