Grantee Research Project Results
Publications Details for Grant Number R835738C002
Organotypic Model of Human Kidney as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
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Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Book Chapter | Excretory processes in toxicology: drug transporters in drug development. | None | Van Ness K, Kelly E | Van Ness K, Kelly E. Excretory processes in toxicology:drug transporters in drug development. In:McQueen CA, ed. Comprehensive Toxicology, Third Edition. Volume 1:General Principles, Oxford, UK:Elsevier Ltd., 2018, Chapter 8, pp. 143-164. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. | DRUG METABOLISM AND DISPOSITION | Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G | Bajaj, P., Chowdhury SK, Yucha R, Kelly EJ and Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metabolism and Disposition 2018: 46(11);1692-1702. |
R835738C001 (2018) R835738C002 (2018) |
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| Journal Article | Liver and kidney on chips: micro-physiological models to understand transporter function. | CLINICAL PHARMACOLOGY & THERAPEUTICS | Chang S-Y, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ | Chang S-Y, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ. Liver and kidney on chips: microphysiological models to understand transporter function. Clinical Pharmacology & Therapeutics 2016;100(5):464-478. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C003 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. | None | Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL | Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight 2017;2(22):95978 (15 pp.). |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Journal Article | Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. | TOXICOLOGY IN VITRO | Chang S-Y, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL | Chang S-Y, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology In Vitro 2017;40:170-183. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C003 (2016) R835738C003 (2017) |
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| Journal Article | A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS | Monteiro, M. B., Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. Journal of the American Society of Nephrology 2018:29(12);2820-2833. |
R835738C001 (2018) R835738C002 (2018) |
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| Journal Article | Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. | None | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2017;2(21):e94929 (18 pp.). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. | SCIENTIFIC REPORTS | Sakolish C, Weber EJ, Kelly EJ, Hummelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Chiu WA, Rusyn I | Sakolish, C., Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I. Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Scientific Reports 2018: 8(1);14882 |
R835738C001 (2018) R835738C002 (2018) |
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| Journal Article | Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. | None | Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ | Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ. Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. FASEB Journal 2017;31(10):4600-4611. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
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| Journal Article | Microphysiological systems to assess nonclinical toxicity. | None | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological systems to assess nonclinical toxicity. Current Protocols in Toxicology 2017;73(1):14.18.1-14.18.28. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2018) R835738C005 (2017) |
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| Journal Article | Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. | None | Vernetti LA, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA,Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J,Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M,Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736 (2017) R835736C004 (2018) R835738C002 (2017) R835738C005 (2017) |
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| Journal Article | Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. | None | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (14 pp.). |
R835736C004 (2017) R835738 (2017) R835738C002 (2016) |
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| Journal Article | Corrigendum: Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. | SCIENTIFIC REPORTS | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Corrigendum: Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:44517. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
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| Journal Article | Development of a microphysiological model of human kidney proximal tubule function. | KIDNEY INTERNATIONAL | Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ | Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International 2016;90(3):627-637. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
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| Journal Article | Concise review: current and emerging biomarkers of nephrotoxicity. | CURRENT OPINION IN TOXICOLOGY | Weber EJ, Himmelfarb J, Kelly EJ | Weber EJ, Himmelfarb J, Kelly EJ. Concise review: current and emerging biomarkers of nephrotoxicity. Current Opinion in Toxicology 2017;4:16-21. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Journal Article | Excretory Processes in Toxicology:Drug Transporters in Drug Development. | None | Van Ness, K, & Kelly, E | Van Ness, K, & Kelly, E. Excretory Processes in Toxicology:Drug Transporters in Drug Development. In:McQueen, C. A., Comprehensive Toxicology, (2018) Third Edition. Vol. 1, pp. 143–164. Oxford:Elsevier Ltd. |
