Grantee Research Project Results
Publications Details for Grant Number R835802
Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments
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Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCastTM high-throughput data. | None | Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA | Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCastTM high-throughput data. Environmental Health Perspectives 2016;124(8):1141-1154. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | Challenges and opportunities in the risk assessment of existing substances in Canada: lessons learned from the international community. | None | Barton-Maclaren TS, Westphal M, Sarwar E, Mattison D, Chiu WA, Dix D, Kavlock R, Krewski D | Barton-Maclaren TS, Westphal M, Sarwar E, Mattison D, Chiu WA, Dix D, Kavlock R, Krewski D. Challenges and opportunities in the risk assessment of existing substances in Canada: lessons learned from the international community. International Journal of Risk Assessment and Management 2017;20;(1-3):261-283. |
R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. | CLINICAL PHARMACOLOGY AND THERAPEUTICS | Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS,Anson B, Rusyn I, Chiu WA | Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Clinical Pharmacology and Therapeutics 2019;105:1175-1186. |
R835802 (2018) R835802C001 (2018) |
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| Journal Article | A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability | None | Blanchette A, Burnett S, Rusyn I, Chiu W | Blanchette A, Burnett S, Rusyn I, Chiu W. A tiered approach to population-based in vitro testing for cardiotoxicity:Balancing estimates of potency and variability. Journal of Pharmacological and Toxicological Methods 01;119(107154). |
R835802 (2020) |
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| Journal Article | A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model | None | Blanchette A, Burnett S, Grimm F, Rusyn I, Chiu W | Blanchette A, Burnett S, Grimm F, Rusyn I, Chiu W. A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model. Toxilogical Sciences 2020;178(2):391-403. |
R835802 (2019) |
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| Journal Article | APROBA-Plus: a probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. | None | Bokkers BGH, Mengelers MJ, Bakker M, Chiu WA, Slob W | Bokkers BGH, Mengelers MJ, Bakker MI, Chiu WA, Slob W. APROBA-Plus: a probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. Food and Chemical Toxicology. 2017;110:408-417. |
R835802 (2017) R835802 (2018) |
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| Journal Article | A new approach method for characterizing inter-species toxicodynamic variability | None | Burnett S, Karmakar M, Murphy W, Chiu W, Rusyn I | Burnett S, Karmakar M, Murphy W, Chiu W, Rusyn I. A new approach method for characterizing inter-species toxicodynamic variability. Journal of Toxicology and Environmental Health, Part A 2021;. |
R835802 (2020) |
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| Journal Article | Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes | FOOD AND CHEMICAL TOXICOLOGY | Ceballos D, Luo Y, Chen Z, Blanchette A, Zhou Y, Wright F, Baker E, Chiu W, Rusyn I | Ceballos D, Luo Y, Chen Z, Blanchette A, Zhou Y, Wright F, Baker E, Chiu W, Rusyn I. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes. Food and Chemical Toxicology 2021;149:111979. |
R835802 (2019) |
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| Journal Article | A tiered, Bayesian approach to estimating population variability for regulatory decision-making. | None | Chiu WA, Wright FA, Rusyn I | Chiu WA, Wright FA, Rusyn I. A tiered, Bayesian approach to estimating population variability for regulatory decision-making. ALTEX 2017;34(3):377-388. |
R835166 (2016) R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. | None | Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, PaoliG | Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli G. Beyond the RfD:Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. Environmental Health Perspective 2018;126(6):067009. |
R835802 (2018) R835802C001 (2018) |
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| Journal Article | Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups | None | Chiu W, Guyton KZ, Martin MT, Reif DM, Rusyn I | Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 2018;35(1):51-64. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
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| Journal Article | Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. | None | Chiu WA, Rusyn I | Chiu WA, Rusyn I. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mammalian Genome 2018;29(1-2):182-189. |
R835802 (2017) R835802 (2018) |
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| Journal Article | The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. | None | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWos | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. Environmental Health Perspectives 2016;124(11):1671-1682. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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| Journal Article | Advancements in life cycle human exposure and toxicity characterization. | ENVIRONMETNAL HEALTH PERSPECTIVE | Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, ErnstoffA,Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, MillerA,Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, ValleroD,Wambaugh J, Wetmore BA, Zaleski R, McKone TE | Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, Miller A, Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. Advancements in life cycle human exposure and toxicity characterization. Environmetnal Health Perspective 2018;126:125001. |
R835802 (2018) R835802C001 (2018) |
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| Journal Article | Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types | TOXICOLOGY | Ford L, Lin H, Tsai H, Zhou Y, Wright F, Sedykh A, Shah R, Chiu W, Rusyn I | Ford L, Lin H, Tsai H, Zhou Y, Wright F, Sedykh A, Shah R, Chiu W, Rusyn I. Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types. TOXICOLOGY 2024;503(153763). |
R835802 (Final) |
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| Journal Article | Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. | None | Garbutt TA, Konneker TI, Konganti K, Hillhouse AE, Swift-Haire F, JonesA, Phelps D, Aylor DL, Threadgill D | Garbutt TA, Konneker TI, Konganti K, Hillhouse AE, Swift-Haire F, Jones A, Phelps D, Aylor DL, Threadgill D. Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. Scientific Reports 2018;8:14706. |
