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Grantee Research Project Results

Publications Details for Grant Number R835551

Human Neural Stem Cell Metabolomic, Cellular and Organ Level Adverse Outcome Pathway Relationships for Endocrine Active Compounds

RFA: Development and Use of Adverse Outcome Pathways that Predict Adverse Developmental Neurotoxicity (2012)

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Abstract (2)
Journal Article (7)
Presentation (23)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Abstract Determining developmental neurotoxicity of pesticides utilizing metabolomic profile from neural progenitor cells. BIRTH DEFECTS RESEARCH PART A:CLINICAL AND MOLECULAR TERATOLOGY Mckenzie M, Amosu M, Wu X, Wallace S, Henderson M, Bian X, Lu K, Stice SL, Smith MA Mckenzie M, Amosu M, Wu X, Wallace S, Henderson M, Bian X, Lu K, Stice SL, Smith MA. Determining developmental neurotoxicity of pesticides utilizing metabolomic profile from neural progenitor cells. Birth Defects Research Part A: Clinical and Molecular Teratology 2016;106(5):387 (platform abstract 6). R835551 (2016)
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Abstract GFP plus human stem cell-derived neurons amenable to high-content and high-throughput assays. INTERNATIONAL JOURNAL PF TOXICOLOGY Yeshi T, Majumder A, Crawford J, Stice SL Yeshi T, Majumder A, Crawford J, Stice S. Chengelis C. GFP plus human stem cell-derived neurons amenable to high-content and high-throughput assays. International Journal of Toxicology 2016;25(1):72 (abstract P415). R835551 (2016)
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Journal Article Tracking and quantification of single-walled carbon nanotubes in fish using near infrared fluorescence. ENVIRONMENTAL SCIENCE & TECHNOLOGY Bisesi Jr. JH, Merten J, Liu K, Parks AN, Afrooz AR, Glenn JB, Klaine SJ, Kane AS, Saleh NB, Ferguson PL, Sabo-Altwood T Bisesi Jr. JH, Merten J, Liu K, Parks AN, Afrooz AR, Glenn JB, Klaine SJ, Kane AS, Saleh NB, Ferguson PL, Sabo-Altwood T. Tracking and quantification of single-walled carbon nanotubes in fish using near infrared fluorescence. Environmental Science & Technology 2014;48(3):1973-1983. R835551 (Final)
R835580 (2014)
R835580 (2015)
R835580 (2016)
R835580 (2017)
R835580 (2018)
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Journal Article Tracking and quantification of magetically labeled stem cells using magnetic resonance imaging. None Goodfellow FT, Simchick GA, Mortensen LJ, Stice SL, Zhao Q Goodfellow FT, Simchick GA, Mortensen LJ, Stice SL, Zhao Q. Tracking and quantification of magetically labeled stem cells using magnetic resonance imaging. Advanced Functional Materials 2016;26(22):3899-3915. R835551 (2015)
R835551 (2016)
R835551 (Final)
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Journal Article High content imaging quantification of multiple in vitro human neurogenesis events after neurotoxin exposure. BMC PHARMACOLOGY AND TOXICOLOGY Wu X, Majumder A, Webb R, Stice SL Wu X, Majumder A, Webb R, Stice SL. High content imaging quantification of multiple in vitro human neurogenesis events after neurotoxin exposure. BMC Pharmacology and Toxicology 2016;17(1):62. EPD15002 (Final)
R835551 (2016)
R835551 (Final)
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Journal Article From the cover: Astrocytes are protective against chlorpyrifos developmental neurotoxicity in human pluripotent stem cell-derived astrocyte-neuron cocultures. TOXICOLOGICAL SCIENCES Wu X, Yang X, Majumder A, Swetenburg R, Goodfellow FT, Bartlett MG, Stice SL Wu X, Yang X, Majumder A, Swetenburg R, Goodfellow FT, Bartlett MG, Stice SL. From the cover: Astrocytes are protective against chlorpyrifos developmental neurotoxicity in human pluripotent stem cell-derived astrocyte-neuron cocultures. Toxicological Sciences 2017;157(2):410-420. R835551 (Final)
