Grantee Research Project Results
Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) Center for Environmental Health Disparities Research
EPA Grant Number: R836158Center: Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) Center for Environmental Health Disparities Research
Center Director: Van Doren Breton, Carrie
Title: Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) Center for Environmental Health Disparities Research
Investigators: Van Doren Breton, Carrie , Bastain, Theresa Frilund , Gilliland, Frank D. , Hricko, Andrea M. , Cockburn, Myles G , Dunton, Genevieve Frilund
Current Investigators: Van Doren Breton, Carrie , Gilliland, Frank D. , Hricko, Andrea M. , Bastain, Theresa Frilund , Cockburn, Myles G , Dunton, Genevieve Frilund
Institution: University of Southern California
Current Institution: University of Southern California
EPA Project Officer: Callan, Richard
Project Period: July 1, 2015 through June 30, 2020 (Extended to June 30, 2021)
Project Amount: $1,500,000
RFA: NIH/EPA Centers of Excellence on Environmental Health Disparities Research (2015) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Eliminating racial and ethnic disparities in obesity is a national priority, especially given the numerous adverse cardio-metabolic consequences. By age 2, Hispanic children are nearly twice as likely to have a weight-for- length value >95th percentile compared to non-Hispanic white children. Rates of pregnancy-related obesity are also disproportionately high among Hispanic women. At the same time, over 19% of the California's Hispanic population resides in one of the 10% most environmentally-burdened communities, while fewer than 3% of the state's white population lives in those communities. These data confirm striking environmental and health disparities affecting Hispanics that are not well understood. To address these underlying disparities, we propose to establish the “Maternal And Developmental Risks from Environmental and Social Stressors (MADRES)” Center for Environmental Health Disparities in a large, prospective pregnancy cohort of lower income, predominantly Hispanic women in Los Angeles. Understanding causes of childhood obesity, excessive gestational weight gain and postpartum weight retention among minority and low-income children and mothers, respectively, is necessary to reduce the disproportionate burden of disease born by these individuals. The proposed MADRES Center will examine whether environmental exposures (including air pollution, metals, water contaminants, and toxic releases), coupled with exposures to psychosocial and built environment stressors, lead to excessive gestational weight gain and postpartum weight retention in women and to perturbed infant growth trajectories and increased childhood obesity risk through altered psychological, behavioral and/or metabolic responses. In order to uncover key mechanistic targets for policy, clinical, and programmatic intervention, we propose cutting-edge technologies of cortisol assessment and abdominal fat quantification, real-time data collection using ecological momentary assessment, state-of- the-art statistical methods, and novel methods for evaluating mitochondrial function. As current treatment strategies often target individuals who are already obese and have met with mixed success in minority populations, alternative strategies aimed at preventing the risk factors driving obesity are urgently needed. The MADRES Center proposes two highly-innovative Research Projects, a strong Community Engagement Core, a Population Core, an Exposure Core, and an Administrative Core with a robust Career Development Program. The MADRES Center brings together clinical, environmental, social and public health scientists and community engagement professionals to enhance a world-class research and outreach program in environmental health disparities. Our collaborative, integrated, multi-disciplinary approach will efficiently address key gaps in the knowledge base needed for timely and effective disease prevention strategies, better transportation and urban design policies, and recommendations for stress-coping strategies and behaviors to reduce infant and lifelong obesity risk and its metabolic consequences.
