Grantee Research Project Results
2006 Progress Report: Endocrine Disrupting Chemicals and Thyroid Outcomes
EPA Grant Number: R830254Title: Endocrine Disrupting Chemicals and Thyroid Outcomes
Investigators: Anderson, Henry A.
Institution: Wisconsin Department of Health and Family Services
EPA Project Officer: Chung, Serena
Project Period: March 1, 2003 through February 28, 2007 (Extended to February 28, 2009)
Project Period Covered by this Report: March 1, 2006 through February 28,2007
Project Amount: $2,288,208
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text | Recipients Lists
Research Category: Environmental Justice , Endocrine Disruptors , Human Health , Safer Chemicals
Objective:
Measure polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and Hemoglobin A1C in 500 frequent and infrequent sport-fish consumers. Based on the study findings, determine whether there is an interaction between fish consumption and endocrine function.
Approach:
Fish consumption habits, other exposures to PBDEs and PCBs, diagnosed thyroid disease, medication use and demographic information will be assessed in the full cohort in a telephone interview. Biologic characterization of the major, endocrine disruptors known for this cohort will be conducted in 300 banked blood samples remaining from the original biologic sampling and in the newly selected 500 members. Eligibility for the new biomonitoring sample will be determined from the telephone interview. A more detailed survey and the blood and urine sampling will be conducted at field clinics. Urinary iodine, thyroid hormones, reproductive hormones, hemoglobin A1C (an index of integrated glucose concentration) and congener specific serum concentrations of PCBs, DDE and PBDEs (unadjusted and lipid adjusted) will be determined. Menstrual history and information on other potential confounds will be collected from women of reproductive age at the time of biologic specimen collection.
Progress Summary:
Data collection and laboratory analyses of blood serum and urine samples are complete. A screener questionnaire was mailed to a sample cohort of 3,865. Due to a low response rate of 49%, a non-responders survey was developed and a sample of 524 non-responders was drawn in 2005 (this survey had a 50% response rate). Comparison of demographic variables and fish consumption prevalence among participants and non-responders revealed that these two groups were comparable.Expected Results:
Age-adjusted prevalence rates of diabetes and thyroid conditions will be determined in the entire cohort and compared with age-adjusted rates for this population using standard statistical techniques. Cases of disease with onset since the previous data collection (1994) will be identified and the associations with sport fish consumption and with serum PBDE, PCB and DDE concentrations examined. The impact of possible confounding variables on these associations will also be determined.
Future Activities:
A subset of lab results will be sent to approximately 100 participants who have not yet received their results.Journal Articles on this Report : 3 Displayed | Download in RIS Format
Other project views: | All 58 publications | 30 publications in selected types | All 29 journal articles |
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Turyk ME, Anderson HA, Freels S, Chatterton Jr. R, Needham LL, Patterson Jr. DG, Steenport DN, Knobeloch L, Imm P, Persky VW, Great Lakes Consortium. Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environmental Research 2006;102(3):299-307. |
R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final) |
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Turyk M, Anderson HA, Hanrahan LP, Falk C, Steenport DN, Needham LL, Patterson Jr. DG, Freels S, Persky V, Great Lakes Consortium. Relationship of serum levels of individual PCB, dioxin, and furan congeners and DDE with Great Lakes sport-caught fish consumption. Environmental Research 2006;100(2):173-183. |
R830254 (2004) R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final) |
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Weisskopf MG, Anderson HA, Hanrahan LP, Kanarek MS, Falk CM, Steenport DM, Draheim LA, Great Lakes Consortium. Maternal exposure to Great Lakes sport-caught fish and dichlorodiphenyl dichloroethylene, but not polychlorinated biphenyls, is associated with reduced birth weight. Environmental Research 2005;97(2):149-162. |
R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final) |
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Supplemental Keywords:
endocrine, PCB, PBDE, thyroid, sport-fish, hormone, reproductive, groundwater, human health effects, age, race, sex, diet, epidemiology, monitoring, analytical techniques,, RFA, Health, Scientific Discipline, POLLUTANTS/TOXICS, HUMAN HEALTH, Exposure, Health Risk Assessment, Chemicals, Endocrine Disruptors - Environmental Exposure & Risk, Epidemiology, Risk Assessments, endocrine disruptors, Biochemistry, Molecular Biology/Genetics, Endocrine Disruptors - Human Health, chemical exposure, pesticide exposure, fish, endocrine disrupting chemicals, altered sexual development, bioavailability, exposure studies, PCBs, hormone degradation, fish consumption, human exposure, PCB, DDT, human growth and development, groundwater contamination, thyroid, reproductive processes, thyroid function, dietary exposure, agrochemicals, biochemical research, human health risk, epidemiologic studiesProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2007 Progress Report
- 2005 Progress Report
- 2004 Progress Report
- 2003 Progress Report
- Original Abstract
29 journal articles for this project