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Grantee Research Project Results

Journal Publications Details for Grant Number R827180

PAH Metal Mixtures-Human in Vitro Mutagenicity Studies

RFA: Chemical Mixtures in Environmental Health (1998)

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Journal Article (8)
Reference Type Citation Progress Report Year Document Sources
Journal Article Bessette EE, Fasco MJ, Pentecost BT, Kaminsky LS. Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. Drug Metabolism and Disposition 2005;33(3):312-320. R827180 (Final)
  • Abstract from PubMed
  • Full-text: Drug Metabolism & Disposition
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  • Abstract: Drug Metabolism & Disposition
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  • Other: Drug Metabolism & Disposition
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Journal Article Ding XX, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Review of Pharmacology and Toxicology 2003;43(1):149-173. R827180 (2003)
not available
Journal Article Liu N, Zhang Q-Y, Vakharia D, Dunbar D, Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? Archives of Biochemistry and Biophysics 2001;389(1):130-134. R827180 (2001)
R827180 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct PDF
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  • Abstract: Science Direct
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Journal Article Spink DC, Wu SJ, Spink BC, Hussain MM, Vakharia DD, Pentecost BT, Kaminsky LS. Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Toxicology and Applied Pharmacology 2008;226(3):213-224. R827180 (Final)
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  • Abstract from PubMed
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  • Full-text: Science Direct
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  • Abstract: Science Direct
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  • Other: Science Direct PDF
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Journal Article Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS. Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metabolism and Disposition 2002;30(3):262-269. R827180 (2001)
R827180 (2002)
R827180 (Final)
  • Abstract from PubMed
  • Full-text: Drug Metabolism & Disposition
    Exit
  • Abstract: Drug Metabolism & Disposition
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  • Other: Drug Metabolism & Disposition PDF
    Exit
Journal Article Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocytes cultures. Toxicology and Applied Pharmacology 2001;170(2):93-103. R827180 (2000)
R827180 (2001)
R827180 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct PDF
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  • Abstract: Science Direct
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Journal Article Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Drug Metabolism and Disposition 2001;29(7):999-1006. R827180 (2000)
R827180 (2001)
R827180 (Final)
  • Abstract from PubMed
  • Full-text: Drug Metabolism & Disposition
    Exit
  • Abstract: Drug Metabolism & Disposition
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  • Other: Drug Metabolism & Disposition PDF
    Exit
Journal Article Wu SJ, Spink DC, Spink BC, Kaminsky LS. Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Analytical Biochemistry 2003;312(2):162-166. R827180 (2002)
R827180 (2003)
R827180 (Final)
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  • Abstract: Science Direct
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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