R835802 (2018) R835802C002 (2018) |
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| Journal Article | High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. | None | Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay and Drug Development Technologies 2015;13(9):529-546. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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| Journal Article | A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. | GREEN CHEMISTRY | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry 2016;18(16):4407-4419. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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| Journal Article | A human population-based organotypic in vitro model for cardiotoxicity screening. | None | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C,Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 2018;35:441-452. |
R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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| Journal Article | Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N,Rusyn I | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. |
R835166 (Final) R835802 (2018) R835802C001 (2018) |
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| Journal Article | Cardiovascular effects of polychlorinated biphenyls and their major metabolites. | None | Grimm FA, Klaren WD, Li X, Lehmler HJ, Karmakar M, Robertson LW, Chiu WA, Rusyn I | Grimm FA, Klaren WD, Li X, Lehmler HJ, Karmakar M, Robertson LW, Chiu WA, Rusyn I. Cardiovascular effects of polychlorinated biphenyls and their major metabolites.Environmental Health Perspectives 2020;128(7):077008. |
R835802 (Final) |
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| Journal Article | Advancing exposure science through chemical data curation and integration in the Comparative Toxicogenomics Database. | None | Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA, Mattingly CJ | Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA, Mattingly CJ. Advancing exposure science through chemical data curation and integration in the Comparative Toxicogenomics Database. Environmental Health Perspectives 2016;124(10):1592-1599. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | Application of the key characteristics of carcinogens in cancer hazard identification. | CARCINOGENESIS | Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT | Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 2018;39(4):614-622. |
R835802 (2017) R835802 (2018) |
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| Journal Article | A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. | None | House JS, Grimm FA, Jima DD, Zhou Y-H, Rusyn I, Wright FA | House JS, Grimm FA, Jima DD, Zhou Y-H, Rusyn I, Wright FA. A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Frontiers in Genetics 2017;8:168 (11 pp.). |
R835802 (2017) R835802 (2018) |
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| Journal Article | High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells | None | Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I | Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay and Drug Development Technologies 2017;15(6):267-279. |
R835166 (Final) R835802 (2017) R835802 (2018) |
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| Journal Article | Editor's highlight: analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. | None | Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Woodrow Setzer R, Kothya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS | Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Woodrow Setzer R, Kothya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS. Editor's highlight: Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. Toxicological Sciences 2016;152(2):323-339. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | gQTL: a web application for QTL analysis using the collaborative cross mouse genetic reference population. | None | Konganti K, Ehrlich A, Rusyn I, Threadgill DW | Konganti K, Ehrlich A, Rusyn I, Threadgill DW. gQTL:a web application for QTL analysis using the collaborative cross mouse genetic reference population. G3:Genes, Genomes, Genetics 2018;8(8):2559-2562 |
R835802 (2017) R835802 (2018) R835802C001 (2018) R835802C002 (2018) |
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| Journal Article | An empirical Bayes approach for multiple tissue eQTL analysis. | BIOSTATISTICS | Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB | Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB. An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics 2018;19(3):391-406. |
R835802 (2017) R835802 (2018) |
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| Journal Article | Key Characteristics of Cardiovascular Toxicants | ENVIRONMENTAL HEALTH PERSPECTIVES | LInd L, Araujo J, Barchosky A, Belcher S, Berridge B, Chiamvimonvat N, Chiu W, Cogliano V, Elmore S, Farraj A | LInd L, Araujo J, Barchosky A, Belcher S, Berridge B, Chiamvimonvat N, Chiu W, Cogliano V, Elmore S, Farraj A. Key Characteristics of Cardiovascular Toxicants. Environmental Health Perspectives 2021;129(9). |
R835802 (2020) |
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| Journal Article | Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol | None | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling:A case study with the mycotoxin deoxynivalenol. ENVIRONMENT INTERNATIONAL 2023;182(108326). |
R835166 (Final) R835802 (Final) |
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| Journal Article | Reducing uncertainty in dose-response assessments by incorporating Bayesian benchmark dose modeling and in vitro data on population variability | RISK ANALYSIS | Lu E, Ford L, Rusyn I, Chiu W | Lu E, Ford L, Rusyn I, Chiu W. Reducing uncertainty in dose-response assessments by incorporating Bayesian benchmark dose modeling and in vitro data on population variability. RISK ANALYSIS 2024; |
R835802 (Final) R840450 (2023) |
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| Journal Article | ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. | BMC BIOINFORMATICS | Marvel SW, To K, Grimm FA, Wright FA, Rusyn , Reif DM | Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 2018;19(1):80 (7 pp.). |
