Grantee Research Project Results
Publications Details for Grant Number R832414C001
Project 1 -- Pulmonary Metabolic Response
Other Views
- All
Publications - Selected
Publication Types - Journal
Articles - Publications Submitted
After Final Report - Redisplay this page without
Reference Title, Journal, and Author Columns - Display this Page
in RIS Format
| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Differential effect of low and high organic carbon content particulate matter in postnatal and adult rat airways. | None | Anderson DS, Chan JKW, Fanucchi MV, Van Winkle LS | Anderson DS, Chan JKW, Fanucchi MV, Van Winkle LS. Differential effect of low and high organic carbon content particulate matter in postnatal and adult rat airways. The Toxicologist 2010;114(S1):A1518. |
R832414 (Final) R832414C001 (2010) |
not available |
| Abstract | Development of adducted peptide biomarkers to address the consequences of human exposure to rodent pulmonary toxicants. | None | Buckpitt A, Pham N, Krawiec D, Morin D, Jewell W, Van Winkle L | Buckpitt A, Pham N, Krawiec D, Morin D, Jewell W, Van Winkle L. Development of adducted peptide biomarkers to address the consequences of human exposure to rodent pulmonary toxicants. The Toxicologist 2011;120(S-2):190 (abstract A888). |
R832414C001 (Final) |
|
| Abstract | Site-specific definition of acute airway epithelial injury following a single exposure to 1-nitronapthalene-coated carbon black particles. | THE TOXIOCOLOGIST | Fanucchi MV, Davison L, DeLong B, Plopper CG, Kennedy IM, Buckpitt AR | Fanucchi MV, Davison L, DeLong B, Plopper CG, Kennedy IM, Buckpitt AR. Site-specific definition of acute airway epithelial injury following a single exposure to 1-nitronapthalene-coated carbon black particles. The Toxiocologist 2006;90(1):A1026. |
R832414C001 (2006) |
not available |
| Abstract | Acute airway epithelial injury from three different carbon particles with and without adsorbed 1-nitronapthalene. | None | Fanucchi MV, Kumfer BM, Wallis ED, Kennedy IM | Fanucchi MV, Kumfer BM, Wallis ED, Kennedy IM. Acute airway epithelial injury from three different carbon particles with and without adsorbed 1-nitronapthalene. American Journal of Respiratory and Critical Care Medicine 2008;177 (abstract A425). |
R832414C001 (Final) |
not available |
| Abstract | A means to study critical adduct protein targets: comparison of toxic naphthalene and non-toxic diethyl maleate shows equivalent in vivo covalent binding and glutathione depletion in airway epithelium. | None | Krawiec D, Morin D, Van Winkle L, Buckpitt A | Krawiec D, Morin D, Van Winkle L, Buckpitt A. A means to study critical adduct protein targets: comparison of toxic naphthalene and non-toxic diethyl maleate shows equivalent in vivo covalent binding and glutathione depletion in airway epithelium. The Toxicologist 2011;120(S-2):392 (abstract A1832). |
R832414C001 (Final) |
|
| Abstract | Effects of post-natal ozone or particle exposure on the structural and functional differences in rat lungs. | None | Lee D, Schelegle E, Wallis C, Fanucchi MV, Van Winkle L, Plopper CG, Wexler AS | Lee D, Schelegle E, Wallis C, Fanucchi MV, Van Winkle L, Plopper CG, Wexler AS. Effects of post-natal ozone or particle exposure on the structural and functional differences in rat lungs. American Journal of Respiratory and Critical Care Medicine 2009;179:319 (abstract A2579). |
R832414C001 (2009) R832414C001 (Final) |
|
| Abstract | Structural and functional differences in rat lungs due to post-natal ozone or particle exposure. | None | Lee D, Schelegle E, Wallis C, Fanucchi M, Van Winkle L, Plopper C, Wexler A | Lee D, Schelegle E, Wallis C, Fanucchi M, Van Winkle L, Plopper C, Wexler A. Structural and functional differences in rat lungs due to post-natal ozone or particle exposure. The Toxicologist 2009;108(1):350 (abstract PS1687). |
