Grantee Research Project Results
2010 Progress Report: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
EPA Grant Number: R833741Title: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Szpiro, Adam , Simpson, Chris , Jacobs, David , Daviglus, Martha
Institution: University of Washington , Northwestern University , University of Michigan , Wake Forest University , University of Minnesota , Columbia University in the City of New York
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of Minnesota , Wake Forest University
EPA Project Officer: Chung, Serena
Project Period: March 1, 2008 through February 28, 2013
Project Period Covered by this Report: March 1, 2010 through February 28,2011
Project Amount: $1,199,217
RFA: Sources, Composition, and Health Effects of Coarse Particulate Matter (2006) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air
Objective:
The primary aims of this project are to: 1) characterize the within-city spatial variability of coarse particles from natural and anthropogenic sources using a spatially intensive approach; and 2) examine associations of coarse particles with cardiovascular and respiratory disease. We hypothesize that geographically varying parameters such as proximity to roadway, land use, and land cover indices will be predictive of total coarse mass and source-specific component concentrations measured at different locations. We further hypothesize that increased long-term exposures to coarse particles, especially to traffic-associated coarse particles or particles high in endotoxin, are associated with increased clinical cardiovascular events, as well as a more rapid sub-clinical progression of atherosclerosis and emphysema.
Progress Summary:
Over the past year, MESA Coarse has been productive with substantial progress made on completing Specific Aim 1 of the grant. We have finished chemical and biological analyses on all samples collected in Years 1 and 2, finalized our analytic datasets, and undergone a successful quality assurance audit by our Quality Assurance Officer. In accordance with our proposed timeline, we also have conducted spatial exposure modeling in each of our three cities using a rigorous modeling approach and creating predictions of PM10-2.5 mass for each participant as a function of geographic covariates. Our models had good predictive power with approximate cross-validated R2 of 0.7, 0.5, and 0.5 in Chicago, St. Paul, and Winston-Salem, respectively. We also have completed planned multivariate source apportionment modeling to identify mixtures and markers of important sources of coarse mass and have begun creating spatial prediction models for tracers of traffic and windblown soil. Epidemiological analyses currently are underway and we have found evidence of retinal arteriolar narrowing with increasing concentrations of PM10-2.5 mass in our early health modeling. These associations were robust to control for traditional risk factors and PM2.5 concentrations.
Future Activities:
The next steps for this project are to submit a manuscript on the spatial modeling of PM10-2.5 mass developed for each city and to finalize additional models for PM10-2.5 components. We also plan to examine the incorporation of deterministic modeling and/or satellite data to improve our model predictions. Concentrations then will be estimated at homes where sampling did not occur so that we can conduct epidemiologic analyses with predicted exposures. We soon will examine relationships between PM10-2.5 mass and components and the progression of atherosclerosis, retinal microvasculature, lung density (a measure of emphysema), and events (including both cardiac outcomes and respiratory hospitalizations).
Journal Articles:
No journal articles submitted with this report: View all 19 publications for this projectSupplemental Keywords:
Air pollution, health effects, human health, air sampling, endotoxin, chemical speciation, RFA, Air, Scientific Discipline, Health Risk Assessment, particulate matter, Biology, bioavailability, sensitive populations, sensitive subgroups, atmospheric particles, cardiopulmonary responses, cardiovascular vulnerability, cardiotoxicity, atmospheric particulate matter, chemical speciation sampling, human health effectsProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.