R835802 (2017) R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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| Journal Article | The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. | None | Rusyn I, Green N | Rusyn I, Greene N. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicological Sciences 2018;161(2):276-284. |
R835802 (2017) R835802 (2018) |
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| Journal Article | Using ToxCast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. | None | Shah I, Woodrow Setzer R, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ | Shah I, Setzer RW, Jack J, Houck KA, Judson RS, Knudsen TB, Liu J, Martin MT, Reif DM, Richard AM, Thomas RS, Crofton KM, Dix DJ, Kavlock RJ. Using ToxCast™ data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. Environmental Health Perspectives 2016;124(7):910-919. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. | None | Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR | Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicology and Applied Pharmacology 2017;322:60-74. |
R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina. | None | Tilley SK, Reif DM, Fry RC | Tilley SK, Reif DM, Fry RC. Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina. Environment International 2017;101:19-26. |
R835802 (2017) R835802 (2018) |
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| Journal Article | Conditional Toxicity Value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. | ENVIRON HEALTH PERSPECT | Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA | Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. Conditional Toxicity Value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environmental Health Perspectives 2018;126(5):057008 (13 pp.). |
R835802 (2017) R835802 (2018) |
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| Journal Article | Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. | REPRODUCTIVE TOXICOLOGY | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reproductive Toxicology 2016;62:92-99. |
R835168 (Final) R835796 (2017) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. | None | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicology and Applied Pharmacology 2017;314:109-117. |
R835796 (2017) R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | Computation of ancestry scores with mixed families and unrelated individuals. | None | Zhou Y-H, Marron JS, Wright FA | Zhou Y-H, Marron JS, Wright FA. Computation of ancestry scores with mixed families and unrelated individuals. Biometrics 2018;74(1):155-164. |
R835802 (2016) R835802 (2017) R835802 (2018) |
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| Journal Article | Concentration–response evaluation of ToxCast compounds for multivariate activity patterns of neural network function. | ARCHIVES OF TOXICOLOGY | Kosnik MB, Strickland JD, Marvel SW, Wallis DJ, Wallace K, Richard AM, Reif DM, Shafer TJ | Kosnik MB, Strickland JD, Marvel SW, Wallis DJ, Wallace K, Richard AM, Reif DM, Shafer TJ. Concentration–response evaluation of ToxCast compounds for multivariate activity patterns of neural network function. ARCHIVES OF TOXICOLOGY 2013;94:469-484. |
R835802 (2019) |
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| Journal Article | HT-eQTL:integrative expression quantitative trait loci analysis in a large number of human tissues. | BMC BIOINFORMATICS | Li G, Jima D, Wright FA, Nobel AB | Li G, Jima D, Wright FA, Nobel AB. HT-eQTL:integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 2018;19:95. |
R835802 (2018) R835802C003 (2018) |
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| Journal Article | Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. | None | Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I | Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX-Alternatives to Animal Experimentation 2020; 37(4):623-638 |
R835802 (2019) |
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| Journal Article | Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. | FRONTIERS IN PHARMACOLOGY | Hsieh NH, Reisfeld, B, Bois FY, Chiu WA | Hsieh NH, Reisfeld, B, Bois FY, Chiu WA. Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Frontiers in Pharmacology 2018 9:588. |
R835802 (2018) R835802C001 (2018) |
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| Presentation | An in vitro human Bayesian Population Pharmacodynamic Model for predicting effects on heart rhythm. | None | Blanchette A, Dalaijamts C, Grimm FA, Ferguson K, Anson B, Rusyn I, Chiu WA | Blanchette A, Dalaijamts C, Grimm FA, Ferguson K, Anson B, Rusyn I Chiu WA. An in vitro human Bayesian Population Pharmacodynamic Model for predicting effects on heart rhythm. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers STAR Grantee Annual Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) |
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| Presentation | Initial characterization of hepatocytes derived from Collaborative Cross recombinant inbred mouse strain iPSCs. | None | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill DW, Kavanagh TJ | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill DW, Kavanagh TJ. Initial characterization of hepatocytes derived from Collaborative Cross recombinant inbred mouse strain iPSCs. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers STAR Grantee Annual Meeting, Durham, NC, 2018. |
R835802 (2017) |
not available |
| Presentation | Use of high throughput screening data in IARC monograph evaluations. | None | Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I | Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. Use of high throughput screening data in IARC monograph evaluations. Poster presented at the 50th Anniversary Meeting of the International Agency for Research on Cancer, Lyon, France, June 7-10, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Advancing risk assessment with genetic and population variability data. | None | Chiu WA | Chiu WA. Advancing risk assessment with genetic and population variability data. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Probabilistic dose-response assessment: basic principles and general approach developed by the WHO/IPCS. | None | Chiu WA | Chiu WA. Probabilistic dose-response assessment: basic principles and general approach developed by the WHO/IPCS. Poster presented at Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Addressing uncertainty, variability, susceptibility and risk in the 21st Century: the union of two NAS reports? | None | Chiu WA | Chiu WA. Addressing uncertainty, variability, susceptibility and risk in the 21st Century: the union of two NAS reports? Presented at the Society of Toxicology, Occupational and Public Health Specialty Section Luncheon, New Orleans, LA, March 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Addressing population variability and susceptibility in risk assessment. | None | Chiu WA | Chiu WA. Addressing population variability and susceptibility in risk assessment. Presented at the Risk Assessment of Tobacco Products: A Public Workshop, Hyattsville, MD, November 15-16, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Next generation human health decision-making incorporating population and inter-individual variability. | None | Chiu WA | Chiu WA. Next generation human health decision-making incorporating population and inter-individual variability. Poster presented at the Society for Risk Analysis Annual Meeting, San Diego, CA, December 11-15, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
