Grantee Research Project Results
2011 Progress Report: The Columbia Center for Children’s Environmental Health
EPA Grant Number: R834509Center: The Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: The Columbia Center for Children’s Environmental Health
Investigators: Perera, Frederica P. , Andrews, Howard F. , Miller, Rachel L. , Whyatt, Robin M. , Garfinkel, Robin S. , Rundle, Andrew , Peterson, Brad , Evans, David , Tang, Deliang , Champagne, Frances , Freyer, Greg , Moore, Holly , Shepard, Peggy , Oberfield, Sharon , Rauh, Virginia
Current Investigators: Perera, Frederica P. , Whyatt, Robin M. , Miller, Rachel L. , Evans, David , Rauh, Virginia , Andrews, Howard F. , Champagne, Frances , Rundle, Andrew , Shepard, Peggy
Institution: Columbia University in the City of New York
Current Institution: Columbia University in the City of New York , Resources for the Future , West Harlem Environmental Action (WE ACT for Environmental Justice) , Columbia University Mailman School of Public Health
EPA Project Officer: Callan, Richard
Project Period: September 24, 2009 through September 23, 2014 (Extended to September 23, 2015)
Project Period Covered by this Report: September 24, 2010 through September 23,2011
Project Amount: $3,953,320
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
R834509C001: Endocrine Disruptors and Obesity among Inner-City Children
Aim 1: To test whether prenatal and early-life exposures to the endocrine disruptors PAH and BPA predict body size growth trajectories and childhood obesity at age 8-10 years. This will be accomplished by following our ongoing birth cohort to age 8-10 years, measuring height and weight at ages 5, 7, 8-10, body composition at age 7, 8-10, and metabolic syndrome components at age 8-10 years. This work takes advantage of a sophisticated geographic information systems based data on the children’s neighborhoods to control for social (e.g. poverty and socio-demographic composition) and physical factors (e.g. play grounds, parks, fast-food) likely to predict childhood obesity. Aim 2: To determine whether differences in the methylation status of key genes involved in adipogenesis (PPARγ2, C/EBPα, C/EBPß, C/EBPδ and DLK1), appetite control (FTO), mediates the association between xenobiotic exposures and childhood obesity outcomes. Methylation of these genes will be measured in cord white blood cell DNA by pyrosequencing.
R834509C002: Endocrine Disrupters, Epigenetic Mechanisms & Neurodevelopment
- Determine whether prenatal exposures to the endocrine disruptors, PAH and BPA, are associated with adverse neurobehavioral outcomes in peri-pubertal children, as measured by diagnostic assessment of child psychopathology and cognitive functioning;
- Determine whether prenatal exposure to PAH or BPA is associated with epigenetic changes in candidate genes is associated with endocrine disruption and immune dysregulation, and whether altered methylation/gene expression in these candidates is associated with the neurobehavioral outcomes;
- Using GIS, determine the extent to which neighborhood-level conditions contribute to neurobehavioral outcomes and/or moderate the individual-level associations between exposure to PAH or BPA and child neurodevelopment.
R834509C003: Molecular/disease consequences of prenatal BPA, PAH exposure across generations
- Examine the consequence of prenatal oral BPA exposure on neurobehavioral, obesity and immune dysfunction in Balb/c mice by determining whether prenatal BPA exposure is associated with abnormal brain cytoarchitecture, impaired social, anxiety-like and cognitive performance, greater adult body weight, body fat composition and organ fat, and immune dysfunction in the adult offspring or grandoffspring. (2) Examine the consequence of prenatal oral BPA exposure for tissue-specific molecular modifications in mice by determining prenatal BPA exposure-induced changes in DNA methylation in genes sensitive to endocrine disruption and immune dysregulation in the brain (hippocampus, hypothalamus, cortex), adipocytes and blood of the prenatally BPA exposed offspring and grandoffspring at gestation day19 and adulthood (PND60). (3) Examine the consequence of prenatal inhaled PAH exposure at current levels determined to exist in New York City’s Northern Manhattan/South Bronx on neurodevelopment and obesity in Balb/c mice by determining whether prenatal PAH exposure is associated with abnormal brain cytoarchitecture, impaired anxiety-like and cognitive performance, greater body weight through weaning to adulthood, body fat composition and organ fat content in adult offspring and grand offspring. (4) Examine the consequence of prenatal inhaled PAH exposure for tissue specific molecular modifications (DNA methylation) in mice of genes sensitive to endocrine disruption and immune dysregulation in the brain, adipocytes and blood of the prenatally exposed offspring and grandoffspring at gestation day19 and PND60.
