Grantee Research Project Results
2011 Progress Report: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
EPA Grant Number: R833741Title: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
Investigators: Larson, Timothy V. , Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Simpson, Chris , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Daviglus, Martha , Adar, Sara D.
Current Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Szpiro, Adam , Simpson, Chris , Jacobs, David , Daviglus, Martha
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Wake Forest University , University of Minnesota
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of Minnesota , Wake Forest University
EPA Project Officer: Chung, Serena
Project Period: March 1, 2008 through February 28, 2013
Project Period Covered by this Report: March 1, 2011 through February 29,2012
Project Amount: $1,199,217
RFA: Sources, Composition, and Health Effects of Coarse Particulate Matter (2006) RFA Text | Recipients Lists
Research Category: Air , Air Quality and Air Toxics , Particulate Matter
Objective:
The primary objectives of this project are to: 1) characterize the within-city spatial variability of PM10-2.5 from natural and anthropogenic sources using a spatially intensive approach; and 2) examine associations of PM10-2.5 with cardiovascular and respiratory disease. We hypothesize that geographically varying parameters such as proximity to roadway, land use, and vegetative indices will be predictive of total PM10-2.5 mass and source-specific component concentrations measured at different locations. We further hypothesize that increased long-term exposures to PM10-2.5, especially to traffic-associated PM10-2.5, are associated with increased clinical cardiovascular events, as well as a more rapid sub-clinical progression of atherosclerosis and emphysema.
Progress Summary:
Figure 1: Measured concentrations of PM10-2.5 by city and season.
City | Season | LUR | UK | ||
---|---|---|---|---|---|
R2 | RMSE | R2 | RMSE | ||
Chicago, IL | Winter | 0.88 | 0.67 | 0.88 | 0.67 |
Summer | 0.68 | 1.19 | 0.68 | 1.19 | |
Pool | 0.68 | 1.14 | 0.65 | 1.20 | |
St. Paul, MN | Winter | 0.66 | 2.03 | 0.65 | 2.05 |
Summer | 0.64 | 1.99 | 0.63 | 2.02 | |
Pool | 0.57 | 2.48 | 0.58 | 2.46 | |
Winston-Salem, NC | Winter | 0.48 | 0.88 | 0.48 | 0.97 |
Summer | 0.76 | 0.85 | 0.76 | 0.85 | |
Pool | 0.32 | 1.21 | 0.33 | 1.20 |
Future Activities:
The next steps for this project are to publish our exposure findings and complete our epidemiological analyses. Draft manuscripts on the spatial modeling of PM10-2.5 mass and key components have been written and are currently under review with co-authors. A third paper on our PMF models is under preparation. We are concurrently focusing our main efforts on completing the planned epidemiologic analyses of the relations between PM10-2.5 mass and key components with the progression of atherosclerosis, lung density (a measure of emphysema), and clinical events. We will also continue to explore with secondary endpoints and publish these findings. This will include inflammation in the blood and right ventricular mass/function for which written manuscripts are ready to be circulated co-authors.
Journal Articles:
No journal articles submitted with this report: View all 18 publications for this projectSupplemental Keywords:
RFA, Scientific Discipline, Air, particulate matter, Health Risk Assessment, Biology, atmospheric particulate matter, sensitive populations, atmospheric particles, cardiopulmonary responses, human health effects, bioavailability, cardiovascular vulnerability, sensitive subgroups, cardiotoxicity, exposure assessmentProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.