|
| Presentation | Challenges and opportunities in using IVIVE to quantify risk and improve decision-making. | None | Chiu WA | Chiu WA. Challenges and opportunities in using IVIVE to quantify risk and improve decision-making. Presented at the 10th Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20-24, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | A probabilistic hazard characterization framework for addressing uncertainty and variability. | None | Chiu WA | Chiu WA. A probabilistic hazard characterization framework for addressing uncertainty and variability. Presented at the National Academy of Sciences: Workshop on the Development of Guiding Principles for the Inclusion of Chronic Disease Endpoints in Future Dietary Reference Intake, Washington, DC, January 9, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Using ToxCast data in support of the key characteristics of carcinogens: opportunities and Challenges. | None | Chiu, WA | Chiu, WA. Using ToxCast data in support of the key characteristics of carcinogens: opportunities and Challenges. Presented at the Toxicology Forum 42nd Annual Winter Meeting, Washington, DC, January 29-31, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Broad application of a probabilistic dose-response framework to improve chemical risk assessment. | None | Chiu WA, Ouyang O, Dalaijamts C, Axelrad DA, Dockins C, Paoli G | Chiu WA, Ouyang O, Dalaijamts C, Axelrad DA, Dockins C, Paoli G. Broad application of a probabilistic dose-response framework to improve chemical risk assessment. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. | None | Chiu W | Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Laboratory Animal Sciences Virtual Event. Online Conference by Labroots, Inc. February 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read across. | None | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I. Categorization of UVCBs using chemical-biological read across. Society of Toxicology Annual Meeting, New Orleans, LA, 2016. |
R835802 (2018) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read across. | None | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I. Categorization of UVCBs using chemical-biological read across. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
| Presentation | A population-based organotypic human in vitro model for cardiotoxicity testing. | None | Grimm FA, Chiu W, Hsieh NH, Dalaijamts C, Burnett S, Anson B, Wright A, Wright F, Rusyn I. | Grimm FA, Chiu W, Hsieh NH, Dalaijamts C, Burnett S, Anson B, Wright A, Wright F, Rusyn I. A population-based organotypic human in vitro model for cardiotoxicity testing. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Diversity in a dish: a human population-based organotypic in vitro model for cardiotoxicity testing. | None | Grimm FA | Grimm FA. Diversity in a dish: a human population-based organotypic in vitro model for cardiotoxicity testing. Presented via the Society of Toxicology: In Vitro and Alternative Methods Specialty Section Webinar Series, May 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Cardiotoxicity screening of polychlorinated biphenyls and their major metabolites. | None | Grimm FA, Klaren WK, Li X, House JS, Chiu W, Lehmler HJ, Robertson LW, Rusyn I | Grimm FA, Klaren WK, Li X, House JS, Chiu W, Lehmler HJ, Robertson LW, Rusyn I. Cardiotoxicity screening of polychlorinated biphenyls and their major metabolites. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. | None | Grimm F, Iwata Y, Sirenko O, Bittner M, Rusyn I | Grimm F, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Poster presented at the Society for Biomolecular Imaging and Informatics Annual Meeting, Boston, MA, September 15-17, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
| Presentation | Diversity in a dish: a population-based organotypic in vitro model for cardiotoxicity testing. | None | Grimm F | Grimm F. Diversity in a dish: a population-based organotypic in vitro model for cardiotoxicity testing. Presented at the Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology Symposium at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | New WHO guidance on uncertainty in hazard characterization: a unified tiered approach integrating deterministic and probabilistic methods. | None | Herzler M, Chiu WA, Slob W | Herzler M, Chiu WA, Slob W. New WHO guidance on uncertainty in hazard characterization: a unified tiered approach integrating deterministic and probabilistic methods. Poster presented at the 3rd German Pharm-Tox Summit, Göttingen, Germany, February 26-March 3, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | High-throughput count based assessment of concentration response modeling and gene expression. | None | House JS, Grimm FA, Jima D, Zhou YH, Rusyn I, Wright FA | House JS, Grimm FA, Jima D, Zhou YH, Rusyn I, Wright FA. High-throughput count based assessment of concentration response modeling and gene expression. Poster presented at the EPA Organotypic Culture STAR Grants Satellite Meeting at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Assessing inter-individual variability with high-throughput transcriptomics. | None | House JS | House JS. Assessing inter-individual variability with high-throughput transcriptomics. Presented at the Genetics and Environmental Mutagenesis Society (GEMS) Fall Symposium, Research Triangle Park, NC, November 7, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | High-throughput concentration response modeling in iPSC-cardiomyocytes. | None | House JS, Grimm FA, Jima D, Rusyn I,Wright FA | House JS, Grimm FA, Jima D, Rusyn I,Wright FA. High-throughput concentration response modeling in iPSC-cardiomyocytes. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers Annual STAR Grantee Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Pksensi: An R Package to apply sensitivity analysis in pharmacokinetic modeling. | None | Hsieh N, Chiu W, Reisfeld B. | Hsieh N, Chiu W, Pksensi R. An R Package to apply sensitivity analysis in pharmacokinetic modeling. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) |