Adminstrative Core
- Oversee all administrative and financial aspects of the Center; 2) Facilitate scientific interactions between the Center’s research projects and cores, and the External Advisory Committee; 3) Collaborate with the Pediatric Health Specialist and the Community Outreach and Translation Core (COTC) to ensure translation and dissemination of scientific findings; and 4) Facilitate career development of junior faculty-level investigators within the Center.
Data Management, Statistics and Community Modeling Core
- Provide the centralized resource for all data management needs of the CCCEH projects, including database design, implementation and modification; data entry; and data retrieval for statistical analysis;
- Implement procedures to maintain data quality, data security and confidentiality;
- Coordinate and oversee design and implementation of all statistical analyses for testing primary and secondary hypotheses, and provide statistical review of all publications for the research projects;
- Integrate geographic information systems, including acquisition and updating of community-level data, geocoding, mapping, and application of multi-level modeling, as required by the cohort-based Neurodevelopmental and Obesity projects.
Community Outreach and Translation Core
- Engage and expand the Community Advisory and Stakeholder Board;
- Communicate the Center’s research findings through the development of educational materials designed for local residents, community organizations, healthcare providers, and other local stakeholders;
- In collaboration with the Center’s Pediatric Health Specialist, facilitate education of public health and clinical professionals working in low-income communities of color;
- Disseminate the Center’s findings using several communication methods;
- Through our partnership with WE ACT, expand the capacity of low-income communities of color to advocate for improved environmental conditions by using the Center’s scientific findings and related findings by other investigators.
Progress Summary:
R834509C001: Endocrine Disruptors and Obesity among Inner-City Children
Thus far over 95% of the eligible children have participated in the study. Analyses of mothers’ exposures to ambient air polycyclic aromatic hydrocarbons (PAH) and obesity outcomes of their children at age 5 and 7 have been completed and a manuscript has been submitted. We have also completed cross-sectional analysis of predictors and correlates of bisphenyl A (BPA) levels in urine samlpes collected from the mothers during pregnancy and from the children at ages 3, 5 and 7. We have trouble-shot and established the pyrosequencing laboratory methods for measuring methylation status in the six candidate genes and have begun pyrosequencing cord blood DNA for PPAR-Gamma.
R834509C002: Endocrine Disrupters, Epigenetic Mechanisms & Neurodevelopment
We recently found that children in the highest quartile of prenatal PAH exposure, as measured by adducts in umbilical cord blood, had higher symptom scores of anxiety/depression between 3-6 years, attention problems at between 3-6 years and 6-8 years, and with Diagnostic and Statistical Manual of Mental Disorders (DSM) oriented Anxiety Problems at 3-6 years (all p <0.05). These results provide evidence that environmental PAH at levels encountered in NYC air can adversely affect child behavior, especially internalizing problems that could affect school performance. We are also testing the association between BPA and child behavior outcomes in children ages 3-5.
Prenatal and postnatal urine has been sent to CDC to measure BPA and PAH metabolites and we received the results on prenatal and 3-7 year PAH metabolites as well as prenatal and 3 year BPA measures. We have been optimizing our laboratory methods to evaluate associations between prenatal PAH and BPA and gene-specific DNA methylation in 10 genes: NMDAR2b, CCL17, AhR, COX-2, INF-γ, ERα, CEBPα, PDE4D, TH, and THRβ. Thus far, we have optimized conditions for the methylation assay for 8 of 10 genes, and are continuing to work on assays for the remaining two. In addition, we have run the assay for ERα on samples from 400 mothers and 400 newborns. Methylation analyses of the remaining 7 genes are in queue.
