Grantee Research Project Results

Species-Specific Xenobiotic Metabolism Mediated by the Steroid and Xenobiotic Receptor SXR

EPA Grant Number: CR830686
Title: Species-Specific Xenobiotic Metabolism Mediated by the Steroid and Xenobiotic Receptor SXR
Investigators: Blumberg, Bruce
Institution: University of California - Irvine
EPA Project Officer: Hahn, Intaek
Project Period: January 1, 2003 through December 31, 2005 (Extended to December 31, 2007)
Project Amount: $949,986
RFA: Issues in Human Health Risk Assessment (2001) RFA Text | Recipients Lists
Research Category: Human Health

Objective:

The overall aim of this research project is to aid in providing a molecular basis for understanding the commonalities and differences in how humans and model animals respond to chemical exposure. We hypothesize that activation of the nuclear receptor steroid and xenobiotic receptor/pregnane X receptor (SXR/PXR) and consequent effects on metabolism is the mechanism underlying the differential susceptibility of humans and laboratory animals to environmental chemicals. The specific objectives of this research project are to: (1) characterize the commonalities and differences in the response of human and rodent SXR/PXR; (2) identify functional differences in the activation and/or regulation SXR/PXR among humans and between commonly used strains of laboratory mice; (3) determine whether the compounds are metabolized in vivo; and (4) identify target genes regulated by SXR/PXR as a response to environmental chemical exposure.

Publications and Presentations:

Publications have been submitted on this project: View all 39 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 8 journal articles for this project

Supplemental Keywords:

xenobiotic, species-specific response, pollution, pesticide,, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Risk Assessments, Environmental Chemistry, Biochemistry, Risk Assessment, xenobiotics, human exposure, animal model, chemical exposure, steroids, human health risk, analysis of chemical exposure

Progress and Final Reports:

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.