Grantee Research Project Results
Journal Publications Details for Grant Number R833772
Safety/Toxicity Assessment of Ceria (A Model Engineered NP) to the Brain
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | The neurotoxic potential of engineered nanomaterials | NEUROTOXICOLOGY | Boyes W, Chen R, Chen C, Yokel R | Boyes W, Chen R, Chen C, Yokel R. The neurotoxic potential of engineered nanomaterials. NEUROTOXICOLOGY 2012;33(4):902-910 |
R833772 (2009) |
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| Journal Article | Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics | INTERNATIONAL JOURNAL OF NANOMEDICINE | Carlander U, Moto T, Desalegn A, Yokel R, Johanson G | Carlander U, Moto T, Desalegn A, Yokel R, Johanson G. Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics. INTERNATIONAL JOURNAL OF NANOMEDICINE 2018;13:2631-2646 |
R833772 (2009) |
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| Journal Article | Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters | NANOMEDICINE | Dan M, Wu P, Grulke E, Graham U, Unrine J, Yokel R | Dan M, Wu P, Grulke E, Graham U, Unrine J, Yokel R. Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters. NANOMEDICINE 2011;7(1):95-110 |
R833772 (2009) |
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| Journal Article | Inâ Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress | CHEMPLUSCHEM | Graham U, Tseng M, Jasinski J, Yokel R, Unrine J, Davis B, Dozier A, Hardas S, Sultana R, Grulke E, Allan D | Graham U, Tseng M, Jasinski J, Yokel R, Unrine J, Davis B, Dozier A, Hardas S, Sultana R, Grulke E, Allan D. Inâ Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress. CHEMPLUSCHEM 2014;79(8):1083-1088 |
R833772 (2009) |
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| Journal Article | Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing | TOXILOGIC PATHOLOGY | Graham U, Yokel R, Fernback J, Dozier A, Drummy L, Mahalingam K, Tseng M, Birtch E | Graham U, Yokel R, Fernback J, Dozier A, Drummy L, Mahalingam K, Tseng M, Birtch E. Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing. TOXILOGIC PATHOLOGY 2017;46(1):47-61 |
R833772 (2009) |
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| Journal Article | Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review | CHEMICAL RESEARCH IN TOXICOLOGY | Graham U, Dozier A, Oberdorster G, Yokel R, Molina R, Brain J, Pinto J | Graham U, Dozier A, Oberdorster G, Yokel R, Molina R, Brain J, Pinto J. Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review. CHEMICAL RESEARCH IN TOXICOLOGY 2020;33(5):1145-1162 |
R833772 (2009) |
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| Journal Article | Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria | TOXICOLOGICAL SCIENCES | Hardas S, Butterfield D, Sultana R, Tseng M, Dan M, Florence R, Unrine J, Graham U, Wu P, Grulke E, Yokel R | Hardas S, Butterfield D, Sultana R, Tseng M, Dan M, Florence R, Unrine J, Graham U, Wu P, Grulke E, Yokel R. Brain Distribution and Toxicological Evaluation of a Systemically Delivered Engineered Nanoscale Ceria. TOXICOLOGICAL SCIENCES 2010;116(2):562-576 |
R833772 (2009) |
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| Journal Article | Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure | NEUROTOXICITY | Hardas S, Sultana R, Warrier G, Dan M, Florence R, Wu P, Grulke E, Tseng M, Unrine J, Graham U, Yokel R, Butterfield D | Hardas S, Sultana R, Warrier G, Dan M, Florence R, Wu P, Grulke E, Tseng M, Unrine J, Graham U, Yokel R, Butterfield D. Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure. NEUROTOXICITY 2012;33(5):1147-1155 |
R833772 (2009) |
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| Journal Article | Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity | NANOTOXICOLOGY | Hardas S, Sultana R, Warrier G, Dan M, Wu P, Grulke E, Tsang M, Unrine J, Graham U, Yokel R, Butterfield D | Hardas S, Sultana R, Warrier G, Dan M, Wu P, Grulke E, Tsang M, Unrine J, Graham U, Yokel R, Butterfield D. Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity. NANOTOXICOLOGY 2014;8(1):155-166 |
R833772 (2009) |
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| Journal Article | Phthalate metabolism and kinetics in an in vitro model of testis development. | None | Harris S, Wegner S, Hong SW, Faustman EM | Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R833772 (2009) R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