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Journal Article Zika virus induced mortality and microcephaly in chicken embryos. None Goodfellow FT, Tesla B, Simchick G, Zhao Q, Hodge T, Brindley MA, Stice SL Goodfellow FT, Tesla B, Simchick G, Zhao Q, Hodge T, Brindley MA, Stice SL. Zika virus induced mortality and microcephaly in chicken embryos. Stem Cells and Development 2016;25(22):1691-1697. EPD15002 (Final)
R835551 (2016)
R835551 (Final)
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Journal Article Zika virus exhibits lineage-specific phenotypes in cell culture, in Aedes aegypti mosquitoes, and in an embryo model. VIRUSES Willard KA, Demakovsky L, Tesla B, Goodfellow FT, Stice SL, Murdock CC, Brindley MA Willard KA, Demakovsky L, Tesla B, Goodfellow FT, Stice SL, Murdock CC, Brindley MA. Zika virus exhibits lineage-specific phenotypes in cell culture, in Aedes aegypti mosquitoes, and in an embryo model. Viruses 2017;9(12):E383 (19 pp.). R835551 (Final)
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Journal Article Determination of chlorpyrifos and its metabolites in cells and culture media by liquid chromatography-electrospray ionization tandem mass spectrometry. None Yang X, Wu X, Brown KA, Le T, Stice SL, Bartlett MG Yang X, Wu X, Brown KA, Le T, Stice SL, Bartlett MG. Determination of chlorpyrifos and its metabolites in cells and culture media by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Chromatography B 2017;1063:112-117. EPD15002 (Final)
R835551 (Final)
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Presentation Comparison of human neural progenitor and differentiated human neuronal cells for in vitro tests of neurotoxicity. None Amosu M, Wallace S, Majumder A, Bian X, Lu K, Stice S, Smith MA Amosu M, Wallace S, Majumder A, Bian X, Lu K, Stice S, Smith MA. Comparison of human neural progenitor and differentiated human neuronal cells for in vitro tests of neurotoxicity. Presented at the 55th Annual Meeting of the Teratology Society, Montreal, Quebec, Canada, June 27-July 1, 2015. R835551 (2015)
R835551 (Final)
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Presentation Human stem cell derived neuron and astrocyte co-cultures in a developmental neurotoxicity screening assay. None Anirban M, Xian W, Stice S Anirban M, Xian W, Stice S. Human stem cell derived neuron and astrocyte co-cultures in a developmental neurotoxicity screening assay. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. R835551 (2014)
R835551 (Final)
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Presentation In vitro and in vivo characterization and functional analysis of neural network ontogeny with MR imaging and electrophysiology. None Goodfellow FT, Simchick G, Zhao Q, Stice SL Goodfellow FT, Simchick G, Zhao Q, Stice SL. In vitro and in vivo characterization and functional analysis of neural network ontogeny with MR imaging and electrophysiology. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2016. R835551 (2016)
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Presentation Zika virus induced mortality and microcephaly in chicken embryos. None Goodfellow FT, Tesla B, Simchick G, Hodge T, Zhao Q, Brindley MA, Stice SL Goodfellow FT, Tesla B, Simchick G, Hodge T, Zhao Q, Brindley MA, Stice SL. Zika virus induced mortality and microcephaly in chicken embryos. Presented at the Southeastern Society of Toxicology Annual Meeting, Athens, GA. October 6-7, 2016. R835551 (2016)
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Presentation Zika virus induced mortality and microcephaly in chicken embryos. None Goodfellow FT, Tesla B, Simchick G, Hodge T, Zhao Q, Brindley MA, Stice SL Goodfellow FT, Tesla B, Simchick G, Hodge T, Zhao Q, Brindley MA, Stice SL. Zika virus induced mortality and microcephaly in chicken embryos. Presented at the Southeastern Translational Education and Research Conference, Athens, GA. September 22-23, 2016. R835551 (2016)
R835551 (Final)
not available