Journal Articles: 12 Displayed | Download in RIS Format
Other center views: | All 14 publications | 10 publications in selected types | All 10 journal articles |
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Corona K, Chavez T, Stewart K, Toledo-Corral C, Farzan S, Habre R, Grubbs B, Al-Marayati L, Lurvey N, Lerner D, Eckel S, Lagomazino I, Breton C, Bastain T. Adverse childhood experiences and prenatal depression in the maternal and development risks from environmental and social stressors pregnancy cohort. JOURNAL OF OBSTETRICS AND GYNAECOLOGY 2022;Early Access. |
R836158 (Final) |
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Zhang Y, Berhane K, Eckel S, Muchmore P, Molshatzki N, Rappaport E, Linn W, Habre R, Gilliland F. Adverse Effects of Annual Fluctuations in Air Pollution on FeNO in Children:A Longitudinal Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197. |
R836158 (Final) R831861 (Final) |
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Alderete TL, Song AY, Bastain T, Habre R, Toledo-Corral CM, Salam MT, Lurmann F, Gilliland FD, Breton CV. Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatric Obesity 2018:13(6):348-356. |
R836158 (2017) R836158 (2018) R836158 (2019) R836158 (2020) R835441 (2018) |
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Farzan SF, Howe CG, Chavez TA, Hodes TL, Johnston JE, Habre R, Dunton G, Bastain TM, Breton CV. Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles. Journal of exposure science & environmental epidemiology 2020:1-4. |
R836158 (2020) |
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Hernandez-Castro I, Eckel S, Howe C, Niu Z, Kannan K, Robinson M, Foley H, Grubbs B, Al-Marayati L, Lerner D, Lurvey N, Aung M, Habre R, Dunton G, Farzan S, Breton C, Bastain T. Sex-specific effects of prenatal organophosphate ester (OPE) metabolite mixtures and adverse infant birth outcomes in the maternal and developmental risks from environmental and social stressors (MADRES) pregnancy cohort. ENVIRONMENTAL RESEARCH 2023;226(115703) |
R836158 (Final) |
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Hernandez-Castro I, Eckel S, Chen X, Yang T, Vigil M, Foley H, Kannan K, Robinson M, Grubbs B, Lerner D, Lurvey N, Al-Marayati L, Habre R, Dunton G, Farzan S, Aung M, Brexton C, Bastain T. Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort. ENVIRONMENTAL POLLUTION 2024;342(123131) |
R836158 (Final) |
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Maldonado L, Farzan S, Toledo-Corral C, Dunton G, Habre R, Eckel S, Johnson M, Yang T, Grubbs B, Lerner D, Chavez T, Breton C, Bastain T. A Vegetable, Oil, and Fruit Dietary Pattern in Late Pregnancy is Linked to Reduced Risks of Adverse Birth Outcomes in a Predominantly Low-Income Hispanic and Latina Pregnancy Cohort. JOURNAL OF NUTRITION 2022;. |
R836158 (Final) |
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Niu Z, Habre R, Chavez T, Yang T, Grubbs B, Eckel S, Berhane K, Toledo-Corral C, Johnston J, Dunton G. Association Between Ambient Air Pollution and Birth Weight by Maternal Individual- and Neighborhood-Level Stressors. JAMA NETWORK OPEN 2022;5(10) |
R836158 (Final) |
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Peterson A, Habre R, Niu Z, Amin M, Yang T, Eckel S, Farzan S, Lurman F, Pavlovic N, Grubbs B, Walker D, Al-Marayati L, Grant E, Lerner D, Bastain T, Breton C. Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort. NATURE HUMAN BEHAVIOR 2022;21(1):115 |
R836158 (Final) |
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Zhang Y, Chen Z, Berhane K, Urman R, Chatzi V, Breton C, Gilliland F. The Dynamic Relationship Between Asthma and Obesity in Schoolchildren. American Journal of Epidemiology 2020;189(6):583-591. |
R836158 (Final) R826708 (Final) |
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O’Connor SG, Habre R, Bastain TM, Toledo-Corral CM, Gilliland FD, Eckel SP, Cabison J, Naya CH, Farzan SF, Chu D, Chavez TA. Within-subject effects of environmental and social stressors on pre-and post-partum obesity-related biobehavioral responses in low-income Hispanic women:protocol of an intensive longitudinal study. BMC Public Health 2019;19(1):253. |
R836158 (2019) R836158 (2020) |
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Howe CG, Farzan SF, Garcia E, Jursa T, Iyer R, Berhane K, Chavez TA, Hodes TL, Grubbs BH, Funk WE, Smith DR. Arsenic and birth outcomes in a predominately lower income Hispanic pregnancy cohort in Los Angeles. Environmental Research 2020:109294. |
R836158 (2020) |
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Progress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836158C001 Cumulative prenatal and infant environmental exposures and early childhood obesity risk
R836158C002 Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight Outcomes
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
10 journal articles for this center