R834509C003: Molecular/disease consequences of prenatal BPA, PAH exposure across generations
Analysis of 3 cohorts of mice exposed prenatally to low dose BPA (2ug/kg, 20ug/kg, 200ug/kg) currently is being finalized and includes fetal (gestational Day 18), juvenile (postnatal Day 30) and adult (day 60-90) Balb/c mice. We have established pyrosequencing protocols in the lab to assess DNA methylation levels in sodium bisulfate-treated DNA samples. We have completed primer design for the A, B, and C promotors of the mouse ESR1 (ERα) gene. In addition, we have optimized the experimental exposure of polycyclic aromatic hydrocarbons to pregnant and juvenile mice.
Adminstrative Core
Administrative & Financial Management: Core staff coordinated CCCEH administrative activities and also provided financial management for the cores and projects. Core staff worked with Center investigators to organize a meeting of the External Advisory Board (EAC). The advisory committee meeting for 2011 took place on May 23rd in New York City. Core staff continued to organize and facilitate meetings of the CCCEH Executive Committee, which meets every 6 weeks, to address cross-project scientific and administrative issues. In December 2010, Administrative Core staff, in collaboration with the COTC, developed and published a brochure on Integrated Pest Management (IPM). The CCCEH website was updated regularly with new publications and scientific findings. Administrative Core staff coordinated with COTC in drafting and disseminating e-news blasts and press releases about recent Center findings. Starting in 2011, COTC and Admin Core staff also started a Facebook page. Administrative Core and COTC staff members have continued to work with the Center’s Pediatric Health Specialist to discuss strategies for presenting scientific research findings at Grand Rounds, community health events, local policy forums, and trainings of local leaders on environmental health risks. The Center’s Faculty Development Investigator, Dr. Gina Lovasi, was appointed as an Assistant Professor of Epidemiology at the Mailman School of Public Health in September 2009. She led an analysis of residential mobility in the CCCEH cohort, has guest lectured in Environment Epidemiology and Molecular Epidemiology courses, and co-organized a conference on best practices and new directions in neighborhood research.
Data Management, Statistics and Community Modeling Core
All Columbia Center for Children's Environmental Health (CCCEH) project data are housed in a Scientific Information Retrieval (SIR) database management system that is maintained by the Data Management, Statistics and Community Modeling (DSM) Core. The DSM Core is also the central resource for statistical consultation and data analysis related to the development of manuscripts. Data security is ensured at the level of the server, the user, and the database. All data are fully compliant with Health Information Portability and Accountability Act (HIPAA) regulations. The DSM Core holds a meeting every Thursday at 10:30am. The meeting is open to any project investigator and provides consultation with respect to the development of data requests, statistical analysis, interpretation of findings, and manuscript review. Project 1: Enrollment is underway with 287 of cohort subjects enrolled in Project 1. Fasting blood lipids have been analyzed for 287 subjects. Tanner staging by a clinician has been performed on 276 subjects and food frequency questionnaires have been administered to 268 subjects. James Quinn, GIS expert, has geocoded the 4089 unique current addresses at the time of interview for all CCCEH subjects through age 9 years. Project 2: In consultation with Drs. Rauh and Williams, Lori Hoepner is developing the neurodevelopment assessment component of the database. Project 3: The DSM has devised plans for statistical review and data storage for this project once data become available.
Community Outreach and Translation Core
- CASB Development: CCCEH restructured and continues to expand the CASB to include active members from the community and governmental agencies engaged in advocacy and community awareness of environmental health issues—emphasizing obesity and child development
- Health Education: Core staff produced an informative brochure explaining integrated pest management—a pesticide free method to pest control, printed in Spanish and English.
- Education for Public Health and Clinical Professionals: On October 15, 2010 Drs. Perera, Oberfield, and Rundle presented to the Columbia University Medical Center Pediatrics Department on prenatal exposures to endocrine disruptors. In total, Center investigators made 19 presentations to scientific or clinical groups during the year.
- Communications: In collaboration with the Department of External Affairs at Mailman School of Public Health and CCCEH investigators, COTC staff assisted in the development and dissemination of press releases about Center-related findings.
- Capacity Building & Informing Policy: During the past year, the Center Director and investigators presented findings to staff of the NIEHS Office of Pesticide Programs (Whyatt, Rauh), to the U.S. Senate Field Hearing on Toxic Chemicals and Children's Health hosted by Senator Lautenberg of NJ (Perera) and Dr. Evans was invited to join the Children’s Health Working Group convened by Senator Gillibrand of NY to solicit advice on food safety and environmental policy. WE ACT Executive Director Peggy Shepherd and other staff members continue to use Center research findings in their ongoing policy reform efforts.