R832414C001 (2009) R832414C001 (Final) |
|
| Abstract | Application of in vitro methods for studying oxidant stress in lung epithelium of multiple species. | None | Murphy SR, Chan JKW, Edwards PC, Van Winkle LS | Murphy SR, Chan JK, Edwards PC, Van Winkle LS. Application of in vitro methods for studying oxidant stress in lung epithelium of multiple species. Federation of American Societies for Experimental Biology 2010;24(Suppl):1001.19. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Abstract | Mechanisms of pulmonary tolerance in female mice to the cytotoxicant naphthalene. | None | Sutherland KM, Edwards PC, Van Winkle LS | Sutherland KM, Edwards PC, Van Winkle LS. Mechanisms of pulmonary tolerance in female mice to the cytotoxicant naphthalene. The FASEB Journal 2008;22(Suppl):918.4. |
R832414C001 (Final) |
|
| Abstract | Effect of inhaled soot on neonatal and adult rats. | None | Van Winkle LS, Edwards PC, Mathison JA, Sutherland KM, Chan JK, Mitchell VL, Anderson DS | Van Winkle LS, Edwards PC, Mathison JA, Sutherland KM, Chan JK, Mitchell VL, Anderson DS. Effect of inhaled soot on neonatal and adult rats. Molecular Biology of the Cell 2008;19(Suppl):164 (abstract 568/B520). |
R832414C001 (2009) R832414C001 (Final) |
|
| Abstract | Immune responses in neonatal and adult rats exposed to soot. | None | Van Winkle LS, Anderson DS, Edwards P, Chan J, Mathison J, Mitchell V | Van Winkle LS, Anderson DS, Edwards P, Chan J, Mathison J, Mitchell V. Immune responses in neonatal and adult rats exposed to soot. The Toxicologist 2009;108(1):433 (abstract PS2085). |
R832414C001 (2009) R832414C001 (Final) |
|
| Abstract | Microsomal epoxide hydrolase and airway sensitivity to the air pollutant naphthalene. | None | Van Winkle LS, Edwards PC, Chan JK, Sutherland KM, Anderson DM, Krawiecz D, Buckpitt AR | Van Winkle LS, Edwards PC, Chan JK, Sutherland KM, Anderson DM, Krawiecz D, Buckpitt AR. Microsomal epoxide hydrolase and airway sensitivity to the air pollutant naphthalene. American Journal of Respiratory and Critical Care Medicine 2009;179:F44 (abstract A3178). |
R832414C001 (2009) R832414C001 (Final) |
|
| Abstract | Sex differences in metabolism and toxicity in the lung. | None | Van Winkle LS, Sutherland K, Morin D, Edwards P, Buckpitt A | Van Winkle LS, Sutherland K, Morin D, Edwards P, Buckpitt A. Sex differences in metabolism and toxicity in the lung. The Toxicologist 2011;120(Suppl 2):190 (abstract A887). |
R832414C001 (Final) |
|
| Abstract | Differential effect of low and high organic carbon content particulate matter in postnatal and adult rat airways. | None | Van Winkle LS, Chan JK, Anderson DS, Fanucchi MV | Van Winkle LS, Chan JK, Anderson DS, Fanucchi MV. Differential effect of low and high organic carbon content particulate matter in postnatal and adult rat airways. The Toxicologist 2010;114(1):322 (abstract A1518). |
R832414C001 (Final) |
|
| Abstract | Metabolic basis of respiratory tract chemical toxicity. | None | Van Winkle LS, Ding X | Van Winkle LS, Ding X. Metabolic basis of respiratory tract chemical toxicity. The Toxicologist 2011;120(Suppl 2):189 (abstract A884). |
R832414C001 (Final) |
|
| Abstract | Oxidant Air Pollution and Childhood Asthma. | None | Van Winkle LS, Harkema JR | Van Winkle LS, Harkema JR. Oxidant air pollution and childhood asthma. The Toxicologist 2008;102(1):117 (abstract A568). |
R832414C001 (Final) |
|
| Abstract | Effects of postnatal exposure history on airways: use of airway explant cultures to evaluate responses to acute oxidant stress. | None | Van Winkle LS, Murphy SR, Edwards PC, Walby WF, Hyde DM, Schelegle ES | Van Winkle LS, Murphy SR, Edwards PC, Walby WF, Hyde DM, Schelegle ES. Effects of postnatal exposure history on airways: use of airway explant cultures to evaluate responses to acute oxidant stress. American Journal of Respiratory and Critical Care Medicine 2009;179:D47 (abstract A4976). |