Presentation Steps towards tracking human neural progenitor stem cells with novel contrast agents. None Goodfellow F, Ming Q, Wu X, Jordan E, Zhao Q, Stice S Goodfellow F, Ming Q, Wu X, Jordan E, Zhao Q, Stice S. Steps towards tracking human neural progenitor stem cells with novel contrast agents. Presented at the Regenerative Engineering and Medicine Fall 2014 Meeting, Athens, GA, August 12, 2014. R835551 (2014)
R835551 (Final)
not available
Presentation Steps towards tracking human neural progenitor stem cells with novel contrast agents. None Goodfellow F, Ming Q, Wu X, Jordan E, Zhao Q, Stice S Goodfellow F, Ming Q, Wu X, Jordan E, Zhao Q, Stice S. Steps towards tracking human neural progenitor stem cells with novel contrast agents. Presented at the SESOT Fall 2014 Meeting, Athens, GA, October 23-24, 2014. R835551 (2014)
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Presentation Comparative analysis of neural network ontogeny with microelectrode arrays. None Goodfellow F, Daniel T, Stice S Goodfellow F, Daniel T, Stice S. Comparative analysis of neural network ontogeny with microelectrode arrays. Presented at the 2015 World Stem Cell Summit, Atlanta, GA, December 10-12, 2015 (Abstract No. 139361). R835551 (2015)
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Presentation MR imaging of human neural progenitor stem cells: an in vivo longitudinal model. None Goodfellow F, Ming Q, Wu X, Zhao Q, Stice S Goodfellow F, Ming Q, Wu X, Zhao Q, Stice S. MR imaging of human neural progenitor stem cells: an in vivo longitudinal model. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. R835551 (2015)
R835551 (Final)
not available
Presentation In vitro intra-and extra-cellular metabolomic response of neural progenitor cells exposed to bisphenol-A. None Hotop K, Wu X, Stice S, Smith MA Hotop K, Wu X, Stice S, Smith MA. In vitro intra-and extra-cellular metabolomic response of neural progenitor cells exposed to bisphenol-A. Presented at FutureTox II: In Vitro Data and In Silico Models for Predictive Toxicology, Chapel Hill, NC, Jaunary 16-17, 2014. R835551 (2014)
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Presentation Live cell based assay using GFP+ human stem cell derived neurons. None Le J, Chilton J, Majumder A, Wu X, Stice S Le J, Chilton J, Majumder A, Wu X, Stice S. Live cell based assay using GFP+ human stem cell derived neurons. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. R835551 (2014)
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Presentation In-vitro human developmental neurotoxicity screening using multiple cell types. None Majumder A, Wu X, Wallace S, Le J, Stice SL Majumder A, Wu X, Wallace S, Le J, Stice SL. In-vitro human developmental neurotoxicity screening using multiple cell types. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2015. R835551 (2015)
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Presentation Determining developmental neurotoxicity of pesticides utilizing metabolomic profile from neural progenitor cells. None Mckenzie M, Amosu M, Wu X, Wallace S, Henderson M, Bian X, Lu K, Stice SL, Smith MA Mckenzie M, Amosu M, Wu X, Wallace S, Henderson M, Bian X, Lu K, Stice SL, Smith MA. Determining developmental neurotoxicity of pesticides utilizing metabolomic profile from neural progenitor cells. Presented at the 56th Annual Teratology Society Meeting, San Antonio, TX, June 24-29, 2016. R835551 (2016)
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Presentation Non-invasive monitoring of chick embryo brain development using 7T magnetic resonance imaging system. None Meng Q, Goodfellow F, Stice S, Zhao Q Meng Q, Goodfellow F, Stice S, Zhao Q. Non-invasive monitoring of chick embryo brain development using 7T magnetic resonance imaging system. Presented at the SEC MRI/fMRI Collaborative Mini-Conference, University of Georgia, Athens, GA, February 2014. R835551 (2014)
