Grantee Research Project Results

Hepatocyte Metabolism Model for Xenobiotics

EPA Grant Number: R832721C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832721
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: New Jersey Research Center for Environmental Bioinformatics and Computational Toxicology
Center Director: Welsh, William J.
Title: Hepatocyte Metabolism Model for Xenobiotics
Investigators: Ierapetritou, Marianthi , Androulakis, Ioannis
Current Investigators: Ierapetritou, Marianthi , Georgopoulos, Panos G. , Welsh, William J. , Floudas, Christodoulos , Rabitz, Herschel , Androulakis, Ioannis , Tong, Weida
Institution: Rutgers
Current Institution: Rutgers , Princeton University , U.S. Food and Drug Administration , University of Medicine and Dentistry of New Jersey
EPA Project Officer: Hahn, Intaek
Project Period: October 1, 2005 through September 30, 2010
RFA: Computational Toxicology: Environmental Bioinformatics Research Center (2004) RFA Text | Recipients Lists
Research Category: Computational Toxicology , Human Health , Safer Chemicals

Objective:

The aims of this project have not changed from the original application; original objectives for the report period have been met. However, specific collaborative case studies have been defined during the report period to facilitate testing and evaluating of the accomplishment of these aims.

Publications and Presentations:

Publications have been submitted on this subproject: View all 8 publications for this subproject | View all 330 publications for this center

Supplemental Keywords:

computational toxicology, toxicogenomics, bioinformatics, toxicoinformatics, proteomics, metabonomics, physiomics, cytomics, genomics, transcriptomics, enviroinformatics, cheminformatics, biologically based dose-response modeling, cross-species extrapolation, risk assessment,, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Geographic Area, State, Risk Assessments, Biochemistry, Environmental Monitoring, Biology, Risk Assessment, ecological risk assessment, risk, computational toxicology, toxicology, environmental risks, biopollution, chemical composition, New Jersey (NJ), human exposure, toxicologic assessment, bioinformatics, biochemical research, human health risk

Progress and Final Reports:

Main Center Abstract and Reports:

R832721 New Jersey Research Center for Environmental Bioinformatics and Computational Toxicology

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832721C001 Development and Application of the DORIAN (Dose-Response Information Analysis) System
R832721C002 Hepatocyte Metabolism Model for Xenobiotics
R832721C003 Development of Computational Tools for Optimal Identification of Biological Networks
R832721C004 Cheminformatics Tools for Toxicant Characterization
R832721C005 Optimization Tools for In Silico Structural Proteomics

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.