Future Activities:
R834509C001: Endocrine Disruptors and Obesity among Inner-City Children
We will continue to follow the children and assess them as they to age in.
R834509C002: Endocrine Disrupters, Epigenetic Mechanisms & Neurodevelopment
We will be exploring the association between prenatal and postnatal BPA exposure and various childhood outcomes, as well as contiuing our PAH and gene work. We will also continue administering the age 9-11 battery to the children as they age in.
R834509C003: Molecular/disease consequences of prenatal BPA, PAH exposure across generations
In the next 6 months, we plan to complete the gene expression analysis of the fetal and juvenile tissue samples. In the upcoming year, murine experiments on prenatal PAH exposure on neurodevelopmental, obesity and epigenetic outcomes will commence.
Adminstrative Core
The Core provides essential administrative support to Center investigators and will continue in this role.
Data Management, Statistics and Community Modeling Core
An annual update of GIS data for all subjects will commence in August 2011. The 2011 update will contain geocoded information for all current addresses at the time of interview through age 11 years.
Community Outreach and Translation Core
COTC staff will complete development of educational materials for BPA for community members and continue to make presentations to groups of residents hosted by CASB member organizations. In addition we will present the first workshop on endocrine disrupters for clinicians. COTC staff will also organize a family event for study participants in August 2011. The event will encourage retention and CCCEH and WE ACT will provide health education resources to CCCEH Northern Manhattan/South Bronx cohort families.
Journal Articles: 60 Displayed | Download in RIS Format
Other center views: | All 104 publications | 62 publications in selected types | All 60 journal articles |
---|
Type | Citation | ||
---|---|---|---|
|
Albert DA, Begg MD, Andrews HF, Williams SZ, Ward A, Conicella ML, Rauh V, Thompson JL, Papapanou PN. An examination of periodontal treatment, dental care, and pregnancy outcomes in an insured population in the United States. American Journal of Public Health 2011;101(1):151-156. |
R834509 (Final) |
Exit |
|
Buckley JP, Engel SM, Braun JM, Whyatt RM, Daniels JL, Mendez MA, Richardson DB, Xu Y, Calafat AM, Wolff MS, Lanphear BP, Herring AH, Rundle AG. Prenatal phthalate exposures and body mass index among 4- to 7-year-old children: a pooled analysis. Epidemiology 2016;27(3):449-458. |
R834509 (Final) R834509C001 (Final) |
Exit |
|
Choi H, Wang L, Lin X, Spengler JD, Perera FP. Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS One 2012;7(4):e35464 (11 pp.). |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) R827027 (2002) R832141 (Final) |
Exit Exit Exit |
|
Choi H, Perera FP. Sources of greater fetal vulnerability to airborne polycyclic aromatic hydrocarbons among African Americans. Journal of Epidemiology and Community Health 2012;66(2):121-126. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) R827027 (2002) R832141 (Final) |
Exit Exit |
|
Durham T, Guo J, Cowell W, Riley K, Wang S, Tang D, Perera F, Herbstman J. Prenatal PM2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery. Toxics 23;10(1):13. |
R834509 (Final) R827027 (2002) R832141 (Final) R836154 (Final) |
Exit Exit |
|
Genkinger JM, Stigter L, Jedrychowski W, Huang T-J, Wang S, Roen EL, Majewska R, Kieltyka A, Mroz E, Perera FP. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6-9. Environmental Research 2015;140:136-144. |
R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Herbstman JB, Tang D, Zhu D, Qu L, Sjodin A, Li Z, Camann D, Perera FP. Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood. Environmental Health Perspectives 2012;120(5):733-738. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (2012) R834509C002 (Final) |
|
|