R832414C001 (2009) R832414C001 (Final) |
|
| Book Chapter | Tracheobronchial airways. | None | Van Winkle LS, Smiley-Jewell S, Pinkerton KE | Van Winkle LS, Smiley-Jewell S, Pinkerton KE. Tracheobronchial airways. In:McQueen CA, ed. Comprehensive Toxicology (Second Edition). Amsterdam, The Netherlands: Elsevier Ltd., 2010, Volume 8, pp. 35-58. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Book Chapter | Cell damage and cell renewal in the lung. | None | Van Winkle LS | Van Winkle LS. Cell damage and cell renewal in the lung. In: McQueen CA, ed. Comprehensive Toxicology (Second Edition). Amsterdam, The Netherlands:Elsevier Ltd., 2010, Volume 8, pp. 223-242. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Journal Article | Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. | TOXICOLOGICAL SCIENCES | Chan JKW, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS | Chan JKW, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicological Sciences 2011;124(2):472-486. |
R832414 (Final) R832414C001 (Final) |
|
| Journal Article | Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Day KC, Plopper CG, Fanucchi MV | Day KC, Plopper CG, Fanucchi MV. Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 2006;291(1):L75-L83. |
R832414 (2009) R832414C001 (2007) R832414C001 (2008) R832414C001 (Final) |
|
| Journal Article | Airway trefoil factor expression during naphthalene injury and repair. | None | Greeley MA, Van Winkle LS, Edwards PC, Plopper CG | Greeley MA, Van Winkle LS, Edwards PC, Plopper CG. Airway trefoil factor expression during naphthalene injury and repair. Toxicological Sciences 2010;113(2):453-467. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Journal Article | The health effects of combustion-generated aerosols. | Proceedings of the Combustion Institute | Kennedy IM | Kennedy IM. The health effects of combustion-generated aerosols. Proceedings of the Combustion Institute 2007;31(2):2757-2770. |
R832414 (2009) R832414C001 (2008) R832414C001 (Final) |
|
| Journal Article | Inhaled particles disrupt postnatal airway development. | None | Lee DY, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JKW | Lee DY, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JKW. Small particles disrupt postnatal airway development. Journal of Applied Physiology 2010;109(4):1115-1124. |
R832414 (Final) R832414C001 (2010) R832414C005 (2010) R832414C005 (Final) |
|
| Journal Article | Site specific differences in gene expression of secreted proteins in the mouse lung:Comparison of methods to show differences by location. | None | Sutherland KM, Combs TJ, Edwards PC, Van Winkle LS | Sutherland KM, Combs TJ, Edwards PC, Van Winkle LS. Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location. Journal of Histochemistry and Cytochemistry 2010;58(12):1107-1119. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Journal Article | Sex differences in the development of airway epithelial tolerance to naphthalene. | AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Sutherland KM, Edwards PC, Combs TJ, Van Winkle LS | Sutherland KM, Edwards PC, Combs TJ, Van Winkle LS. Sex differences in the development of airway epithelial tolerance to naphthalene. American Journal of Physiology-Lung Cellular and Molecular Physiology 2012;302(1):L68-L81. |
R832414 (Final) R832414C001 (Final) |
|
