Grantee Research Project Results

2005 Progress Report: Endocrine Disrupting Chemicals and Thyroid Outcomes

EPA Grant Number: R830254
Title: Endocrine Disrupting Chemicals and Thyroid Outcomes
Investigators: Anderson, Henry A.
Institution: Wisconsin Department of Health and Family Services
EPA Project Officer: Chung, Serena
Project Period: March 1, 2003 through February 28, 2007 (Extended to February 28, 2009)
Project Period Covered by this Report: March 1, 2005 through February 28, 2006
Project Amount: $2,288,208
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text | Recipients Lists
Research Category: Endocrine Disruptors , Environmental Justice , Human Health , Safer Chemicals

Objective:

The objective of the research is to measure polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and Hemoglobin A1C in 500 frequent and infrequent sport fish consumers. Based on the study findings, it will be determined whether there is an interaction between fish consumption and endocrine function.

Progress Summary:

The first phase of the study is complete. A screener questionnaire was mailed to a sample cohort of 3,865. The data set from this survey was delivered in April 2006. Due to a low response rate of 49 percent, a nonresponders survey was developed and a sample of 524 nonresponders was drawn in 2005 (this survey had a 50% response rate). Comparison of demographic variables and fish consumption prevalence among participants and nonresponders revealed that these two groups were comparable.

The collection of data for the second phase of the study is complete. More than 600 respondents volunteered to participate by providing blood and urine samples and completing a more detailed health status and fish consumption questionnaire. Five-hundred twenty-one (521) respondents completed this phase of the study. Laboratory analysis of the samples currently is being conducted by two of three laboratories contracted to analyze the serum and urine. The laboratories conducting analysis for endocrine and thyroid function (Northwestern University) and chemical contaminant levels (Wisconsin State Lab of Hygiene) are continuing to test samples. Quest Diagnostics, the laboratory responsible for testing lipid levels, has completed all serum sample analyses. Thyroid and hormone levels will be measured for 89 Agency for Toxic Substances and Disease Registry (ATSDR) Repeat Biomarker samples as well. These participants in the ATSDR study also were members of the original Endocrine cohort but did not opt to participate in the Endocrine follow-up study, so their stored samples will be analyzed instead. Chemical contaminants already were measured as part of the ATSDR study.

Future Activities:

A subset of laboratory results will be sent to participants once all results are available.

Preliminary analysis of screener data will begin, as well as simple comparisons of fish consumption and health status data with the original 1993-1994 study. The data sets for the screener survey will be merged with the earlier study and also the Endocrine laboratory results and follow-up survey. With the loss of our data manager in September 2005, the project manager will be responsible for creation, quality control, and analysis of the data sets. More detailed analysis of follow-up participants and comparisons with earlier studies, such as the original 1993-1994 study and the ATSDR Original and Repeat Biomarker Studies, will begin but the data are expected to be more thoroughly analyzed in an extension year for the grant.

Journal Articles on this Report : 3 Displayed | Download in RIS Format

Publications Views
Other project views:	All 59 publications	31 publications in selected types	All 30 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Turyk ME, Anderson HA, Freels S, Chatterton Jr. R, Needham LL, Patterson Jr. DG, Steenport DN, Knobeloch L, Imm P, Persky VW, Great Lakes Consortium. Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environmental Research 2006;102(3):299-307.	R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final)	Abstract from PubMed Full-text: ScienceDirect Exit Abstract: ScienceDirect Exit Other: ScienceDirect PDF Exit
Journal Article	Turyk M, Anderson HA, Hanrahan LP, Falk C, Steenport DN, Needham LL, Patterson Jr. DG, Freels S, Persky V, Great Lakes Consortium. Relationship of serum levels of individual PCB, dioxin, and furan congeners and DDE with Great Lakes sport-caught fish consumption. Environmental Research 2006;100(2):173-183.	R830254 (2004) R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final)	Abstract from PubMed Full-text: Science Direct Exit Abstract: Science Direct Exit Other: Science Direct PDF Exit
Journal Article	Weisskopf MG, Anderson HA, Hanrahan LP, Kanarek MS, Falk CM, Steenport DM, Draheim LA, Great Lakes Consortium. Maternal exposure to Great Lakes sport-caught fish and dichlorodiphenyl dichloroethylene, but not polychlorinated biphenyls, is associated with reduced birth weight. Environmental Research 2005;97(2):149-162.	R830254 (2005) R830254 (2006) R830254 (2007) R830254 (Final)	Abstract from PubMed Full-text: ScienceDirect Exit Abstract: ScienceDirect Exit Other: ScienceDirect PDF Exit

Supplemental Keywords:

endocrine, PCB, PBDE, thyroid, sport-fish, hormone, reproductive,, Health, RFA, Scientific Discipline, HUMAN HEALTH, POLLUTANTS/TOXICS, Health Risk Assessment, Risk Assessments, Exposure, Epidemiology, Endocrine Disruptors - Human Health, Molecular Biology/Genetics, endocrine disruptors, Biochemistry, Endocrine Disruptors - Environmental Exposure & Risk, Chemicals, dietary exposure, altered sexual development, bioavailability, hormone degradation, thyroid function, groundwater contamination, human exposure, human growth and development, pesticide exposure, chemical exposure, PCB, thyroid, exposure studies, endocrine disrupting chemicals, reproductive processes, epidemiologic studies, human health risk, agrochemicals, PCBs, biochemical research, DDT, fish, Great Lakes

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.