R835738C002 (2018) |
not available |
| Journal Article | Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ. Human Kidney on a Chip Assessment of Polymyxin Antibiotic Nephrotoxicity. JCI Insight 2018;:3(24): e123673. | None | Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ | Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ. “Human Kidney on a Chip Assessment of Polymyxin Antibiotic Nephrotoxicity” JCI Insight:3(24) e123673. |
R835738C002 (2018) |
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| Presentation | Development of human organotypic culture systems to model airway biology. | None | Altemeier WA | Altemeier WA. Development of human organotypic culture systems to model airway biology. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 21, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Microphysiological systems to identify organ-organ interactions in toxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. | None | Chang SY, Weber E, Kelly EJ, Eaton DL | Chang SY, Weber E, Kelly EJ, Eaton DL. Microphysiological systems to identify organ-organ interactions in toxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Pacific Northwest Association of Toxicologists Annual Meeting, Woodinville, WA, September 17-18, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
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| Presentation | Microphysiological Systems (MPS) to identify organ-organ interactions in tToxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. | None | Chang SY, Weber E, Neumann T, Kelly EJ, Eaton DL | Chang SY, Weber E, Neumann T, Kelly EJ, Eaton DL. Microphysiological Systems (MPS) to identify organ-organ interactions in tToxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C003 (2015) R835738C005 (2017) |
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| Presentation | New frontiers for linked microphysiological systems: integrated liver-kidney systems on a chip. | None | Eaton D | Eaton D. New frontiers for linked microphysiological systems: integrated liver-kidney systems on a chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
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| Presentation | Testicular cells co-culture as an alternative model for male reproductive toxicity. | None | Faustman EM | Faustman EM. Testicular cells co-culture as an alternative model for male reproductive toxicity. Presented workshop at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) |
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| Presentation | Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials. | None | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials. Poster presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials: results from the University of Washington Predictive Toxicology Center (PTC). | None | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials: results from the University of Washington Predictive Toxicology Center (PTC). Poster presented at the Society of Toxicology Contemporary Concepts in Toxicology's FutureTox III: Bridges for Translation Conference, Arlington, VA, November 19-20, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. | None | Faustman EM | Faustman EM. Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
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| Presentation | Using systems biology for linking genes and environment for alcohol research. | None | Faustman EM | Faustman EM. Using systems biology for linking genes and environment for alcohol research. Presented at the Fetal Alcohol Spectrum Disorders Study Group Meeting, Denver, CO, June 24, 2017 (keynote speaker). |
R835738 (2017) R835738C002 (2017) R835738C004 (2018) |
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| Presentation | Using systems based approaches for refinement, integration and translation. | None | Faustman E, French E, Eaton D, Kelly E, Kavanagh T | Faustman E, French E, Eaton D, Kelly E, Kavanagh T. Using systems based approaches for refinement, integration and translation. Minicourse presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2018) R835738C003 (2018) |
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| Presentation | MPS-related research. | None | Faustman E, Weber E | Faustman E, Weber E. MPS-related research. Presented to high school students (typically in STEM programs) on a monthly basis in collaboration with UW Medical Center Community Outreach, Seattle, WA, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Presentation | Educational tools for designing safer chemicals and predicting toxicity. | None | Kavanagh T | Kavanagh T. Educational tools for designing safer chemicals and predicting toxicity. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
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| Presentation | Experiences with collaborative cross for assessing gene X environment interactions for engineered nanomaterials:can we capture human variability in vitro-lessons from the Predictive Toxicology Center. | None | Kavanagh T | Kavanagh T. Experiences with collaborative cross for assessing gene X environment interactions for engineered nanomaterials: can we capture human variability in vitro-lessons from the Predictive Toxicology Center. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C003 (2018) R835738C005 (2017) |