| Journal Article | Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response. | None | Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV | Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV. Age specific responses to acute inhalation of diffusion flame soot particles:cellular injury and the airway antioxidant response. Inhalation Toxicology 2010;22(Suppl 2):70-83. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
|
| Presentation | Comparative pattern of immune responses in lung and peripheral blood following Inhalation of two different particle types. | None | Anderson DS, Chan JKW, Tablin F, Fanucchi MV, Van Winkle LS | Anderson DS, Chan JKW, Tablin F, Fanucchi MV, Van Winkle LS. Comparative pattern of immune responses in lung and peripheral blood following Inhalation of two different particle types. Presented at the 2010 American Association for Aerosol Research (AAAR) Air Pollution and Health Specialty Conference, Bridging the Gap From Sources to Health Outcomes, San Diego, CA, March 22-26, 2010. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
not available |
| Presentation | Temporal pattern in neonate and adult rats of inflammatory responses in lung and peripheral blood following inhalation of flame generated particulate matter. | None | Anderson DS, Chan JKW, Tablin F, Van Winkle LS. | Anderson DS, Chan JKW, Tablin F, Van Winkle LS. Temporal pattern in neonate and adult rats of inflammatory responses in lung and peripheral blood following inhalation of flame generated particulate matter. Presented at the Northern California chapter of the Society of Environmental Toxicology and Chemistry Annual Meeting, California State University, Sacramento, CA, May 4-5, 2011 (abstract A13, p24). |
R832414C001 (Final) |
not available |
| Presentation | Biomarkers of naphthalene toxicity. | None | Buckpitt AR | Buckpitt AR. Biomarkers of naphthalene toxicity. Presented at the 2009 Naphthalene Research Meeting of the Naphthalene Science Team, Davis, CA, June 2009. |
R832414C001 (2009) R832414C001 (Final) |
not available |
| Presentation | Combustion derived ultrafine particles differentially alter metabolic and antioxidant responses in neonatal and adult rats. | None | Chan J, Anderson D, Wallis C, Wexler A, Van Winkle LS. | Chan J, Anderson D, Wallis C, Wexler A, Van Winkle LS. Combustion derived ultrafine particles differentially alter metabolic and antioxidant responses in neonatal and adult rats. Presented at the Northern California Chapter of the Society of Environmental Toxicology and Chemistry Annual Meeting, California State University, Sacramento, CA, May 4-5, 2011 (abstract A10, p23). |
R832414C001 (Final) |
|
| Presentation | Structural and functional changes in rat lungs due to post-natal exposure to ozone with and without particles. | None | Lee D, Schelegle E, Wallis C, Fanucchi MV, Van Winkle L, Plopper CG, Wexler AS | Lee D, Schelegle E, Wallis C, Fanucchi MV, Van Winkle L, Plopper CG, Wexler AS. Structural and functional changes in rat lungs due to post-natal exposure to ozone with and without particles. Presented at the 2010 American Association for Aerosol Research (AAAR) Air Pollution and Health Specialty Conference, Bridging the Gap From Sources to Health Outcomes, San Diego, CA, March 22-26, 2010. |
R832414 (2010) R832414 (Final) R832414C001 (2010) R832414C001 (Final) R832414C005 (2010) R832414C005 (Final) |
not available |
| Presentation | Naphthalene toxicity and metabolism in the mEH knockout mouse (B6;129-Ephx1). | None | Van Winkle LS | Van Winkle LS. Naphthalene toxicity and metabolism in the mEH knockout mouse (B6;129-Ephx1). Lead roundtable discussion of Research Directions for Naphthalene. Presented at the 2008 Naphthalene Research Meeting, Storrs, CT, June 2008 (invited talk). |
R832414C001 (2008) R832414C001 (Final) |
not available |