Herbstman JB, Wang S, Perera FP, Lederman SA, Vishnevetsky J, Rundle AG, Hoepner LA, Qu L, Tang D. Predictors and consequences of global DNA methylation in cord blood and at three years. PLoS One 2013;8(9):e72824 (10 pp.). |
R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit |
|
Hoepner LA, Whyatt RM, Just AC, Calafat AM, Perera FP, Rundle AG. Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years. Environmental Research 2013;122:38-44. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C001 (2012) R834509C001 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Hoepner LA, Whyatt RM, Widen EM, Hassoun A, Oberfield SE, Mueller NT, Diaz D, Calafat AM, Perera FP, Rundle AG. Bisphenol A and adiposity in an inner-city birth cohort. Environmental Health Perspectives 2016;124(10):1644-1650. |
R834509 (Final) R836154 (2017) |
|
|
Iyer S, Perera F, Zhang B, Chanock S, Wang S, Tang D. Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. Carcinogenesis 2014;35(1):69-75. |
R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Jung KH, Bernabe K, Moors K, Yan B, Chillrud SN, Whyatt R, Camann D, Kinney PL, Perera FP, Miller RL. Effects of floor level and building type on residential levels of outdoor and indoor polycyclic aromatic hydrocarbons, black carbon, and particulate matter in New York City. Atmosphere 2011;2(2):96-109. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Jung KH, Perzanowski M, Rundle A, Moors K, Yan B, Chillrud SN, Whyatt R, Camann D, Perera FP, Miller RL. Polycyclic aromatic hydrocarbon exposure, obesity and childhood asthma in an urban cohort. Environmental Research 2014;128:35-41. |
R834509 (2014) |
Exit Exit Exit |
|
Jung KH, Liu B, Lovinsky-Desir S, Yan B, Camann D, Sjodin A, Li Z, Perera F, Kinney P, Chillrud S, Miller RL. Time trends of polycyclic aromatic hydrocarbon exposure in New York City from 2001 to 2012: assessed by repeat air and urine samples. Environmental Research 2014;131:95-103. |
R834509 (2014) R834509 (Final) R834509C002 (Final) R832096 (Final) |
Exit Exit Exit |
|
Jung K, Goowin K, Perzanowski M, Chillrud S, Perera F, Miller R, Lovinsky-Desir S. Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City. Environmental Health Prespectives 2021;129(9). |
R834509 (Final) R832141 (Final) |
|
|
Kundakovic M, Champagne FA. Epigenetic perspective on the developmental effects of bisphenol A. Brain, Behavior, and Immunity 2011;25(6):1084-1093. |
R834509 (2011) R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C003 (2012) R834509C003 (Final) |
Exit Exit Exit |
|
Kundakovic M, Gudsnuk K, Franks B, Madrid J, Miller RL, Perera FA. Champagne FA. Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. Proceedings of the National Academy of Sciences of the United States of America 2013;110(24):9956-9961. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C003 (Final) |
Exit Exit Exit |
|
Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA. DNA methylation of BDNF as a biomarker of early-life adversity. Proceedings of the National Academy of Sciences of the United States of America 2015;112(22):6807-6813. |
R834509 (2014) R834509 (Final) R834509C003 (Final) |
Exit Exit Exit |
|
Lovasi GS, Quinn JW, Rauh VA, Perera FP, Andrews HF, Garfinkel R, Hoepner L, Whyatt R, Rundle A. Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment. American Journal of Public Health 2011;101(1):63-70. |
R834509 (2011) R834509 (Final) R827027 (2002) R832141 (Final) |
Exit Exit |
|
Lovasi GS, O’Neil-Dunne JPM, Lu JWT, Sheehan D, Perzanowski MS, MacFaden SW, King KL, Matte T, Miller RL, Hoepner LA, Perera FP, Rundle A. Urban tree canopy and asthma, wheeze, rhinitis, and allergic sensitization to tree pollen in a New York City birth cohort. Environmental Health Perspectives 2013;121(4):494-500. |
R834509 (Final) R827027 (2002) R832141 (Final) |
|
|
Lovasi GS, Eldred-Skemp N, Quinn JW, Chang HW, Rauh VA, Rundle A, Orjuela MA, Perera FP. Neighborhood social context and individual polycyclic aromatic hydrocarbon exposures associated with child cognitive test scores. Journal of Child and Family Studies 2014;23(5):785-799. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit |