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| Presentation | Kidney on a chip: from toxicology to therapeutics. | None | Kelly EJ | Kelly EJ. Kidney on a chip: from toxicology to therapeutics. Presented at the American Society of Nephrology Annual Meeting, San Diego, CA, November 3-8, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | Development of a 3D human kidney microphysiological system for drug safety testing. | None | Kelly EJ | Kelly EJ. Development of a 3D human kidney microphysiological system for drug safety testing. Presented at the Functional Analysis & Screening Technologies (FAST) Congress, Boston, MA, November 9-11, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | Human kidney microphysiological system for drug and xenobiotic toxicity testing. | None | Kelly EJ | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the 20th Meeting of the North American International Society for the Study of Xenobiotics (ISSX) Annual Meeting, Orlando, FL, October 18-22, 2015 (Symposium Chair). |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | Human kidney microphysiological system for drug and xenobiotic toxicity testing. | None | Kelly EJ | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the University of California, San Francisco, CA, October 27, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | 3D culture system for in vitro nephrotoxicity testing. | None | Kelly EJ | Kelly EJ. 3D culture system for in vitro nephrotoxicity testing. Presented at Bayer Corporation, San Francisco, CA, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | The 3 R’s of toxicology and the role of microphysiological systems. | None | Kelly EJ | Kelly EJ. The 3 R’s of toxicology and the role of microphysiological systems. Presented at the Institute for Stem Cell and Regenerative Medicine (ISCRM) Seminar Series, Seattle, WA, December 13, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
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| Presentation | Utility of predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. | None | Kelly EJ | Kelly EJ. Utility of predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. Presented at the Environmental Pathology/Toxicology (EP/T) Training Grant Winter Symposium, Seattle, WA, December 2, 2016 (keynote speaker). |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
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| Presentation | Predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. | None | Kelly EJ | Kelly EJ. Predictive toxicity testing in a 3D microphysiological model of the human kidney proximal tubule. Presented at the Cambridge Healthtech Institute’s (CHI) 14th Annual High Content Analysis & 3D Screening Conference: Organ-on-a-Chip, Boston, MA, October 31, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
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| Presentation | Organs on chips and reducing the need for animal studies. | None | Kelly EJ | Kelly EJ. Organs on chips and reducing the need for animal studies. Presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) R835738C005 (2017) |
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| Presentation | Human kidney microphysiological system for drug and xenobiotic toxicity testing. | None | Kelly EJ | Kelly EJ. Human kidney microphysiological system for drug and xenobiotic toxicity testing. Presented at the University of Washington, School of Public Health, Seattle, WA, 2016. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
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| Presentation | Identification and discrimination of cellular responses to new molecular entities utilizing a 3D model of the human kidney proximal tubule. | None | Kelly EJ | Kelly EJ. Identification and discrimination of cellular responses to new molecular entities utilizing a 3D model of the human kidney proximal tubule. Presented at the 10th World Congress on Alternatives and Animals in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Presentation | Predictive toxicity testing in a microphysiological model of the human kidney proximal tubule. | None | Kelly EJ | Kelly EJ. Predictive toxicity testing in a microphysiological model of the human kidney proximal tubule. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
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| Presentation | Preclinical approaches for addressing complex human health issues:aristolochic acid nephropathy. | None | Kelly EJ | Kelly EJ. Preclinical approaches for addressing complex human health issues: aristolochic acid nephropathy. Presented at the BRIDG Retreat, Seattle, WA, January 6, 2017 (keynote speaker). |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
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| Presentation | Emergent technologies for evaluating drug and xenobiotic disposition. | None | Kelly EJ | Kelly EJ. Emergent technologies for evaluating drug and xenobiotic disposition. Presented at the 21st North American ISSX Meeting of the International Society for the Study of Xenobiotics (ISSX), Providence, RI, September 24-28, 2017 (symposium co-chair). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C005 (2017) |
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| Presentation | Bioengineered ex vivo models of human organs for predictive toxicity testing. | None | Kelly E | Kelly E. Bioengineered ex vivo models of human organs for predictive toxicity testing. Presented at the New England Drug Metabolism Discussion Group Meeting, Walkersville, MD, December 6, 2017 |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) R835738C003 (2018) R835738C005 (2017) |
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| Presentation | Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. | None | Klieforth B, Shaffer RM, mith M, Faustman EM | Klieforth B, Shaffer RM, Smith M, Faustman EM. Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
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| Presentation | Evaluation of antisense oligonucleotide nephrotoxicity using a 3D microphysiological system. | None | Lidberg KA, Iversen PL, Himmelfarb J, Kelly EJ | Lidberg KA, Iversen PL, Himmelfarb J, Kelly EJ. Evaluation of antisense oligonucleotide nephrotoxicity using a 3D microphysiological system. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) |
