Grantee Research Project Results
Journal Publications Details for Grant Number CR830686
Species-Specific Xenobiotic Metabolism Mediated by the Steroid and Xenobiotic Receptor SXR
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. | MOLECULAR ENDOCRINOLOGY | Grun F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, Gardiner DM, Kanno J, Iguchi T, Blumberg B | Grun F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, Gardiner DM, Kanno J, Iguchi T, Blumberg B. Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Molecular Endocrinology 2006;20(9):2141-2155. |
CR830686 (2006) |
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| Journal Article | Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. | ENDOCRINOLOGY | Grun F, Blumberg B | Grun F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 2006;147(6):S50-S55. |
CR830686 (2006) |
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| Journal Article | Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations. | AQUATIC TOXICOLOGY | Gunderson MP, Kohno S, Blumberg B, Iguchi T, Guillette Jr LJ | Gunderson MP, Kohno S, Blumberg B, Iguchi T, Guillette Jr LJ. Up-regulation of the alligator CYP3A77 gene by toxaphene and dexamethasone and its short term effect on plasma testosterone concentrations. Aquatic Toxicology 2006;78(3):272-283. |
CR830686 (2006) |
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| Journal Article | Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). | ENVIRONMENTAL HEALTH PERSPECTIVES | Tabb MM, Kholodovych V, Grün F, Zhou C, Welsh WJ, Blumberg B | Tabb MM, Kholodovych V, Grün F, Zhou C, Welsh WJ, Blumberg B. Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). Environmental Health Perspectives 2004;112(2):163-169. |
CR830686 (2003) CR830686 (2006) R826133 (Final) |
not available |
| Journal Article | New modes of action for endocrine-disrupting chemicals. | MOLECULAR ENDOCRINOLOGY | Tabb MM, Blumberg B | Tabb MM, Blumberg B. New modes of action for endocrine-disrupting chemicals. Molecular Endocrinology 2006;20(3):475-482. |
CR830686 (2006) |
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| Journal Article | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | DRUG METABOLISM AND DISPOSITION | Zhou C, Tabb MM, Sadatrafiei A, Grün F, Blumberg B | Zhou C, Tabb MM, Sadatrafiei A, Grün F, Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metabolism and Disposition 2004;32(10):1075-1082. |
CR830686 (2004) CR830686 (2006) |
not available |
| Journal Article | Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation. | THE JOURNAL OF CLINICAL INVESTIGATION | Zhou C, Tabb MM, Nelson EL, Grun F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B | Zhou C, Tabb MM, Nelson EL, Grun F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B. Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation. The Journal of Clinical Investigation 2006b;116(8):2280-2289. |
CR830686 (2006) |
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| Journal Article | Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. | THE JOURNAL OF CLINICAL INVESTIGATION | Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE | Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. The Journal of Clinical Investigation 2006a;116(6):1703-1712. |
CR830686 (2006) |
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