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Presentation Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. None Wu X, Jordan ET, Chilton JM, O'Donnell J, Stice SL Wu X, Jordan ET, Chilton JM, O'Donnell J, Stice SL. Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. Presented at the Interdisciplinary Toxicology Program Annual Retreat, University of Georgia, Athens, GA, April 10, 2014. R835551 (2014)
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Presentation Toxicants differentially effect human neuron maturation, outgrowth and metabolome. None Wu X, Lu K, Jordan ET, Smith MA, Majumder A, Wallace S, Stice SL Wu X, Lu K, Jordan ET, Smith MA, Majumder A, Wallace S, Stice SL. Toxicants differentially effect human neuron maturation, outgrowth and metabolome. Presented at the Regenerative Engineering and Medicine Fall 2014 Meeting, Athens, GA, August 12, 2014. R835551 (2014)
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Presentation Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. None Wu X, Jordan ET, Chilton JM, O'Donnell J, Stice SL Wu X, Jordan ET, Chilton JM, O'Donnell J, Stice SL. Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. R835551 (2014)
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Presentation Toxicants differentially effect human neuron maturation, outgrowth and metabolome. None Wu X, Lu K, Jordan ET, Smith MA, Majumder A, Wallace S, Stice SL Wu X, Lu K, Jordan ET, Smith MA, Majumder A, Wallace S, Stice SL. Toxicants differentially effect human neuron maturation, outgrowth and metabolome. Presented at the Fourth International Conference on Alternatives for Developmental Neurotoxicity Testing (DNT), Philadelphia, PA, May 12-14, 2014. R835551 (2014)
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Presentation Bisphenol-A effects on in vitro human neural development was window of susceptibility dependent. None Wu X, Majumder A, Stice SL Wu X, Majumder A, Stice SL. Bisphenol-A effects on in vitro human neural development was window of susceptibility dependent. Presented at the Interdisciplinary Toxicology Program Annual Retreat, University of Georgia, Athens, GA, April 15, 2015. R835551 (2015)
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Presentation Human pluripotent stem cell derived astrocytes metabolize chlorpyrifos through cytochrome P450 and protect neuron neurite outgrowth inhibition. None Wu X, Majumder A, Stice SL Wu X, Majumder A, Stice SL. Human pluripotent stem cell derived astrocytes metabolize chlorpyrifos through cytochrome P450 and protect neuron neurite outgrowth inhibition. Presented at the 2015 World Stem Cell Summit, Atlanta, GA, December 10-12, 2015. R835551 (2015)
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Presentation Bisphenol-A effects on in vitro human neural development was window of susceptibility dependent. None Wu X, Majumder A, Stice SL Wu X, Majumder A, Stice SL. Bisphenol-A effects on in vitro human neural development was window of susceptibility dependent. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2015. R835551 (2015)
not available
Presentation Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. None Xian W, Jordan ET, Chilton JM, O'Donnell J, Stice SL Xian W, Jordan ET, Chilton JM, O'Donnell J, Stice SL. Quantification of neuron maturation and neurite outgrowth in vitro using human neural progenitor cells. Presented at FutureTox II: In Vitro Data and In Silico Models for Predictive Toxicology, Chapel Hill, NC, January 16-17, 2014. R835551 (2014)
not available
Presentation GFP plus human stem cell-derived neurons amenable to high-content and high-throughput assays. None Yeshi T, Majumder A, Crawford J, Stice SL Yeshi T, Majumder A, Crawford J, Stice S. Chengelis C. GFP plus human stem cell-derived neurons amenable to high-content and high-throughput assays. Poster presented at the American College of Toxicology 36th Annual Meeting, Summerlin, NV, November 8-11, 2015. R835551 (2016)
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