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| Journal Article | Fractal analysis as a complimentary technique for characterizing nanoparticle size distributions | POWDER TECHNOLOGY | Kanniah V, Wu P, Mandzy N, Grulke E | Kanniah V, Wu P, Mandzy N, Grulke E. Fractal analysis as a complimentary technique for characterizing nanoparticle size distributions. POWDER TECHNOLOGY 2012;226:189-198 |
R833772 (2009) |
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| Journal Article | Biokinetics of nanomaterials: The role of biopersistence | NANOLMPACT | Laux P, Riebeling C, Booth A, Brain J, Brunner J, Cerrillo C, Creutzenberg O, Estrela-Lopis I, Gebel T, Johanson G, Jungnickel H, Kock H, Tentscert J, Tlili A, Schaffer A, Sips A, Yokel R, Luch A | Laux P, Riebeling C, Booth A, Brain J, Brunner J, Cerrillo C, Creutzenberg O, Estrela-Lopis I, Gebel T, Johanson G, Jungnickel H, Kock H, Tentscert J, Tlili A, Schaffer A, Sips A, Yokel R, Luch A. Biokinetics of nanomaterials: The role of biopersistence. NANOLMPACT 2017;6:69-80 |
R833772 (2009) |
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| Journal Article | Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria | TOXICOLOGY AND APPLIED PHARMACOLOGY | Tseng M, Lu X, Duan X, Hardas S, Sultana R, Wu P, Unrine J, Graham U, Butterfield A, Grulke E, Yokel R | Tseng M, Lu X, Duan X, Hardas S, Sultana R, Wu P, Unrine J, Graham U, Butterfield A, Grulke E, Yokel R. Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria. TOXICOLOGY AND APPLIED PHARMACOLOGY 2012;260(2):173-182 |
R833772 (2009) |
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| Journal Article | Influence of surface charge on lysozyme adsorption to ceria nanoparticles | APPLIED SURFACE SCIENCE | Wang B, Wu P, Yokel R, Grulke E | Wang B, Wu P, Yokel R, Grulke E. Influence of surface charge on lysozyme adsorption to ceria nanoparticles. APPLIED SURFACE SCIENCE 2012;258(14):5332-5341 |
R833772 (2009) |
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| Journal Article | Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial. | NANOTOXICOLOGY | Yokel RA, Florence RL, Unrine JM, Tseng MT, Graham UM, Wu P, Grulke EA, Sultana R, Hardas SS, Butterfield DA | Yokel RA, Florence RL, Unrine JM, Tseng MT, Graham UM, Wu P, Grulke EA, Sultana R, Hardas SS, Butterfield DA. Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial. Nanotoxicology 2009;3(3):234-248. |
R833772 (2009) |
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| Journal Article | Engineered nanomaterials: exposures, hazards, and risk prevention | JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY | Yokel R, MacPhail R | Yokel R, MacPhail R. Engineered nanomaterials: exposures, hazards, and risk prevention. JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY 2011;6(7) |
R833772 (2009) |
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| Journal Article | Distribution, Elimination, and Biopersistence to 90 Days of a Systemically Introduced 30 nm Ceria-Engineered Nanomaterial in Rats | TOXILOGICAL SCIENCES | Yokel R, Au T, MacPhail R, Hardas S, Butterfield D, Sultana R, Goodman M, Tseng M, Dan M, Haghnazar H, Unrine J, Graham U, Wu P, Grulke E | Yokel R, Au T, MacPhail R, Hardas S, Butterfield D, Sultana R, Goodman M, Tseng M, Dan M, Haghnazar H, Unrine J, Graham U, Wu P, Grulke E. Distribution, Elimination, and Biopersistence to 90 Days of a Systemically Introduced 30 nm Ceria-Engineered Nanomaterial in Rats. TOXILOGICAL SCIENCES 2012;127(1):256-268 |
R833772 (2009) |
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| Journal Article | Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence | NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE | Yokel R, Tseng M, Dan M, Unrine J, Graham U, Wu P, Grulke E | Yokel R, Tseng M, Dan M, Unrine J, Graham U, Wu P, Grulke E. Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE 2013;9(3):398-407 |
R833772 (2009) |
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| Journal Article | Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape | ENVIRONMENTAL SCIENCE: NANO | Yokel R, Unrine J, Wu P, Wang B, Grulke E | Yokel R, Unrine J, Wu P, Wang B, Grulke E. Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape. ENVIRONMENTAL SCIENCE: NANO 2014;1:549-560 |
R833772 (2009) |
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| Journal Article | The yin: an adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity | ENVIRONMENTAL SCIENCE: NANO | Yokel R, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee F | Yokel R, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee F. The yin: an adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity. ENVIRONMENTAL SCIENCE: NANO 2014;1(5):406-428 |
R833772 (2009) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.