Grantee Research Project Results
Publications Details for Grant Number R827180
PAH Metal Mixtures-Human in Vitro Mutagenicity Studies
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Bessette E, Fasco MJ, Pentecost B, Kaminsky L. Mechanisms of arsenite's effect on polycyclic aromatic hydrocarbon (PAH) induction of human cytochrome P4501A1. Drug Metabolism Reviews 2003;35:133. |
R827180 (2003) R827180 (Final) |
not available |
| Abstract | Kaminsky L, Vakharia D, Zhang Q-Y, Liu N. Induction of CYP1A1/1A2 in human hepatocytes: effects of toxic metals. Drug Metabolism Reviews 2000;32:242. |
R827180 (2000) |
not available |
| Abstract | Kaminsky L, Vakharia D. PAH/Metal mixtures: effect on PAH induction of CYP1A in cultured human hepatocytes. The Toxicologist 2000;54:97. |
R827180 (2000) |
not available |
| Abstract | Kaminsky LS. Mechanisms of environmental metal modulation of PAH induction of human CYP1 in vitro. Drug Metabolism Reviews 2001;33:144. |
R827180 (2001) R827180 (Final) |
not available |
| Abstract | Spink D, Katz B, Hussain M, Kaminsky L. Transient induction of CYP1A1/CYP1B1-catalyzed estrogen metabolism in T-47D cells by benzo[a]pyrene is diminished by arsenite. The Toxicologist 2000;54:100. |
R827180 (2000) R827180 (Final) |
not available |
| Abstract | Vakharia D, Ning L, Kaminsky L. PAH/Metal mixtures: effect on PAH induction of human CYP1A1 in HepG2 cells. The Toxicologist 2000;54:98. |
R827180 (2000) R827180 (Final) |
not available |
| Abstract | Vakharia D, Kaminsky LS. Effect of binary, ternary, and quaternary mixtures of PAHs on CYP1A1 induction in human HepG2 cells. The Toxicologist 2001;60:402. |
R827180 (2000) R827180 (2001) R827180 (Final) |
not available |
| Abstract | Zhang Q-Y, Wu Susan, Guengerich PF, and Kaminsky LS. The effects of metal on PAH genotoxicity. Drug Metabolism Reviews 2003;35(S2):1-230. |
R827180 (Final) |
not available |
| Journal Article | Bessette EE, Fasco MJ, Pentecost BT, Kaminsky LS. Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. Drug Metabolism and Disposition 2005;33(3):312-320. |
R827180 (Final) |
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| Journal Article | Ding XX, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Review of Pharmacology and Toxicology 2003;43(1):149-173. |
R827180 (2003) |
not available |
| Journal Article | Liu N, Zhang Q-Y, Vakharia D, Dunbar D, Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? Archives of Biochemistry and Biophysics 2001;389(1):130-134. |
R827180 (2001) R827180 (Final) |
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| Journal Article | Spink DC, Wu SJ, Spink BC, Hussain MM, Vakharia DD, Pentecost BT, Kaminsky LS. Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Toxicology and Applied Pharmacology 2008;226(3):213-224. |
R827180 (Final) |
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| Journal Article | Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS. Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metabolism and Disposition 2002;30(3):262-269. |
R827180 (2001) R827180 (2002) R827180 (Final) |
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| Journal Article | Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocytes cultures. Toxicology and Applied Pharmacology 2001;170(2):93-103. |
R827180 (2000) R827180 (2001) R827180 (Final) |
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| Journal Article | Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Drug Metabolism and Disposition 2001;29(7):999-1006. |
R827180 (2000) R827180 (2001) R827180 (Final) |
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| Journal Article | Wu SJ, Spink DC, Spink BC, Kaminsky LS. Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Analytical Biochemistry 2003;312(2):162-166. |
R827180 (2002) R827180 (2003) R827180 (Final) |
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| Presentation | Bessette EEB, Fasco MJ, Pentecost B, Kaminsky LS. Mechanisms of arsenite’s effect on polycyclic aromatic hydrocarbon (PAH) induction of human cytochrome P4501A1. Presented at the 12th North American International Society for the Study of Xenobiotics Meeting, Providence, RI, October 12-16, 2003. |
R827180 (Final) |
not available |
| Presentation | Kaminsky LS, Wu SJ, Spink BC, Hussain MM, Pentecost BT, Spink DC. Metabolites of benzo[k]fluoranthene (BKF) are potent CYP1 inducers in T-47D human breast cancer cells. To be presented at the Federation of American Societies for Experimental Biology, San Diego, CA, April 2-6, 2005. |
R827180 (Final) |
not available |
| Presentation | Kaminsky LS. Mechanisms of environmental metal modulation of PAH induction of human CYP1 in vitro. Presented at the 6th International ISSX Meeting, Munich, October 2001. |
R827180 (2001) R827180 (Final) |
not available |
| Presentation | Kaminsky L, Vakharia D. PAH/Metal mixtures: effect on PAH induction of CYP1A in cultured human hepatocytes. Presented at the Society of Toxicology Meeting, Philadelphia, PA, 2000. |
R827180 (1999) R827180 (Final) |
not available |
| Presentation | Spink D, Wu SJ, Spink BC, Katz BH, Fasco MJ, Kaminsky LS. Effects of benzo[a]pyrene and arsenite on CYP1A1 and CYP1B1 mRNA levels in T-47D human breast cancer cells: determination by a branched DNA assay. Presented at the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R827180 (Final) |
not available |
| Presentation | Spink D, Katz B, Hussain M, Kaminsky L. Transient induction of CYP1A1/CYP1B1-catalyzed estrogen metabolism in T-47D cells by benzo[a]pyrene is diminished by arsenite. Presented to the Society of Toxicology Meeting, Philadelphia, PA, 2000. |
R827180 (1999) R827180 (2000) R827180 (Final) |
not available |
| Presentation | Vakharia D, Kaminsky LS. Effect of binary, ternary, and quaternary mixtures of PAHs on CYP1A1 induction in human HepG2 cells. Presented at the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R827180 (Final) |
not available |
| Presentation | Vakharia D, Ning L, Kaminsky L. PAH/Metal mixtures: effect on PAH induction of human CYP1A1 in HepG2 cells. Presented at the Society of Toxicology Meeting, Philadelphia, PA, 2000. |
R827180 (1999) R827180 (2000) |
not available |
| Presentation | Zhang Q-Y, Wu Susan, Guengerich PF, and Kaminsky LS. The effects of metal on PAH genotoxicity. Presented at the 12th North American International Society for the Study of Xenobiotics Meeting, Providence, RI, October 12-16, 2003. |
R827180 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.