|
Lovinsky-Desir S, Miller RL. Epigenetics, asthma, and allergic diseases:a review of latest advancements. Current Allergy and Asthma Reports 2012;12(3):211-220. |
R834509 (2012) R834509 (2013) R834509 (Final) R834509C003 (2012) R834509C003 (Final) |
Exit |
|
Maresca MM, Hoepner LA, Hassoun A, Oberfield SE, Mooney SJ, Calafat AM, Ramirez J, Freyer G, Perera FP, Whyatt RM, Rundle AG. Prenatal exposure to phthalates and childhood body size in an urban cohort. Environmental Health Perspectives 2015 June 12 [Epub ahead of print], doi:10.1289/ehp.1408750. |
R834509 (2013) R834509C001 (Final) R836154 (2017) |
|
|
Maresca MM, Hoepner LA, Hassoun A, Oberfield SE, Mooney SJ, Calafat AM, Ramirez J, Freyer G, Perera FP, Whyatt RM, Rundle AG. Prenatal exposure to phthalates and childhood body size in an urban cohort. Environmental Health Perspectives 2016;124(4):514-520. |
R834509 (Final) |
|
|
Margolis AE, Herbstman JB, Davis KS, Thomas VK, Tang D, Wang Y, Wang S, Perera FP, Peterson BS, Rauh VA. Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence. Journal of Child Psychology and Psychiatry 2016;57(7):851-860. |
R834509 (Final) R836154 (2017) |
Exit Exit |
|
Miller RL, Garfinkel R, Lendor C, Hoepner L, Li Z, Romanoff L, Sjodin A, Needham L, Perera FP, Whyatt RM. Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort. Pediatric Allergy and Immunology 2010;21(2 Pt 1):260-267. |
R834509 (2011) R834509 (Final) R832096 (Final) R832141 (2007) R832141 (Final) |
Exit |
|
Mueller NT, Whyatt R, Hoepner L, Oberfield S, Dominguez-Bello MG, Widen EM, Hassoun A, Perera F, Rundle A. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. International Journal of Obesity 2015;39(4):665-670. |
R834509 (2014) R834509 (Final) R834509C001 (Final) |
Exit |
|
Nobel KG, Fifer WP, Rauh VA, Nomura Y, Andrews HF. Academic achievement varies with gestational age among children born at term. Pediatrics 2012;130(2):e257-e264. |
R834509 (Final) |
Exit Exit |
|
Orjuela MA, Liu X, Warburton D, Siebert AL, Cujar C, Tang D, Jobanputra V, Perera FP. Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood. Mutation Research 2010;703(2):108-114. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Orjuela MA, Liu X, Miller RL, Warburton D, Tang D, Jobanputra V, Hoepner L, Suen IH, Diaz-Carreno S, Li Z, Sjodin A, Perera FP. Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children. Cancer Epidemiology, Biomarkers & Prevention 2012;21(7):1191-1202. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) R832096 (Final) |
Exit Exit Exit |
|
Patel MM, Hoepner L, Garfinkel R, Chillrud S, Reyes A, Quinn JW, Perera F, Miller RL. Ambient metals, elemental carbon, and wheeze and cough in New York City children through 24 months of age. American Journal of Respiratory and Critical Care Medicine 2009;180(11):1107-1113. |
R834509 (2011) R834509 (Final) R827027 (2002) R832141 (2007) R832141 (Final) |
Exit Exit Exit |
|
Perera FP, Li Z, Whyatt R, Hoepner L, Wang S, Camann D, Rauh V. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 2009;124(2):e195-e202. |
R834509 (2014) R834509 (Final) R834509C002 (Final) R832141 (Final) |
Exit |
|
Perera FP, Wang S, Vishnevetsky J, Zhang B, Cole KJ, Tang D, Rauh V, Phillips DH. Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York City children. Environmental Health Perspectives 2011;119(8):1176-1181. |
R834509 (2011) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
|
|
Perera FP, Tang D, Wang S, Vishnevetsky J, Zhang B, Diaz D, Camann D, Rauh V. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environmental Health Perspectives 2012;120(6):921-926. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (2012) R834509C002 (Final) |
|
|
Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, Huang TJ, Miller RL, Wang S, Rauh V. Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One 2014;9(11):e111670 (9 pp.). |
R834509 (2014) R834509 (Final) R834509C002 (Final) R832096 (Final) |
Exit Exit |
|
