Grantee Research Project Results
Final Report: Regional Cardiac Blood Flow with Air Particle Exposure
EPA Grant Number: R831917Title: Regional Cardiac Blood Flow with Air Particle Exposure
Investigators: Godleski, John J. , Okabe, Kazunori , Verrier, Richard
Institution: Beth Israel Deaconess Medical Center , Brigham and Women’s Hospital
EPA Project Officer: Chung, Serena
Project Period: August 1, 2004 through July 31, 2006
Project Amount: $473,924
RFA: The Role of Air Pollutants in Cardiovascular Disease (2003) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health , Particulate Matter , Air
Objective:
The specific aims of this grant are to:
(1) asess the mechanisms by which exposure to ambient particles exacerbates myocardial ischemia during acute coronary occlusion through assessment of regional myocardial blood flow.
(2) evaluate the role of the autonomic nervous system in regulation of regional myocardial blood flow with coronary occlusion and exposure to ambient particles.
Summary/Accomplishments (Outputs/Outcomes):
This overview lists the publications resulting from this grant and gives an overview of these publications. Publication number 1 is a review article by Dr. Godleski covering the mechanisms related to the effects of particulate air pollution on the heart and outlines novel approaches for these studies, including those used in this grant. Publications 2-6 are publications that deal with specific components in the ultimate experiments proposed in these studies that required technical development or adaptation to be used in these studies. Because of their complexity, these developments all merited publication and as can be seen these have been published, are in press, and only one remains in review. For these studies, blood pressure was a very important outcome and so important work was done on our large animal model in studies of blood pressure as an outcome, in assessment of mechanisms of blood pressure changes during exposure, and of the patho-physioloical basis of the change in blood pressure. These findings are detailed in paper number 7, which is a very significant contribution to the field of cardiovascular responses to air pollution and is still under review. Paper number 8 is one of the definitive studies of this grant and shows that with inhalation of particulate air pollution, total coronary vascular resistance increases by 13 and in areas of ischemia, by 33 percent. Total regional myocardial blood flow in ongoing myocardial ischemia is significantly decreased (p < .0001) with inhalation of concentrated ambient particles compared to filtered air, and blood flow is critically reduced in the areas of myocardial ischemia. This study suggests that short-term elevations in ambient air particles may render the coronary vasculature hyper-responsive. Therefore, patients with advanced coronary artery disease who experience recurrent myocardial ischemia are at risk that elevated air pollution may exacerbate ischemic episodes and precipitate myocardial infarction, malignant arrhythmia, and sudden cardiac death. These observations carry very important public health implications. Additional papers are expected from correlation of air particulate constituent data and the outcomes of paper 7 and 8.
References:
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- Godleski JJ. Responses of the Heart to Ambient Particle Inhalation. Clinics in Occupational and Environmental Medicine. 2006; 5:849-64.
- Bartoli CRG, Okabe K, Akiyama I, Verrier RL, Godleski JJ Technique for Implantation of Chronic Indwelling Aortic Access Catheters. J Investigative Surgery 2006: 19: 397-405.
- Bartoli CRG, Akiyama I, Godleski JJ, Verrier RL Long-term Pericardial Catheterization is Associated with Minimal Foreign-Body Response. Catheterization and Cardiovascular Intervention. 2007: 70(2):221-227
- Bartoli CRG, Okabe K, Akiyama I, Diaz EA, Godleski JJ Permanent Tracheostomy for Long-Term Respiratory Studies in Canines. Journal of Surgical Research. in press
- Bartoli CRG, Akiyama I Okabe K, Coull B, Godleski JJ Repeated Microsphere Delivery for Serial Measurement of Regional Blood Perfusion in the Chronically Instrumented, Conscious Canine. Journal of Surgical Research. in press
- Bartoli CRG and Godleski, JJ.Blood Flow in the Foreign-Body Capsules Surrounding Surgically Implanted Subcutaneous Devices (Submitted Biomaterials August 2007
- Bartoli CRG, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Katz T, Okabe K, Verrier RL, Godleski JJ. Mechanisms of particulate air pollution-induced arterial blood pressure changes. (Submitted J Hypertension, August 2007).
