Grantee Research Project Results
2000 Progress Report: Quantifying Exposure Error and its Effect on Epidemiological Studies
EPA Grant Number: R827353C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Quantifying Exposure Error and its Effect on Epidemiological Studies
Investigators: Suh, Helen H.
Current Investigators: Suh, Helen H. , Zanobetti, Antonella , Sarnat, Jeremy , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2000 through May 31, 2001
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air
Objective:
One of the objectives of this project is to improve our ability to characterize air pollutant exposures for health effects studies. This project is one of three research studies proposed under Theme I: Assessing Particle Exposures for Health Effects Studies that were based on personal, indoor, and outdoor particulate and gas concentrations that were measured as part of our previous or current exposure studies. This project was intended to address Particulate Matter Research Topic 10 identified by the National Research Council (NRC)- Analysis and Measurement. The main objective of this project is to quantify exposure error and to investigate its effect on the observed associations between exposure and health outcome.Progress Summary:
The preliminary findings of another project (see the 2000 Annual Report for R827353C001a) suggest that home characteristics, particularly home ventilation, are the primary determinant of the fraction of outdoor particles that penetrate indoor environments and thus are an important determinant of personal exposures to particles of outdoor origin as well. Through its impact on exposures to particles of outdoor origin, it is possible that home ventilation also may affect the association between outdoor particle concentrations and health risk. To test this hypothesis, we used data from 14 cities located across the United States to examine the relationship between air conditioning prevalence and the coefficient for the relationship between ambient PM10 concentrations and cause-specific hospital admissions (Janssen, et al., submitted). In addition, we examined whether observed variability in the risk coefficients was specifically related to PM10 emissions from mobile, combustion, and other sources. Results from this study indicate that air conditioning use explains a substantial amount of the variability in the risk coefficients from the different cities. Furthermore, PM10 emissions from mobile and diesel sources were also found to be important determinants of the variability in the risk coefficients, particularly for CVD-related hospital admissions.Future Activities:
In the next year, we will continue to investigate factors that affect relationships between personal exposures and outdoor concentrations and will use these data to examine their impact on epidemiological study results and to develop more refined exposure metrics for epidemiological studies.Journal Articles on this Report : 1 Displayed | Download in RIS Format
| Other subproject views: | All 3 publications | 3 publications in selected types | All 3 journal articles |
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| Other center views: | All 207 publications | 205 publications in selected types | All 204 journal articles |
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Janssen NAH, Schwartz J, Zanobetti A, Suh HH. Air conditioning and source-specific particles as modifiers of the effect of PM10 on hospital admissions for heart and lung disease. Environmental Health Perspectives 2002;110(1):43-49. |
R827353 (Final) R827353C002 (2000) R827353C002 (2001) R827353C002 (2002) R827353C002 (2003) R827353C002 (Final) |
Exit |
Supplemental Keywords:
particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., Health, RFA, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, tropospheric ozone, Environmental Microbiology, Molecular Biology/Genetics, indoor air, Toxicology, air toxics, epidemelogy, respiratory disease, air quality, health risks, Human Health Risk Assessment, indoor air quality, animal inhalation study, sensitive populations, health effects, human health, inhaled, biological mechanism , pulmonary disease, ambient monitoring, stratospheric ozone, respiratory, ambient air monitoring, indoor exposure, risk assessment, human exposure, measurement methods , measurement methods, pulmonary, genetic susceptibility, chemical exposure, particulate exposure, cardiopulmonary responses, dosimetry, atmospheric monitoring, monitoring, particulates, developmental effects, ambient particle health effects, exposure, PM, inhalation toxicology, inhaled particles, molecular epidemiology, ambient air, quantifying exposure error, air pollutants, air pollution, cardiovascular disease, human health risk, ambient air quality, human health effects, human susceptibility, cardiopulmonary, metals, particle exposure, cardiopulmonary response, interindividual variability, inhalation, ambient measurement methods, mortality studiesRelevant Websites:
http://www.hsph.harvard.edu/epacenter/homeframe.htm
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R827353 Health Effects Institute (2015 - 2020) Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological
Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards
Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to
Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate
Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition,
and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters,
Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.