not available |
| Presentation | Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2015) R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
| Presentation | A multi-dimensional high-throughput approach for toxicity evaluation of environmental chemicals in induced pluripotent stem cell-derived endothelial cells. | None | Iwata Y, Klaren W, Grimm FA, Rusyn I | Iwata Y, Klaren W, Grimm FA, Rusyn I. A multi-dimensional high-throughput approach for toxicity evaluation of environmental chemicals in induced pluripotent stem cell-derived endothelial cells. Poster presented at the at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Development of a high-throughput multiplexed assay for determining chemical effects on macrophage function. | None | Klaren WD, Iwata Y, Grimm F, Rusyn I | Klaren WD, Iwata Y, Grimm F, Rusyn I. Development of a high-throughput multiplexed assay for determining chemical effects on macrophage function. Poster presented at the at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Data integration techniques to elucidate connections between environmental factors, genetic variants, and human diseases. | None | Kosnik MB, Planchart A, Reif DM, Mattingly CJ | Kosnik MB, Planchart A, Reif DM, Mattingly CJ. Data integration techniques to elucidate connections between environmental factors, genetic variants, and human diseases. ASHG Annual Meeting, San Diego, CA, 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Concentration-response evaluation of ToxCast compounds for multivariate fingerprints of neural network function. | None | Kosnik MB | Kosnik MB. Concentration-response evaluation of ToxCast compounds for multivariate fingerprints of neural network function. U.S. EPA NCCT ToxCast Meeting, March 2019. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. | None | Kosnik M, Planchart A, Marvel S, Reif D, Mattingly C | Kosnik M, Planchart A, Marvel S, Reif D, Mattingly C. Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers Annual STAR Grantee Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Generation of a diverse population of murine iPSCs using Sendai virus vector. | None | Popp J | Popp J. Generation of a diverse population of murine iPSCs using Sendai virus vector. Presented at the Texas A&M Student Research Week, College Station, TX, April 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | In vitro cardiotoxicity testing using murine iPSC derived organoids from a genetic reference population. | None | Popp J | Popp J. In vitro cardiotoxicity testing using murine iPSC derived organoids from a genetic reference population. Presented at the Texas Genetics Society 44th Annual Meeting, April 27-29, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Generation and use of induced pluripotent stem cells from a genetically heterogeneous population. | None | Popp J | Popp J. Generation of a diverse population of murine iPSCs using Sendai virus vector. Presented at the Texas A&M Regenerative Medicine Interest Group Meeting, College Station, TX, June 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Embryoid body-based OCM for cardiotoxicity testing. | None | Popp J | Popp J. Embryoid body-based OCM for cardiotoxicity testing. Presented at the Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology Symposium at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Linking in vitro-to-in vivo toxicity testing using genetically-matched organoids and mice from a novel genetic reference population. | None | Popp J,Threadgill DW | Popp J, Threadgill DW. Linking in vitro-to-in vivo toxicity testing using genetically-matched organoids and mice from a novel genetic reference population. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers Annual STAR Grantee Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Searching for GxE in high-throughput data. | None | Reif DM | Reif DM. Searching for GxE in high-throughput data. Biology Seminar Series, East Carolina University Greenville, NC, October 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Leveraging the power of high-dimensional data for integrated screening and prioritization decisions. | None | Reif DM | Reif DM. Leveraging the power of high-dimensional data for integrated screening and prioritization decisions. Presented at the European Chemicals Agency's Topical Scientific Workshop, Helsinki, Finland, April 19-20, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. | None | Reif DM | Reif DM. Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Leveraging high-dimensional data to inform probabilistic dose-response estimates. | None | Reif DM | Reif DM. Leveraging high-dimensional data to inform probabilistic dose-response estimates. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Bioinformatics for linking social and environmental determinants of health. | None | Reif DM | Reif DM. Bioinformatics for linking social and environmental determinants of health. Presented at the University of Wollongong. Wollongong, Australia, April 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | SEAZIT: overview of zebrafish screening data. | None | Reif DM | Reif DM. SEAZIT: overview of zebrafish screening data. Presented at the National Institute of Environmental Health Sciences (NIEHS), Durham, NC, April 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Integrating multiple sources of high-dimensional data to quantify effects of genetic variability in chemical risk assessment. | None | Reif DM | Reif DM. Integrating multiple sources of high-dimensional data to quantify effects of genetic variability in chemical risk assessment. Presented at the 41st Annual Winter Meeting of the Toxicology Forum, Washington, DC, February 6-8, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Applying data science: basic sciences. | None | Reif DM | Reif DM. Applying data science: basic sciences. Presented at the National Institute of Environmental Health Sciences (NIEHS) Data Science Retreat, Durham, NC, July 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Implications