Grantee Research Project Results
Final Report: Biomarkers of PAH Exposure and Asthma in an Inner City Birth Cohort
EPA Grant Number: R832096Title: Biomarkers of PAH Exposure and Asthma in an Inner City Birth Cohort
Investigators: Miller, Rachel L. , Whyatt, Robin M. , Perera, Frederica P.
Institution: Columbia University in the City of New York
EPA Project Officer: Aja, Hayley
Project Period: December 1, 2004 through December 31, 2007
Project Amount: $749,872
RFA: Application of Biomarkers to Environmental Health and Risk Assessment (2004) RFA Text | Recipients Lists
Research Category: Biomarkers to Environmental Health and Risk Assessment
Objective:
Living in areas with high volumes of traffic has been associated with asthma in children. Research suggests that the polycyclic aromatic hydrocarbon (PAH)s may be the biologically active components that increase the risk of airway allergic inflammation that characterizes most asthma. But direct associations between exposure to PAHs, biomarkers for PAH exposure, and the onset of immunological or clinical signs of asthma have not yet been demonstrated. We hypothesized that biomarkers for PAH exposure at age 5 years will help predict increased risk for asthma. Specifically, we propose to 1: Determine whether a) increased PAH levels in the air, or b) increased PAH DNA adducts in the blood of 5 year olds, are associated with increased urinary PAH metabolites in an inner city birth cohort, 2: Determine whether increased urinary PAH metabolites are associated with early indicators of asthma or allergy, 3: Determine whether the presence of increased urinary PAH metabolites increases the association between levels of allergens in home dust and indicators of asthma or allergy. Our strategy is to take advantage of an established Northern Manhattan birth cohort as part of Columbia Center for Children's Environmental Health in which multiple environmental exposures, biomarkers, and health outcomes already are being measured prospectively.Summary/Accomplishments (Outputs/Outcomes):
1. Recruitment of subjects: Recruitment was complete at n=222 study participants.
2. Analyses for urinary PAH metabolites: Analysis of 23 urinary PAH metabolites was completed by the Centers for Disease Control laboratories and their levels (unadjusted and specific gravity corrected) were evaluated with asthma outcomes and IgE levels
3. Results: Full results will be reported following publication of manuscript in peer-reviewed journal. PAH metabolite levels were readily detectable and positively associated with outcomes of interest.
Expenditures: There are no outstanding expenditures on account 5-23053 for project EPA RD 832096. The account is fully spent and pending close-out.
All quality assurance requirements of 40 C.F.R. 30.54 were met. The CDC Quality Assurance Program consisted of preparing spiked pools, characterizing the levels of the metabolites in these pools by repetitive measurements, and using these characterized values to establish mean and 95% and 99% control limits for each analyte in each pool.
Journal Articles on this Report : 7 Displayed | Download in RIS Format
| Other project views: | All 10 publications | 8 publications in selected types | All 7 journal articles |
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Jung KH, Liu B, Lovinsky-Desir S, Yan B, Camann D, Sjodin A, Li Z, Perera F, Kinney P, Chillrud S, Miller RL. Time trends of polycyclic aromatic hydrocarbon exposure in New York City from 2001 to 2012: assessed by repeat air and urine samples. Environmental Research 2014;131:95-103. |
R832096 (Final) R834509 (2014) R834509 (Final) R834509C002 (Final) |
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Jung KH, Lovinsky-Desir S, Perzanowski M, Liu X, Maher C, Gil E, Torrone D, Sjodin A, Li Z, Perera FP, Miller RL. Repeatedly high polycyclic aromatic hydrocarbon exposure and cockroach sensitization among inner-city children. Environmental Research 2015;140:649-656. |
R832096 (Final) |
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Miller RL, Garfinkel R, Lendor C, Hoepner L, Li Z, Romanoff L, Sjodin A, Needham L, Perera FP, Whyatt RM. Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort. Pediatric Allergy and Immunology 2010;21(2 Pt 1):260-267. |
R832096 (Final) R832141 (2007) R832141 (Final) R834509 (2011) R834509 (Final) |
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Orjuela MA, Liu X, Miller RL, Warburton D, Tang D, Jobanputra V, Hoepner L, Suen IH, Diaz-Carreno S, Li Z, Sjodin A, Perera FP. Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children. Cancer Epidemiology, Biomarkers & Prevention 2012;21(7):1191-1202. |
R832096 (Final) R834509 (2013) R834509 (2014) R834509 (Final) R834509C002 (Final) |
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Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, Huang TJ, Miller RL, Wang S, Rauh V. Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One 2014;9(11):e111670 (9 pp.). |
R832096 (Final) R834509 (2014) R834509 (Final) R834509C002 (Final) |
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Peterson BS, Rauh VA, Bansal R, Hao X, Toth Z, Nati G, Walsh K, Miller RL, Arias F, Semanek D, Perera F. Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 2015;72(6):531-540. |
R832096 (Final) R834509 (Final) R834509C002 (Final) |
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Vishnevetsky J, Tang D, Chang HW, Roen EL, Wang Y, Rauh V, Wang S, Miller RL, Herbstman J, Perera FP. Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ. Neurotoxicology and Teratology 2015;49:74-80. |
R832096 (Final) R834509 (2014) R834509 (Final) R834509C002 (Final) |
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Supplemental Keywords:
Polycylic Aromatic Hydrocarbons (PAHs), urinary metabolites, RFA, Health, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, particulate matter, genetic susceptability, Environmental Chemistry, Allergens/Asthma, Environmental Monitoring, sensitive populations, health risks, inner city, chemical characteristics, airway inflammation, asthma indices, asthma triggers, asthma, Manhattan, aerosol composition, airborne particulate matter, human exposure, ambient air monitoring, environmental risks, second hand smoke, atmospheric particles, atmospheric aerosol particles, particulates, exposure, atmospheric particulate matter, airborne pollutants, allergic response, ambient air quality, air pollution, human health risk, human susceptibility, PAH, air toxics, inhalation, airway diseaseProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.