Grantee Research Project Results

1999 Progress Report: Quantifying Exposure Error and its Effect on Epidemiological Studies

EPA Grant Number: R827353C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Quantifying Exposure Error and its Effect on Epidemiological Studies
Investigators: Suh, Helen H.
Current Investigators: Suh, Helen H. , Zanobetti, Antonella , Sarnat, Jeremy , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

The overall objective of this project is to improve our ability to characterize air pollutant exposures for health effects studies. This project is one of three research studies proposed under Theme I: Assessing Particle Exposures for Health Effects Studies that were based on personal, indoor, and outdoor particulate and gas concentrations that were measured as part of our previous or current exposure studies. This project was intended to address Particulate Matter Research Topic 10 identified by the National Research Council (NRC)- Analysis and Measurement.

Data from the Atlanta exposure and health study will be used to conduct this research project. We plan to use data collected in our Atlanta, GA, multi-pollutant exposure and cardiovascular health study to determine the effect of exposure error on observed health effects in time-series morbidity and mortality studies.

Progress Summary:

Data collection for our Atlanta, GA, multi-pollutant exposure and cardiovascular health study recently was completed, with sample analysis currently underway. In this study, we are assessing concentrations of specific particulate components in addition to the more traditional PM2.5 or PM10 measurements. For each study participant, for example, we measure simultaneously the personal exposures and indoor and outdoor concentrations of PM2.5, PM10, and gaseous co-pollutants (ozone, sulfur dioxide, and nitrogen dioxide) as before. In addition, we also are measuring personal, indoor, and outdoor concentrations of important particulate constituents, sulfate (SO42-), nitrate (NO3-), elemental carbon (EC), organic carbon (OC), and elements. These measurements are now possible due to the recent development of our multi-pollutant sampler, which allows simultaneous measurements to be made for varying combinations of PM2.5, PM10, SO42-, NO3-, EC/OC, elements, O3, SO2, and NO2 using a single sampling pump (Demokritou, et al., 2000).

Future Activities:

Data analysis will begin in the third year. The exposure error research is being conducted in conjunction with Paige Tolbert at Emory University Rollins School of Public Health, who is the principal investigator for a time-series morbidity study that was conducted for similar time periods in Atlanta.

Journal Articles:

No journal articles submitted with this report: View all 3 publications for this subproject

Supplemental Keywords:

particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., Health, RFA, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, tropospheric ozone, Environmental Microbiology, Molecular Biology/Genetics, indoor air, Toxicology, air toxics, epidemelogy, respiratory disease, air quality, health risks, Human Health Risk Assessment, indoor air quality, animal inhalation study, sensitive populations, health effects, human health, inhaled, biological mechanism , pulmonary disease, ambient monitoring, stratospheric ozone, respiratory, ambient air monitoring, indoor exposure, risk assessment, human exposure, measurement methods , measurement methods, pulmonary, genetic susceptibility, chemical exposure, particulate exposure, cardiopulmonary responses, dosimetry, atmospheric monitoring, monitoring, particulates, developmental effects, ambient particle health effects, exposure, PM, inhalation toxicology, inhaled particles, molecular epidemiology, ambient air, quantifying exposure error, air pollutants, air pollution, cardiovascular disease, human health risk, ambient air quality, human health effects, human susceptibility, cardiopulmonary, metals, particle exposure, cardiopulmonary response, interindividual variability, inhalation, ambient measurement methods, mortality studies

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/homeframe.htm Exit EPA icon

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.