of population genetic diversity for safety assessment. | None | Reif DM | Reif DM. Implications of population genetic diversity for safety assessment. Presented at OPENTOX USA 2017, Durham, NC, July 12-13, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Analytical methods to distill useful information from high-throughput screening of chemicals. | None | Reif DM | Reif DM. Analytical methods to distill useful information from high-throughput screening of chemicals. Presented at the Joint Meeting of the Neurotoxicity Society & International Neurotoxicology Association, Florianopolis, Brazil, May 20-24, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Gene-environment interactions associated with differential susceptibility to chemical exposure. | None | Reif DM | Reif DM. Gene-environment interactions associated with differential susceptibility to chemical exposure. Presented at the Environmental Mutagenesis and Genomics Society (EMGS) 48th Annual Meeting, Raleigh, NC, September 9-13, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Mouse vs. | None | Rusyn I | Rusyn I. Mouse vs. Machine: Are animal studies being supplanted by computers? Society of Toxicology Annual Meeting, Baltimore, MD, March 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read across. | None | Rusyn I | Rusyn I. Categorization of UVCBs using chemical-biological read across. Presented at the European Chemicals Agency's Topical Scientific Workshop, Helsinki, Finland, April 19-20, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Chemical safety assessment using read-across: novel biological and chemical profiling methodologies. | None | Rusyn I | Rusyn I. Chemical safety assessment using read-across: novel biological and chemical profiling methodologies. Presented at the International Council of Chemical Associations’ Long-Range Research Initiative (ICCA-LRI) and Japan’s National Institute of Health Sciences (NIHS) Workshop, Awaji, Japan, June 15-16, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Exploring the characterization of human variability with in vitro models. | None | Rusyn I | Rusyn I. Exploring the characterization of human variability with in vitro models. Presented at the International Conference on Toxicity Testing Alternatives & Translational Toxicology, Hangzhou, China, June 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read across. | None | Rusyn I | Rusyn I. Categorization of UVCBs using chemical-biological read across. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Genetics for toxicologists: why should we care? | None | Rusyn I | Rusyn I. Genetics for toxicologists: why should we care? Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Rusyn I | Rusyn I. Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Use of high throughput screening data in IARC monograph evaluations. | None | Rusyn I | Rusyn I. Use of high throughput screening data in IARC monograph evaluations. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Use of high throughput screening data in International Agency for Research on Cancer (IARC) monograph evaluations. | None | Rusyn I, Chiu WA, Guyton KZ, Martin M, Reif D | Rusyn I, Chiu WA, Guyton KZ, Martin M, Reif D. Use of high throughput screening data in International Agency for Research on Cancer (IARC) monograph evaluations. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2018) |
not available |
| Presentation | A chemical–biological similarity-based grouping of complex substances using multi-dimensional high-content screening of human induced pluripotent stem cell (iPSC)-derived models. | None | Rusyn I | Rusyn I. A chemical–biological similarity-based grouping of complex substances using multi-dimensional high-content screening of human induced pluripotent stem cell (iPSC)-derived models. Presented at the Environmental Mutagenesis and Genomics Society's 47th Annual Meeting, Kansas City, MO, September 24-28, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | A population-based organotypic human in vitro model for cardiotoxicity testing. | None | Rusyn I | Rusyn I. A population-based organotypic human in vitro model for cardiotoxicity testing. Presented at the 10th Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20-24, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Read-across and grouping of complex substances using bioactivity data from human induced pluripotent stem cell (iPSC)-derived models. | None | Rusyn I | Rusyn I. Read-across and grouping of complex substances using bioactivity data from human induced pluripotent stem cell (iPSC)-derived models. Presented at the 10th Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20-24, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | The future of human health assessments: using new methodologies for better understanding of the health impacts of petroleum substances. | None | Rusyn I | Rusyn I. The future of human health assessments: using new methodologies for better understanding of the health impacts of petroleum substances. Presented at the 12th Concawe Symposium, Antwerp, Belgium, March 20-21, 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Using new methodologies for better understanding of the health impacts of new and complex chemistries. | None | Rusyn I | Rusyn I. Using new methodologies for better understanding of the health impacts of new and complex chemistries. Presented via the EPA/NCER webinar, Washington, DC, May 2017. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Commercializing tissue chip technologies. | None | Rusyn I | Rusyn I. Commercializing tissue chip technologies. Presented at Organs- and Tissues-on-Chips, Big Sky, MT, April 8-12, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Grouping of UVCBs using chemical-biological read-across: case study of petroleum substances. | None | Rusyn I | Rusyn I. Grouping of UVCBs using chemical-biological read-across: case study of petroleum substances. Presented at the Toxicology Forum 42nd Annual Winter Meeting, Washington, DC, January 29-31, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Exploring the characterization of human variability with in vivo and in vitro experimental models. | None | Rusyn I | Rusyn I. Exploring the characterization of human variability with in vivo and in vitro experimental models. Presented at the University of Pennsylvania 13th Annual Center of Excellence in Environmental Toxicology (CEET) Symposium, Philadelphia, PA, June 18, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read-across. | None | Rusyn I | Rusyn I. Categorization of UVCBs using chemical-biological read-across. