Grantee Research Project Results
Consortium for Manufactured Nanomaterial Bioavailability & Environmental Exposure
EPA Grant Number: R834575Title: Consortium for Manufactured Nanomaterial Bioavailability & Environmental Exposure
Investigators: Colvin, Vicki L. , Klaine, Stephen J. , Tyler, Charles , Valsami-Jones, Eugenia , Lead, Jamie , Chipman, Kevin , Viant, Mark , Luoma, Sam , Fernandes, Teresa , Stone, Vicki
Current Investigators: Lead, Jamie , Alvarez, Pedro J. , Colvin, Vicki L. , Klaine, Stephen J. , Luoma, Sam , Stone, Vicki , Tyler, Charles , Valsami-Jones, Eugenia , Chipman, Kevin , Viant, Mark , Fernandes, Teresa
Institution: Rice University , University of California - Davis , Natural History Museum (London) , University of Birmingham , Edinburgh Napier University , Clemson University , University of Exeter
Current Institution: Rice University , Clemson University , University of California - Davis , University of Exeter , University of Birmingham , Edinburgh Napier University , Natural History Museum (London)
EPA Project Officer: Aja, Hayley
Project Period: August 1, 2010 through August 1, 2013 (Extended to December 31, 2015)
Project Amount: $2,000,000
RFA: Environmental Behavior, Bioavailability and Effects of Manufactured Nanomaterials - Joint US – UK Research Program (2009) RFA Text | Recipients Lists
Research Category: Chemical Safety for Sustainability
Description:
The nano-BEE consortia will develop and refine, using empirical data, a critical subset of models focused on exposure to nanomaterials (NMs) and their bioavailability in the environment. The objectives of this study are to (a) generate controlled and well-characterized NMs libraries for environmental assessment (b) prove that soft landed gold clusters provide suitable fiducial markers to enable angstrom resolution in aquatic tomography of NMs in environmental media (c) demonstrate that NM environmental modification processes can be classified by the extent of aggregation, dissolution and surface modification and to experimentally and computationally describe the partition of these modified NMs between environmental compartments (d) to develop modified biodynamic models for NM bioavailability that reflect both water and food exposures and (e) to validate biotic ligand models for NM effects on aquatic organisms. An integrated computational and experimental program will examine the environmental chemistry of manufactured NMs using electron microscopy, scattering techniques, and spectroscopy; use traceable NMs to quantify influx and efflux rates in model aquatic species, including in a trophic chain; and employ both conventional measures of toxicological endpoints as well as the latest molecular (‘omics’) methods to quantify biological effects as well as identify new mechanisms for toxicity. Such information will be input into biotic ligand models for NMs classes that output anticipated EC50 and other outcomes given information about NM exposure and local water chemistry. Through its engagement with end-users the consortia will link its predictions of NM body burdens and toxicological outcomes to risk management frameworks useful in regulatory decision-making. The expected results will lead to improved risk management of nanomaterials based on quantitative models for bioavailability.
Publications and Presentations:
Publications have been submitted on this project: View all 37 publications for this projectJournal Articles:
Journal Articles have been submitted on this project: View all 35 journal articles for this projectSupplemental Keywords:
Nanotechnology, nanoscience, bioavailability, emerging contaminants, environmental modeling, manufactured nanoparticles, biotic ligand model, biodynamic model, environmental exposure model;Progress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.