| Presentation | Oxidant air pollution and childhood asthma. | None | Van Winkle LS | Van Winkle LS. Oxidant air pollution and childhood asthma. Presented at the Society of Toxicology 47th Annual Meeting & ToxExpo, Seattle, WA, March 16-20, 2008 (symposium chair and organizer). |
R832414C001 (2008) R832414C001 (Final) |
not available |
| Presentation | Comparative biology of the lung (continuing education course) and metabolism and enzymatic balance in the respiratory tract (presentation). | None | Van Winkle LS | Van Winkle LS. Comparative biology of the lung (continuing education course) and metabolism and enzymatic balance in the respiratory tract (presentation). Presented at the Society of Toxicology 49th Annual Meeting & ToxExpo, Salt Lake City, UT, March 7-11, 2010. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
not available |
| Presentation | Particle inhalation in postnatal and adult rats:expression of toxicity and oxidative stress associated genes in airways. | None | Van Winkle LS, Chan JKW, Anderson DS, Fanucchi MV | Van Winkle LS, Chan JKW, Anderson DS, Fanucchi MV. Particle inhalation in postnatal and adult rats: expression of toxicity and oxidative stress associated genes in airways. Presented at the 2010 American Association for Aerosol Research (AAAR) Air Pollution and Health Specialty Conference, Bridging the Gap From Sources to Health Outcomes, San Diego, CA, March 22-26, 2010. |
R832414 (Final) R832414C001 (2010) R832414C001 (Final) |
not available |
| Presentation | Site specific methods in the lung to improve toxicity testing. | None | Van Winkle LS | Van Winkle LS. Site specific methods in the lung to improve toxicity testing. Presented at the Hamner Institute, Research Triangle Park, NC, June 2011. |
R832414C001 (Final) |
not available |
| Presentation | Sex differences in metabolism and toxicity in the lung. | None | Van Winkle LS | Van Winkle LS. Sex differences in metabolism and toxicity in the lung. Presented at the Society of Toxicology 50th Annual Meeting & ToxExpo, Washington, DC, March 6-10, 2011. |
R832414C001 (Final) |
not available |
| Presentation | Ozone and the lung: biological effects during development. | None | Van Winkle LS | Van Winkle LS. Ozone and the lung: biological effects during development. Presented at the Sierra Ozone Summit, Holiday Inn Express, Grass Valley, CA, June 4, 2008 (invited talk). |
R832414C001 (2008) R832414C001 (Final) |
not available |
| Presentation | Pulmonary toxicity of naphthalene: lessons from animal studies. | None | Van Winkle LS | Van Winkle LS. Pulmonary toxicity of naphthalene: lessons from animal studies. Presented at the University of Arizona, Tuscon, AZ, January 2009 (invited). |
R832414C001 (2009) R832414C001 (Final) |
not available |
| Presentation | Research directions for naphthalene: are we ready to leave rodents behind? | None | Van Winkle LS | Van Winkle LS. Research directions for naphthalene: are we ready to leave rodents behind? Presented at the 2009 Naphthalene Research Meeting of the Naphthalene Science Team, Davis, CA, June 2009 (lead and moderated roundtable discussion). |
R832414C001 (2009) R832414C001 (Final) |
not available |
| Presentation | Genetic and environmental influences on injury and repair in the conducting airway. | None | Van Winkle LS | Van Winkle LS. Genetic and environmental influences on injury and repair in the conducting airway. Presented at the Johns Hopkins School of Public Health, Baltimore, MD, March 2009 (invited). |
R832414C001 (2009) R832414C001 (Final) |
not available |
| Presentation | Factors influencing respiratory tract chemical toxicity. | None | Van Winkle LS | Van Winkle LS. Factors influencing respiratory tract chemical toxicity. Presented at the Society of Toxicology 50th Annual Meeting & ToxExpo, Washington, DC, March 6-10, 2011. |
R832414C001 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.