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | The cross-laboratory testing of the 8 human proximal tubule chip. | None | Sakolish C, Bell C, Weber E, Kelly E, Himmelfarb J, Mouneimne R, Wade T, Han A, Burghardt R, Chiu W, Rusyn I | Sakolish C, Bell C, Weber E, Kelly E, Himmelfarb J, Mouneimne R, Wade T, Han A, Burghardt R, Chiu W, Rusyn I. The cross-laboratory testing of the 8 human proximal tubule chip. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Use of the collaborative cross mouse panel to assess the effect of genetic variability in the low-dose region of a TCDD-induced dose-response curve. | None | Threadgill D | Threadgill D. Use of the collaborative cross mouse panel to assess the effect of genetic variability in the low-dose region of a TCDD-induced dose-response curve. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. | None | To K, Nguyen A, Fry RC, Reif DM | To K, Nguyen A, Fry RC, Reif DM. Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
not available |
| Presentation | Population variability and the teratogenic effects of exposure to 2,3,7,8-tetracholordibenzo-p-dioxin during pregnancy. | None | Warren MR, Threadgill DW | Warren MR, Threadgill DW. Population variability and the teratogenic effects of exposure to 2,3,7,8-tetracholordibenzo-p-dioxin during pregnancy. Poster presented at the Allied Genetics Conference, Orlando, FL, July 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C002 (2015) |
not available |
| Presentation | Data integration and visualization for transparent communication of the category read across: glycol ethers case study. | None | Wilson MR, Rowlands JC, Ball N, Wignall JA, Fourches D, Rusyn I | Wilson MR, Rowlands JC, Ball N, Wignall JA, Fourches D, Rusyn I. Data integration and visualization for transparent communication of the category read across: glycol ethers case study. Poster presented at the International Council of Chemical Associations’ Long-Range Research Initiative (ICCA-LRI) Workshop, New Orleans, LA, June 16-17, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
| Presentation | Building a bioinformatics-savvy workforce in environmental sciences. | None | Wright FA | Wright FA. Building a bioinformatics-savvy workforce in environmental sciences. Workshop on Developing a Data Science Competent EHS Workforce, NIEHS, Research Triangle Park, NC, August 2018. |
R835802 (2018) |
not available |
| Presentation | An update on eQTLs, and their tissue-specificity– what have we learned? Presented at the North Carolina State University Genetics Program Seminar Series. | None | Wright FA | Wright FA. An update on eQTLs, and their tissue-specificity– what have we learned? Presented at the North Carolina State University Genetics Program Seminar Series, October 19, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Integrative approaches for large-scale transcriptome-wide association studies. | None | Wright FA | Wright FA. Integrative approaches for large-scale transcriptome-wide association studies. Presented at the American Society of Human Genetics Annual Meeting, Baltimore, MD, October 6-10, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | Basic concepts in genetics, heritability, genome-wide association, and related toxicology study designs. | None | Wright FA | Wright FA. Basic concepts in genetics, heritability, genome-wide association, and related toxicology study designs. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
| Presentation | A TempOSeq pipeline for high throughput concentration response modeling of gene expression for toxicogenomics. | None | Wright FA | Wright FA. A TempOSeq pipeline for high throughput concentration response modeling of gene expression for toxicogenomics. Presented at the NIEHS National Toxicology Program Seminar, Research Triangle Park, NC, October 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | High-throughput count based assessment of concentration response modeling and gene expression. | None | Wright FA | Wright FA. High-throughput count based assessment of concentration response modeling and gene expression. Presented at the Peer Review of the Draft NTP Approach to Genomic Dose-Response (GDR) Modeling Workshop, Research Triangle Park, NC, October 23-25, 2017. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Next Generation Human Health Decision-Making Incorporating Population and Inter-individual Variability. | None | Chiu WA | Chiu WA. Next Generation Human Health Decision-Making Incorporating Population and Inter-individual Variability. Presented at the Society for Risk Analysis meeting, New Orleans, LA, 2016. |
R835802 (2018) |
not available |
| Presentation | Generation and Use of Induced Pluripotent Stem Cells from a Genetically Heterogeneous Population. | None | Popp J | Popp J. Generation and Use of Induced Pluripotent Stem Cells from a Genetically Heterogeneous Population. Texas A&M Regenerative Medicine Interest Group. College Station, TX, June 2017. |
R835802 (2018) |
not available |
| Presentation | A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. | None | Chen Z, Yanagisawa L, Chiu WA, Rusyn I | Chen Z, Yanagisawa L, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Presented at The Harvey Research Symposium, Corpus Christie, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | An in vitro human population model for assessment of inter-individual variability in cardiotoxicity. | None | Burnett S, Grimm F, Anson B, Wright FA, Chiu W, Rusyn I | Burnett S, Grimm F, Anson B, Wright FA, Chiu W, Rusyn I. An in vitro human population model for assessment of inter-individual variability in cardiotoxicity. Lone Star SOT Annual Meeting, Austin, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Application of the WHO-IPCS dose-response framework to the human toxicity component of life cycle impact analysis. | None | Chiu W | Chiu W. Application of the WHO-IPCS dose-response framework to the human toxicity component of life cycle impact analysis. Society for Risk Analysis Annual Meeting. Arlington, VA, December 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for non-cancer effects. | None | Chiu W | Chiu W. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for non-cancer effects. UC-SF Program on Reproductive Health and the Environment (PRHE) Rapid Response Network Meeting, November 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Data Handling and Integration. | None | Wright FA | Wright FA. Data Handling and Integration. Concawe Cat-App Workshop, Brussels, Belgium, September 2018. |
