Grantee Research Project Results

2000 Progress Report: Assessing Human Exposures to Particulate and Gaseous Air Pollutants

EPA Grant Number: R827353C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Assessing Human Exposures to Particulate and Gaseous Air Pollutants
Investigators: Koutrakis, Petros
Current Investigators: Koutrakis, Petros , Suh, Helen H. , Brown, Kathleen Ward , Sarnat, Jeremy
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2000 through May 31, 2001
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The overall objective of this project is to improve our ability to characterize air pollutant exposures for health effects studies. This project is one of three research studies proposed under Theme I: Assessing Particle Exposures for Health Effects Studies that were based on personal, indoor, and outdoor particulate and gas concentrations that were measured as part of our previous or current exposure studies. This project was intended to address Particulate Matter Research Topics 1, 5, and 7 identified by the National Research Council (NRC)- Outdoor Measures vs. Actual Exposures for Particles, Particle Components, and Gaseous Co-Pollutants. This project was intended to examine the ability of outdoor particulate concentrations to estimate exposures for a community.

Progress Summary:

We have performed a series of exposure studies in several cities located throughout the United States (Boston, MA; Baltimore, MD; Atlanta, GA; Los Angeles, CA; and Steubenville, OH). As part of these studies, we have collected several thousand simultaneous outdoor, indoor, and personal particle and gas samples for several potentially sensitive subgroups, including senior citizens, children, and individuals with chronic obstructive pulmonary disease (COPD) or recent myocardial infarctions (MI). For Atlanta and Steubenville, measurements of cardiovascular health status (heart rate, blood pressure, oxygen saturation, daily symptoms and medication use) also were collected for each participant. Data collection for the Steubenville and Atlanta studies was co-funded by the Center, while data collection for the remaining studies was supported by other agencies, such as the Health Effects Institute, the Electric Power Research Institute, the American Petroleum Institute, and the EPA (under a separate cooperative agreement).

As part of this project, we have begun to analyze data from these studies to investigate (1) the contribution of particles of outdoor and indoor origin to personal PM2.5 exposures, (2) the potential for confounding by gaseous pollutants to affect epidemiological study results, and (3) the ability of particles to penetrate from outdoor to indoor environments. To date, we have published or submitted four papers addressing these issues (Sarnat, et al., 2000; Sarnat, et al., in press; Long, et al., 2000; Long, et al., in press). Together, results from these studies indicate that home characteristics, such as ventilation, are the primary determinant of the relationship among personal, indoor, and outdoor particle levels.

A key finding of Sarnat, et al., is that while ambient PM2.5 concentrations are good surrogates for personal exposure to PM2.5 of ambient origin, ambient concentrations of gaseous air pollutants are not good surrogates of personal exposures to those gases. Rather, they are much better surrogates of personal exposure to PM2.5 of ambient origin. This indicates that reported associations of ambient gases with health outcomes in time series studies may need to be interpreted as effects of particles.

Future Activities:

We will continue to analyze data from these studies to investigate: (1) the contribution of particles of outdoor and indoor origin to personal PM2.5 exposures, (2) the potential for confounding by gaseous pollutants to affect epidemiological study results, and (3) the ability of particles to penetrate from outdoor to indoor environments. We also will continue to publish or submit papers addressing these issues for publication.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Publications Views
Other subproject views:	All 6 publications	6 publications in selected types	All 6 journal articles
Other center views:	All 207 publications	205 publications in selected types	All 204 journal articles

Publications
Type	Citation	Sub Project	Document Sources
Journal Article	Sarnat JA, Koutrakis P, Suh HH. Assessing the relationship between personal particulate and gaseous exposures of senior citizens living in Baltimore, MD. Journal of the Air & Waste Management Association 2000;50(7):1184-1198.	R827353 (Final) R827353C001 (2000) R827353C001 (2001) R827353C001 (2002) R827353C001 (2003) R827353C001 (2004) R827353C001 (Final)	Abstract from PubMed Full-text: Taylor&Francis-Full Text PDF Exit Abstract: Taylor&Francis-Abstract Exit

Supplemental Keywords:

particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., RFA, Health, Scientific Discipline, Air, particulate matter, Toxicology, Air Pollution Monitoring, Environmental Chemistry, air toxics, Epidemiology, Risk Assessments, Environmental Microbiology, Environmental Monitoring, Molecular Biology/Genetics, Atmospheric Sciences, indoor air, Biology, chemical exposure, ambient air quality, particulates, monitoring, particle size, risk assessment, sensitive populations, ambient air monitoring, cardiopulmonary responses, indoor exposure, human health effects, air pollutants, exposure and effects, lung, COPD, developmental effects, epidemelogy, respiratory disease, pulmonary disease, ambient measurement methods, ambient air, exposure, air pollution, particle exposure, children, ambient monitoring, ambient particle health effects, chronic effects, particulate exposure, inhalation, pulmonary, human exposure, inhalation toxicology, inhaled, PM, indoor air quality, cardiopulmonary, human health, genetic susceptibility, dosimetry, cardiovascular disease, human health risk, respiratory, measurement methods, exposure assessment

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/homeframe.htm Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.