Perera F, Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology 2011;31(3):363-373. |
R834509 (2011) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Perera F, Vishnevetsky J, Herbstman JB, Calafat AM, Xiong W, Rauh V, Wang S. Prenatal bisphenol A exposure and child behavior in an inner-city cohort. Environmental Health Perspectives 2012;120(8):1190-1194. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (2012) R834509C002 (Final) |
|
|
Perera F, Weiland K, Neidell M, Wang S. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and IQ:estimated benefit of pollution reduction. Journal of Public Health Policy 2014;35(3):327-336. |
R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit |
|
Perera F, Phillips DH, Wang Y, Roen E, Herbstman J, Rauh V, Wang S, Tang D. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development. Environmental Research 2015;142:602-608. |
R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Peterson BS, Rauh VA, Bansal R, Hao X, Toth Z, Nati G, Walsh K, Miller RL, Arias F, Semanek D, Perera F. Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 2015;72(6):531-540. |
R834509 (Final) R834509C002 (Final) R832096 (Final) |
Exit |
|
Rauh VA, Horton MK, Miller RL, Whyatt RM, Perera F. Neonatology and the environment:impact of early exposure to airborne environmental toxicants on infant and child neurodevelopment. Neoreviews 2010;11(7):363-369. |
R834509 (2011) R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) R834509C003 (2012) R834509C003 (Final) |
Exit Exit |
|
Roen EL, Wang Y, Calafat AM, Wang S, Margolis A, Herbstman J, Hoepner LA, Rauh V, Perera FP. Bisphenol A exposure and behavioral problems among inner city children at 7-9 years of age. Environmental Research 2015;142:739-745. |
R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit Exit |
|
Rundle AG, Gallagher D, Herbstman JB, Goldsmith J, Holmes D, Hassoun A, Oberfield S, Miller RL, Andrews H, Widen EM, Hoepner LA. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and childhood growth trajectories from age 5-14 years. Environmental research 2019;177:108595. |
R834509 (Final) R827027 (2002) R832141 (Final) |
Exit Exit |
|
Rundle A, Hoepner L, Hassoun A, Oberfield S, Freyer G, Holmes D, Reyes M, Quinn J, Camann D, Perera F, Whyatt R. Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy. American Journal of Epidemiology 2012;175(11):1163-1172. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C001 (2012) R834509C001 (Final) |
Exit Exit Exit |
|
Rundle A, Rauh VA, Quinn J, Lovasi G, Transande L, Susser E, Andrews HF. Use of community-level data in the National Children’s Study to establish the representativeness of segment selection in the Queens Vanguard Site. International Journal of Health Geographics 2012;11:18 (11 pp.). |
R834509 (Final) |
Exit Exit |
|
Tang WY, Levin L, Talaska G, Cheung YY, Herbstman J, Tang D, Miller RL, Perera F, Ho SM. Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells. Environmental Health Perspectives 2012;120(8):1195-1200. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (2012) R834509C002 (Final) |
|
|
Vishnevetsky J, Tang D, Chang HW, Roen EL, Wang Y, Rauh V, Wang S, Miller RL, Herbstman J, Perera FP. Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ. Neurotoxicology and Teratology 2015;49:74-80. |
R834509 (2014) R834509 (Final) R834509C002 (Final) R832096 (Final) |
Exit Exit Exit |
|
Wang S, Chanock S, Tang D, Li Z, Edwards S, Jedrychowski W, Perera FP. Effect of gene-environment interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Annals of Human Genetics 2010;74(1):46-56. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) R832141 (2007) R832141 (Final) |
Exit Exit Exit |
|
Wang S, Yu Z, Miller RL, Tang D, Perera FP. Methods for detecting interactions between imprinted genes and environmental exposures using birth cohort designs with mother-offspring pairs. Human Heredity 2011;71(3):196-208. |
R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit |
|
