Grantee Research Project Results
Journal Publications Details for Grant Number R839505
Multiplexed human BrainSphere Developmental Neurotoxicity Test for Six Key Events of Neural Development
RFA:
Advancing Actionable Alternatives to Vertebrate Animal Testing for Chemical Safety Assessment (2018)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | Gene–Environment Interactions in Developmental Neurotoxicity:a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. | ENVIRONMENTAL HEALTH PERSPECTIVES | Modafferi S, Zhong X, Kleensang A, Murata Y, Fagiani F, Pamies D, Hogberg HT, Calabrese V, Lachman H, Hartung T, Smirnova L | Modafferi S, Zhong X, Kleensang A, Murata Y, Fagiani F, Pamies D, Hogberg HT, Calabrese V, Lachman H, Hartung T, Smirnova L. Gene–Environment Interactions in Developmental Neurotoxicity:a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. Environmental Health Perspectives 2021;129(7):077001. |
R839505 (2021) |
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| Journal Article | Human IPSC-Derived Model to Study Myelin Disruption. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | Chesnut M, Paschoud H, Repoind C, Smirnova L, Hartung T, Zurich MG, Hogberg HT, Pamies D | Chesnut M, Paschoud H, Repoind C, Smirnova L, Hartung T, Zurich MG, Hogberg HT, Pamies D. Human IPSC-Derived Model to Study Myelin Disruption. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021;22(17):9473. |
R839505 (2020) |
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| Journal Article | Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells. | REPRODUCTIVE TOXICOLOGY | Pistollato F, Bal-Price A, Coecke S, Parvatam S, Pamies D, Czysz K, Hao J, Kee K, Teo AK, Niu S, Wilmes A | Pistollato F, Bal-Price A, Coecke S, Parvatam S, Pamies D, Czysz K, Hao J, Kee K, Teo AK, Niu S, Wilmes A. Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells. Reproductive Toxicology 2022;112:36-50. |
R839505 (2022) |
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| Journal Article | Shell microelectrode arrays (MEAs) for brain organoids. | SCIENCE ADVANCES | Huang Q, Tang B, Romero JC, Yang Y, Elsayed SK, Pahapale G, Lee TJ, Morales Pantoja IE, Han F, Berlinicke C, Xiang T | Huang Q, Tang B, Romero JC, Yang Y, Elsayed SK, Pahapale G, Lee TJ, Morales Pantoja IE, Han F, Berlinicke C, Xiang T. Shell microelectrode arrays (MEAs) for brain organoids. Science advances 2022;8(33):eabq5031. |
R839505 (2022) |
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| Journal Article | The future of 3D brain cultures in developmental neurotoxicity testing. | FRONTIERS IN TOXICOLOGY | Hogberg HT, Smirnova L | Hogberg HT, Smirnova L. The future of 3D brain cultures in developmental neurotoxicity testing. Frontiers in Toxicology 2022;4:808620. |
R839505 (2022) |
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| Journal Article | Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system. | FRONTIERS IN CELLULAR NEUROSCIENCE | Romero JC, Berlinicke C, Chow S, Duan Y, Wang Y, Chamling X, Smirnova L | Romero JC, Berlinicke C, Chow S, Duan Y, Wang Y, Chamling X, Smirnova L. Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system. Frontiers in Cellular Neuroscience 2023;16:1094291. |
R839505 (2023) |
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| Journal Article | A Novel Approach to Increase Glial Cell Populations in Brain Microphysiological Systems. | ADVANCED BIOLOGY | Morales Pantoja IE, Ding L, Leite PE, Marques SA, Romero JC, Alam El Din DM, Zack DJ, Chamling X, Smirnova L | Morales Pantoja IE, Ding L, Leite PE, Marques SA, Romero JC, Alam El Din DM, Zack DJ, Chamling X, Smirnova L. A Novel Approach to Increase Glial Cell Populations in Brain Microphysiological Systems. Advanced Biology 2023:2300198. |
R839505 (2023) |
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| Journal Article | Organoid intelligence (OI):the new frontier in biocomputing and intelligence-in-a-dish. | FRONTIERS IN SCIENCE | Smirnova L, Caffo BS, Gracias DH, Huang Q, Morales Pantoja IE, Tang B, Zack DJ, Berlinicke CA, Boyd JL, Harris TD, Johnson EC | Smirnova L, Caffo BS, Gracias DH, Huang Q, Morales Pantoja IE, Tang B, Zack DJ, Berlinicke CA, Boyd JL, Harris TD, Johnson EC. Organoid intelligence (OI):the new frontier in biocomputing and intelligence-in-a-dish. Frontiers in Science 2023:0. |
R839505 (2023) |
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| Journal Article | Progress in human stem cell-derived models for developmental and reproductive toxicology studies. | REPRODUCTIVE TOXICOLOGY | Smirnova L, Stacey GN | Smirnova L, Stacey GN. Progress in human stem cell-derived models for developmental and reproductive toxicology studies. Reproductive toxicology 2022:S0890-6238. |
R839505 (2022) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.