Grantee Research Project Results

2004 Progress Report: Metals Neurotoxicity Research Project

EPA Grant Number: R831725C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R831725
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Metals Neurotoxicity Research Project
Investigators: Maher, Tim , Weisskopf, Marc
Institution: Harvard University
EPA Project Officer: Callan, Richard
Project Period: June 1, 2004 through May 31, 2009 (Extended to May 31, 2011)
Project Period Covered by this Report: June 1, 2004 through May 31, 2005
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The objectives of this research project are to: (1) examine the effect of pre- and neonatal exposure to metals on neurochemical changes and neurobehavioral outcomes in rats; and (2) explore the potential modifying effect of stress on metals neurotoxicity.

Progress Summary:

Progress on Project 4 has been hindered by the delay in getting the subcontract to the Massachusetts College of Pharmacy finalized. We have, however, recently received the behavioral chambers for the Fixed-Ratio Waiting for Reward paradigm and are working out the details of the software programming. The Repeated Acquisition and Performance Chamber for the other behavioral paradigm currently is being designed and built. We are validating the High Performance Liquid Chromatography (HPLC) assays for dopamine, its metabolites, and glutamate. We also are finalizing the details of the assay for 8-OH-2’-dG and validating the assay.

Future Activities:

Pilot testing of animals should begin shortly. As soon as the subcontract is finalized, we will be able to purchase the autosampler for HPLC analyses. We anticipate significant progress in the months to come.

Journal Articles:

No journal articles submitted with this report: View all 12 publications for this subproject

Supplemental Keywords:

children, Native American, tribal, mixtures, lead, PBPK, community, Superfund, intervention, environmental management,, Health, RFA, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Waste, Hazardous, Health Risk Assessment, Environmental Chemistry, Hazardous Waste, Children's Health, Biochemistry, Risk Assessment, Human Health Risk Assessment, developmental toxicity, metal contamination, neurodevelopmental toxicity, mining wastes, fate and transport , mining waste, community-based intervention, human health risk, metals, metal wastes

Relevant Websites:

http://www.hsph.harvard.edu/niehs/children Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R831725 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831725C001 Metals, Nutrition, and Stress in Child Development
R831725C002 Exposure Assessment of Children and Metals in Mining Waste: Composition, Environmental Transport, and Exposure Patterns
R831725C003 Manganese, Iron, Cadmium, and Lead Transport from the Environment to Critical Organs During Gestation and Early Development in a Rat Model
R831725C004 Metals Neurotoxicity Research Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.