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| Presentation | Optimization of airway epithelium organotypic culture models as a platform for adverse outcome pathway assessment of engineered nanomaterials. | None | Nicholas T, Haick A, Faustman E, Altemeier WA | Nicholas T, Haick A, Faustman E, Altemeier WA. Optimization of airway epithelium organotypic culture models as a platform for adverse outcome pathway assessment of engineered nanomaterials. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
not available |
| Presentation | Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. | None | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA. Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C001 (2016) R835738C002 (2017) |
not available |
| Presentation | Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. | None | Shaffer R, Wilder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM | Shaffer R, Wilder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Using in vitro data to compare endocrine disruption potential in hazardous chemicals currently found in children’s products and their proposed alternatives. | None | Smith MN, Shaffer RM, Cohen Hubal E, Faustman EM. | Smith MN, Shaffer RM, Cohen Hubal E, Faustman EM. Using in vitro data to compare endocrine disruption potential in hazardous chemicals currently found in children’s products and their proposed alternatives. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Nephrotoxicity of engineered nanoparticles: exposure effects of silver nanoparticles in a kidney microphysiological system. | None | Van Ness KP, Weber EJ, Neumann T, Kelly EJ | Van Ness KP, Weber EJ, Neumann T, Kelly EJ. Nephrotoxicity of engineered nanoparticles: exposure effects of silver nanoparticles in a kidney microphysiological system. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. | None | Van Ness KP, Kavanagh TJ, Kelly EJ | Van Ness KP, Kavanagh TJ Kelly EJ. Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. | None | Van Ness KP, Kavanagh TJ, Kelly EJ | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. | None | Van Ness KP, Kavanagh TJ, Kelly EJ | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. | None | Van Ness KP, Kavanagh TJ Kelly EJ | Van Ness KP, Kavanagh TJ Kelly EJ. Microphysiological system assessment of nephrotoxicity of quantum dot with a cadmium/selenium core. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Conference, Bothell, WA, October 1-2, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. | None | Van Ness KP, Kavanagh TJ, Kelly EJ | Van Ness KP, Kavanagh TJ, Kelly EJ. Microphysiological system assessment of nephrotoxicity of CdCl2 and quantum dots with a cadmium/selenium core. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C002 (2017) R835738C002 (2018) |
not available |
| Presentation | Sourcing of renal tubular epithelial cells from human stem cell-derived kidney organoids. | None | Weber EJ, Freedman BS, Himmelfarb J, Kelly EJ | Weber EJ, Freedman BS, Himmelfarb J, Kelly EJ. Sourcing of renal tubular epithelial cells from human stem cell-derived kidney organoids. Poster presented at the American Society of Nephrology Annual Meeting, San Diego, CA, November 3-8, 2015. |
R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Ex vivo induction of polymyxin-induced nephrotoxicity in a 3D microphysiological model of a human kidney proximal tubule. | None | Weber EJ | Weber EJ. Ex vivo induction of polymyxin-induced nephrotoxicity in a 3D microphysiological model of a human kidney proximal tubule. Presented to the Pacific Northwest Association of Toxicologists Annual Meeting, Woodinville, WA, September 17-18, 2015. |
R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Ex vivo induction of polymyxin-induced nephrotoxicity in a 3D microphysiological model of a human kidney proximal tubule. | None | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ. Ex vivo induction of polymyxin-induced nephrotoxicity in a 3D microphysiological model of a human kidney proximal tubule. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2015) R835738C002 (2017) |
not available |
| Presentation | Safety assessment of Polymyxin B structural variants using a 3D nephrotoxin-sensitive microphysiological system. | None | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ | Weber EJ, Vaara M, Vaara T, Neumann T, Himmelfarb J, Kelly EJ. Safety assessment of Polymyxin B structural variants using a 3D nephrotoxin-sensitive microphysiological system. Presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2016) R835738C002 (2017) |
not available |
| Presentation | Polycationic antibiotic exposure validates clinical findings using a 3D microphysiological kidney-on-a-chip. | None | Weber E, Vaara M,Vaara T, Neumann T, Himmelfarb J, Kelly E | Weber E, Vaara M,Vaara T, Neumann T, Himmelfarb J, Kelly E. Polycationic antibiotic exposure validates clinical findings using a 3D microphysiological kidney-on-a-chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C002 (2017) |
not available |
| Presentation | “Pathophysiological Responses of Proximal Tubule Epithelial Cells to Human Serum” 2018 Kidney International. | None | Lidberg KA, Patel R, Kelly EJ | Lidberg KA, Patel R, Kelly EJ. “Pathophysiological Responses of Proximal Tubule Epithelial Cells to Human Serum” 2018 Kidney International. |
R835738C002 (2018) |
not available |
| Symposium | . | None | Ed Kelly, Symposium Co-Chair, 2017 North American Annual ISSX Annual Meeting, Providence, RI, Emergent Technologies for Evaluating Drug Xenobiotic Disposition | Kelly E. Symposium Co-Chair of the 21st North American ISSX Meeting, Emergent Technologies for Evaluating Drug and Xenobiotic Disposition, Providence, RI, September 24-28, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C005 (2017) R835738C005 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.