Grantee Research Project Results
2009 Progress Report: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
EPA Grant Number: R833741Title: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Simpson, Chris , Jacobs, David , Daviglus, Martha
Current Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Szpiro, Adam , Simpson, Chris , Jacobs, David , Daviglus, Martha
Institution: University of Washington , Northwestern University , University of Minnesota , Wake Forest University , Columbia University in the City of New York
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of Minnesota , Wake Forest University
EPA Project Officer: Chung, Serena
Project Period: March 1, 2008 through February 28, 2013
Project Period Covered by this Report: March 1, 2009 through February 28,2010
Project Amount: $1,199,217
RFA: Sources, Composition, and Health Effects of Coarse Particulate Matter (2006) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air
Objective:
The primary aims of this project are: 1) to characterize the within-city spatial variability of coarse particles from natural and anthropogenic sources using a spatially intensive approach; and 2) to examine associations of coarse particles with cardiovascular and respiratory disease. We hypothesize that geographically varying parameters such as proximity to roadway, land use, and land cover indices will be predictive of total coarse mass and source-specific component concentrations measured at different locations. We further hypothesize that increased long-term exposures to coarse particles, especially to traffic-associated coarse particles or particles high in endotoxin, are associated with increased clinical cardiovascular events, as well as a more rapid sub-clinical progression of atherosclerosis and emphysema.Progress Summary:
We have reached several major milestones during this, the second year, of the MESA Coarse grant. During this year, we completed our field deployment, conducting a second round of sampling in each of our three study cities. All “in-house” analyses (PM10, PM2.5, PM10-2.5, and light absorption coefficient [LAC]) have been completed on all of these filters. Analyses to be completed at external labs (trace elements, endotoxin) are well underway, with the majority of the filters analyzed for trace elements via XRF and endotoxin. All PM and LAC data has gone through a rigorous QA/QC process and the final quality assurance report on this data is nearly complete. Finally, we have begun to evaluate our data, and specifically have investigated the relationship between the annual average PM10-2.5 values from AQS monitors with the averages of the co-located summer and winter snapshot samples. We have also begun modeling the spatial variation in coarse mass using a land use regression approach.Future Activities:
The next steps for this project are to develop spatial models in each city for both particulate matter mass and components, to use these models to predict concentrations at homes where sampling did not occur, and finally to begin epidemiologic analyses with this predicted exposure to examine their relation to progression of atherosclerosis, impacts on the retinal microvasculature, lung density (a measure of emphysema), and events (including both cardiac outcomes and respiratory hospitalizations).Journal Articles:
No journal articles submitted with this report: View all 19 publications for this projectSupplemental Keywords:
Air pollution, health effects, human health, air sampling, endotoxin, chemical speciation, RFA, Air, Scientific Discipline, Health Risk Assessment, particulate matter, Biology, bioavailability, sensitive populations, sensitive subgroups, atmospheric particles, cardiopulmonary responses, cardiovascular vulnerability, cardiotoxicity, atmospheric particulate matter, chemical speciation sampling, human health effectsRelevant Websites:
NoneProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.