Grantee Research Project Results
2008 Progress Report: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
EPA Grant Number: R833741Title: Spatial Investigation of Sources, Composition, and Long-Term Health Effects of Coarse Particulate Matter (PM10-2.5) in the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort
Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Simpson, Chris , Jacobs, David , Daviglus, Martha
Current Investigators: Larson, Timothy V. , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Burke, Gregory L. , Szpiro, Adam , Simpson, Chris , Jacobs, David , Daviglus, Martha
Institution: University of Washington , Northwestern University , University of Minnesota , Wake Forest University , Columbia University in the City of New York
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of Minnesota , Wake Forest University
EPA Project Officer: Chung, Serena
Project Period: March 1, 2008 through February 28, 2013
Project Period Covered by this Report: March 1, 2008 through February 28,2009
Project Amount: $1,199,217
RFA: Sources, Composition, and Health Effects of Coarse Particulate Matter (2006) RFA Text | Recipients Lists
Research Category: Air , Air Quality and Air Toxics , Particulate Matter
Objective:
The primary aims of this project are to: 1) characterize the within-city spatial variability of coarse particles from natural and anthropogenic sources using a spatially intensive approach; and 2) examine associations of coarse particles with cardiovascular and respiratory disease, We hypothesize that geographically varying parameters such as proximity to roadway, land use, and land cover indices will be predictive of total coarse mass and source-specific component concentrations measured at different locations. We further hypothesize that increased long-term exposures to coarse particles, especially to traffic-associated coarse particles or particles high in endotoxin, are associated with increased clinical cardiovascular events, as well as a more rapid sub-clinical progression of atherosclerosis and emphysema.Progress Summary:
During the first year of this grant, we focused on both the development and refinement of our sampling methodology and on field deployment in each of our three cities. We have successfully obtained IRB approval from all sites, recruited sufficient participants for home sampling, completed one round of sampling in each city, and conducted preliminary exposure modeling based on early PM coarse mass data. Preliminary analyses demonstrate that we have been successful in oversampling near roads, commercial, and agricultural areas, as intended. In a simple and preliminary land use regression model analysis, we found that 62 percent of the variation in our data for the St. Paul area could be explained by the percentage of cropland, commercial land, and residential land within 300, 150, and 50 meters of a monitoring location, respectively.Future Activities:
During the second reporting period, we anticipate the completion of all field activities with a second round of data being collected in Chicago (May 2009), St. Paul (June 2009), Winston-Salem (July 2009), and a third round of sampling in Chicago (August 2009). All samples will be weighed for mass, reflected for light absorbing carbon, and sent to external laboratories for XRF metal speciation and endotoxin analysis. We will then work on developing spatial prediction models based on mass data and will conduct early health effects analyses based on EPA monitoring data.Journal Articles:
No journal articles submitted with this report: View all 18 publications for this projectSupplemental Keywords:
Air pollution, health effects, human health, air sampling, endotoxin, chemical speciation, RFA, Scientific Discipline, Air, particulate matter, Health Risk Assessment, Biology, atmospheric particulate matter, sensitive populations, atmospheric particles, cardiopulmonary responses, human health effects, bioavailability, cardiovascular vulnerability, sensitive subgroups, cardiotoxicity, exposure assessmentRelevant Websites:
None.
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.