R835802 (2018) |
not available |
| Presentation | Development and use of quantitative adverse outcome pathways: lessons learned from application to cardiotoxicity. | None | Chiu W | Chiu W. Development and use of quantitative adverse outcome pathways: lessons learned from application to cardiotoxicity. National Academies of Sciences Workshop: Strategies and tools for conducting systematic reviews of mechanistic data to support chemical assessments. Washington, DC, December 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Effect-size and multitissue models for cis-eQTLs. | None | Wright FA | Wright FA. Effect-size and multitissue models for cis-eQTLs. GTEx Meeting, NY Genome Center, New York City, May 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Thorough QT/QTC in a dish: An in vitro human model that accurately predicts clinical concentration-QTC relationships. | None | Blanchette A, Grimm F, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA | Blanchette A, Grimm F, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTC in a dish: An in vitro human model that accurately predicts clinical concentration-QTC relationships. Presented at the Lone Star SOT Annual Meeting, Austin, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. | None | Chiu W | Chiu W.Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. American Society for Cellular and Computational Toxicology webinar series, November 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Using ToxCast data in support of the key characteristics of carcinogens:opportunities and challenges. | None | Chiu W | Chiu W. Using ToxCast data in support of the key characteristics of carcinogens:opportunities and challenges. California EPA Cancer and Environmental Mixtures Meeting. Oakland, CA, August 2018. |
R835802 (2018) R835802C001 (2018) |
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| Presentation | WHO/IPCS probabilistic approach to improve chemical dose-response assessments. | None | Chiu W | Chiu W. WHO/IPCS probabilistic approach to improve chemical dose-response assessments. Workshop on the Development of an Evidence Based Risk Assessment Framework. Ottawa, Canada, December 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. | None | Chen Z, Yanagisawa L, Liu Y, Camargo K, Casillas G, McDonald T, Horney J, Chiu WA, Rusyn I | Chen Z, Yanagisawa L, Liu Y, Camargo K, Casillas G, McDonald T, Horney J, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Society of Toxicology Annual Meeting, Baltimore, MD 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. | None | Chiu W | Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Department of Veterinary Physiology & Pharmacology Seminar. College Station, TX, February 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Baseline cardiac phenotypes across a diverse population of mice: Implications for cardiotoxicity risk assessment. | None | Popp J, Threadgill DW | Popp J, Threadgill DW. Baseline cardiac phenotypes across a diverse population of mice: Implications for cardiotoxicity risk assessment. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) |
not available |
| Presentation | Enabling Assessment of Cardiotoxicity Hazard for Environmental Chemicals Using An In Vitro Human Population Model. | None | Burnett S, Blanchette A, Grimm F, Wright F, Chiu W, Rusyn I | Burnett S, Blanchette A, Grimm F, Wright F, Chiu W, Rusyn I. Enabling Assessment of Cardiotoxicity Hazard for Environmental Chemicals Using An In Vitro Human Population Model. Society of Toxicology Annual Meeting, Baltimore, MD 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Evidence integration across multiple toxicity endpoints to prioritize constituents of potential concern in oil and gas produced water. | None | Danforth C, Craft E, Bolden A, Schultz K, Kwiatkowski C, Rusyn I, Chiu W | Danforth C, Craft E, Bolden A, Schultz K, Kwiatkowski C, Rusyn I, Chiu W. Evidence integration across multiple toxicity endpoints to prioritize constituents of potential concern in oil and gas produced water. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) |
not available |
| Presentation | Multi concentration screening of ToxCast compounds for neurotoxicity using microelectrode arrays. | None | Kosnik MB | Kosnik MB. Multi concentration screening of ToxCast compounds for neurotoxicity using microelectrode arrays. EPA ToxCast Meeting. RTP, NC, February 2019. |
R835802 (2018) |
not available |
| Presentation | POPKAT: A Framework for Bayesian Population PBPK Analysis. | None | Reisfeld B, Chiu W, Hsieh N, Ghosh S, Olschanowsky C, Bois F | Reisfeld B, Chiu W, Hsieh N, Ghosh S, Olschanowsky C, Bois F. POPKAT: A Framework for Bayesian Population PBPK Analysis. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Probabilistic Dose-Response Assessment Using the WHO/IPCS Framework. | None | Chiu W | Chiu W. Probabilistic Dose-Response Assessment Using the WHO/IPCS Framework. Training Workshop for California EPA/Department of Pesticide Regulation. Sacramento, CA, February 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | The Utility of Informative Prior in Benchmark Dose Modeling for Animal Reduction. | None | Shao K, Chiu WA, Shapiro A | Shao K, Chiu WA, Shapiro A. The Utility of Informative Prior in Benchmark Dose Modeling for Animal Reduction. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. | None | Chiu W | Chiu W. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Food and Drug Administration, Center for Drug Evaluation and Research, Pharmacology and Toxicology Reviewer Cardiac Journal Club, March 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
| Presentation | In vitro approaches to grouping of complex substances and UVCBs: a case study of olefin streams. | None | Klaren WD, Grimm FA, Shen H, Rusyn I | Klaren WD, Grimm FA, Shen H, Rusyn I. In vitro approaches to grouping of complex substances and UVCBs: a case study of olefin streams. Poster presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835802 (2017) R835802 (2018) |
not available |
| Presentation | Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. | None | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D Kavanagh TJ (2018) | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D and Kavanagh TJ (2018). Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. |
R835738C003 (2018) R835802 (2018) R835802C001 (2018) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.