- Bartoli CRG, Akiyama I, Wellenius GA, Coull BA, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ. Acute Inhalation of Particulate Air Pollution Induces Inappropriate Coronary Vasoconstriction during Ongoing Myocardial Ischemia (Submitted- JAMA, Sept 2007)
Journal Articles on this Report : 10 Displayed | Download in RIS Format
| Other project views: | All 10 publications | 10 publications in selected types | All 10 journal articles |
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Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Okabe K, Verrier RL, Godleski JJ. Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes. Environmental Health Perspectives 2009;117(3):361-366. |
R831917 (Final) R832416 (Final) |
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Bartoli CR, Nadar MM, Godleski JJ. Capsule thickness correlates with vascular density and blood flow within foreign-body capsules surrounding surgically implanted subcutaneous devices. Artificial Organs 2010;34(10):857-861. |
R831917 (Final) R827353 (Final) R832416 (Final) R832416C003 (Final) |
Exit |
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Bartoli CR, Godleski JJ, Verrier RL. Mechanisms mediating adverse effects of air pollution on cardiovascular hemodynamic function and vulnerability to cardiac arrhythmias. Air Quality, Atmosphere & Health 2011;4(1):53-63. |
R831917 (Final) R827353 (Final) R832416 (Final) R832416C003 (Final) |
Exit Exit |
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Bartoli CRG, Wellenius GA, Coull BA, Akiyama I, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environmental Health Perspectives 2009;117(3):333-337. |
R831917 (Final) R827353 (Final) R832416 (Final) |
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Bartoli CRG, Okabe K, Akiyama I, Verrier RL, Godleski JJ. Technique for implantation of chronic indwelling aortic access catheters. Journal of Investigative Surgery 2006;19(6):397-405. |
R831917 (2005) R831917 (Final) |
Exit Exit |
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Bartoli CRG, Akiyama I, Godleski JJ, Verrier RL. Long-term pericardial catheterization is associated with minimum foreign-body response. Catheterization and Cardiovascular Interventions 2007;70(2):221-227. |
R831917 (2005) R831917 (Final) |
Exit Exit |
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Bartoli CRG, Akiyama I, Okabe K, Diaz EA, Godleski JJ. Permanent tracheostomy for long-term respiratory studies. Journal of Surgical Research 2008;145(1):124-129. |
R831917 (2005) R831917 (Final) |
Exit Exit |
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Bartoli CRG, Okabe K, Akiyama I, Coull B, Godleski JJ. Repeated microsphere delivery for serial measurement of regional blood perfusion in the chronically instrumented, conscious canine. Journal of Surgical Research 2008;145(1):135-141. |
R831917 (2005) R831917 (Final) |
Exit Exit Exit |
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Bartoli CRG, Godleski JJ. Blood flow in the foreign-body capsules surrounding surgically implanted subcutaneous devices. Journal of Surgical Research 2010;158(1):147-154. |
R831917 (Final) |
Exit Exit |
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Godleski JJ. Responses of the heart to ambient particle inhalation. Clinics in Occupational and Environmental Medicine 2006;5(4):849-864. |
R831917 (2005) R831917 (Final) |
Exit Exit |
Supplemental Keywords:
Ambient aerosol, lung injury, acute cardiovascular effects, long term exposure, lung disease, morbidity, airway disease, atherosclerosis, exposure, airborne particulate matter, cardiovascular vulnerability, blood viscosity, ambient particle health effects, concentrated air particles, cardiovascular disease, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, Toxicology, particulate matter, Health Risk Assessment, Risk Assessments, Physical Processes, ambient aerosol, lung injury, acute cardiovascular effects, long term exposure, lung disease, morbidity, airway disease, atherosclerosis, exposure, airborne particulate matter, cardiovascular vulnerability, blood viscosity, ambient particle health effects, concentrated air particles, cardiovascular diseaseProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.