Wang S, Xiong W, Ma W, Chanock S, Jedrychowski W, Wu R, Perera FP. Gene-environment interactions on growth trajectories. Genetic Epidemiology 2012;36(3):206-213. |
R834509 (2012) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (2012) R834509C002 (Final) |
Exit Exit |
|
Wang Y, Perera F, Guo J, Riley K, Durham T, Ross Z, Ananth C, Baccarelli A, Wang S, Herbstman J. A methodological pipeline to generate an epigenetic marker of prenatal exposure to air pollution indicators. Epigenetics 2021;1-9. |
R834509 (Final) R827027 (2002) R832141 (Final) |
Exit |
|
Weiland K, Neidell M, Rauh V, Perera F. Cost of developmental delay from prenatal exposure to airborne polycyclic aromatic hydrocarbons. Journal of Health Care for the Poor and Underserved 2011;22(1):320-329. |
R834509 (2011) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
Exit Exit |
|
Widen EM, Whyatt RM, Hoepner LA, Ramirez-Carvey J, Oberfield SE, Hassoun A, Perera FP, Gallagher D, Rundle AG. Excessive gestational weight gain is associated with long-term body fat and weight retention at 7 y postpartum in African American and Dominican mothers with underweight, normal, and overweight prepregnancy BMI. American Journal of Clinical Nutrition 2015;102(6):1460-1467. |
R834509 (Final) R834509C001 (Final) |
Exit Exit |
|
Widen EM, Whyatt RM, Hoepner LA, Mueller NT, Ramirez-Carvey J, Oberfield SE, Hassoun A, Perera FP, Gallagher D, Rundle AG. Gestational weight gain and obesity, adiposity and body size in African-American and Dominican children in the Bronx and Northern Manhattan. Maternal and Child Nutrition 2016;12(4):918-928. |
R834509 (Final) |
Exit Exit |
|
Widen E, Burns N, Daniels M, Backlund G, Rickman R, Foster S, Nichols A, Hoepner L, Kinsey E, Ramireaz-Carvey J. Gestational weight change and childhood body composition trajectories from pregnancy to early adolescence. Obesity 10;. |
R834509 (Final) R827027 (2002) R832141 (Final) |
Exit Exit |
|
Widen E, Nichols A, Kahn L, Factor-Livak P, Insel B, Hoepner L, Dube S, Rauh V, Perera F, Rundel A. Prepregnancy obesity is associated with cognitive outcomes in boys in a low-income, multiethnic birth cohort. BMC Pediatrics 2019;19(1):507. |
R834509 (Final) R827027 (2002) |
Exit Exit |
|
Witherspoon NO, Trousdale K, Bearer CF, Miller RL. The public health and policy implications of epigenetics and pediatric health research. Environmental Health Perspectives 2012;120(10):a380-a381. |
R834509 (2012) R834509 (2013) R834509C003 (2012) |
|
|
Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, McDonald JD, Yan B, Schwartz GJ, Miller RL. Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice. PLoS One 2014;9(10):e110706 (15 pp.). |
R834509 (2014) R834509 (Final) R834509C003 (Final) |
Exit Exit |
|
Zeinomar N, Grant-Alfieri A, Burke K, de Hoz M, Tehranifar P, Walker D, Morton T, Shepard P, Herbstman J, Miller R, Pera F, Terry M. Cancer Risk Reduction Through Education of Adolescents:Development of a Tailored Cancer Risk-Reduction Educational Tool. Journal of Cancer Education 2021;. |
R834509 (Final) R827027 (2002) R832141 (Final) |
Exit Exit |
|
Widen EM, Whyatt RM, Hoepner LA, Mueller NT, Ramirez‐Carvey J, Oberfield SE, Hassoun A, Perera FP, Gallagher D, Rundle AG. Gestational weight gain and obesity, adiposity and body size in African-American and Dominican children in the Bronx and Northern Manhattan. Maternal & Child Nutrition 2016;12(4):918-928. |
R834509C001 (Final) R836154 (2017) |
Exit |
Supplemental Keywords:
bisphenol A, polycyclic aromatic hydrocarbons, obesity, neurodevelopment, children, administration, statistics, geographic information systems (GIS), community outreach, research translation;Relevant Websites:
Columbia Center for Children's Environmental Health ExitProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834509C001 The Role of Endocrine Disruptors in Childhood Obesity
R834509C002 The Role of Endocrine Disruptors in Neurodevelopmental Disorders
R834509C003 The Mechanisms of Endocrine Disruptors in Laboratory Mice
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.