Grantee Research Project Results
Journal Publications Details for Grant Number R827180
PAH Metal Mixtures-Human in Vitro Mutagenicity Studies
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells | DRUG METABOLISM AND DISPOSITION | Bessette EE, Fasco MJ, Pentecost BT, Kaminsky LS | Bessette EE, Fasco MJ, Pentecost BT, Kaminsky LS. Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. Drug Metabolism and Disposition 2005;33(3):312-320. |
R827180 (Final) |
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Journal Article | Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. | ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | Ding XX, Kaminsky LS | Ding XX, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Review of Pharmacology and Toxicology 2003;43(1):149-173. |
R827180 (2003) |
not available |
Journal Article | Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | Liu N, Zhang Q-Y, Vakharia D, Dunbar D, Kaminsky LS | Liu N, Zhang Q-Y, Vakharia D, Dunbar D, Kaminsky LS. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? Archives of Biochemistry and Biophysics 2001;389(1):130-134. |
R827180 (2001) R827180 (Final) |
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Journal Article | Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Spink DC, Wu SJ, Spink BC, Hussain MM, Vakharia DD, Pentecost BT, Kaminsky LS | Spink DC, Wu SJ, Spink BC, Hussain MM, Vakharia DD, Pentecost BT, Kaminsky LS. Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Toxicology and Applied Pharmacology 2008;226(3):213-224. |
R827180 (Final) |
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Journal Article | Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. | DRUG METABOLISM AND DISPOSITION | Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS | Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS. Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Drug Metabolism and Disposition 2002;30(3):262-269. |
R827180 (2001) R827180 (2002) R827180 (Final) |
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Journal Article | Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocytes cultures. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS | Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocytes cultures. Toxicology and Applied Pharmacology 2001;170(2):93-103. |
R827180 (2000) R827180 (2001) R827180 (Final) |
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Journal Article | Polycyclic aromatic hydrocarbon/metal mixtures: Effect on PAH induction of CYP1A1 in human HEPG2 cells. | DRUG METABOLISM AND DISPOSITION | Vakharia D, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS | Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang Q-Y, Kaminsky LS. Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Drug Metabolism and Disposition 2001;29(7):999-1006. |
R827180 (2000) R827180 (2001) R827180 (Final) |
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Journal Article | Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. | ANALYTICAL BIOCHEMISTRY | Wu SJ, Spink DC, Spink BC, Kaminsky LS | Wu SJ, Spink DC, Spink BC, Kaminsky LS. Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Analytical Biochemistry 2003;312(2):162-166. |
R827180 (2002) R827180 (2003) R827180 (Final) |
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