Grantee Research Project Results

2002 Progress Report: Assessing Deposition of Ambient Particles in the Lung

EPA Grant Number: R827353C009
Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Assessing Deposition of Ambient Particles in the Lung
Investigators: Tsuda, Akira
Current Investigators: Godleski, John J. , Tsuda, Akira
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

The main objective of this research project is to use in situ continuous respiratory and total deposition measurement to develop a new regional deposition model.

Progress Summary:

Original Center activities focused on the development of theoretical models used to predict PM deposition as a function of size (Tsuda, et al., 2002). Subsequently, a series of human ambient particle deposition studies were conducted. The total deposition fraction of fine and ultra-fine aerosols was measured in a group of six healthy adults exposed to Boston ambient particles. The deposition efficiency of particles ranging from 40 to 2,045 nm was determined using the average concentration of inhaled and exhaled particles measured during these cycles. Deposition efficiencies ranged between 7.3 ± 18.7 percent (for particles 168-195 nm) and 98.6 ± 28.1 percent (for particles 1545-2045 nm). Subjects exhibited similar deposition patterns with a minimum efficiency in the size range of 100-200 nm. Results from ANOVA and mixed model regression analyses, suggested that deposition efficiency varied with individual and particle size. Deposition efficiencies varied mostly among subjects for particles in the size range between 100 and 1,000 nm.

References:

Lippman M, Frampton M, Schwartz J, Dockery DW, Schlesinger R, Koutrakis P, Froines J. The EPA's Particulate Matter (PM) Health Effects Research Centers Program: a mid-course (2 1/2 year) report of status, progress, and plans. Environmental Health Perspectives (in press, 2003).

Future Activities:

A manuscript has been submitted for publication (Montoya, et al., 2003). No additional deposition studies have been planned.

Journal Articles on this Report : 2 Displayed | Download in RIS Format

Publications Views
Other subproject views:	All 4 publications	4 publications in selected types	All 4 journal articles
Other center views:	All 207 publications	205 publications in selected types	All 204 journal articles

Publications
Type	Citation	Sub Project	Document Sources
Journal Article	Haber S, Yitzhak D, Tsuda A. Gravitational deposition in a rhythmically expanding and contracting alveolus. Journal of Applied Physiology 2003;95(2):657-671.	R827353 (Final) R827353C009 (2002) R827353C009 (Final)	Abstract from PubMed Full-text: JAP-Full Text PDF Exit Abstract: JAP-Abstract & Full Text HTML Exit
Journal Article	Henry FS, Butler JP, Tsuda A. Kinematically irreversible acinar flow:a departure from classical dispersive aerosol transport theories. Journal of Applied Physiology 2002;92(2):835-845.	R827353 (Final) R827353C009 (2002) R827353C009 (Final)	Abstract from PubMed Full-text: JAP-Full Text HTML Exit Abstract: JAP-Abstract Exit Other: JAP-Full Text PDF Exit

Supplemental Keywords:

ambient particles, air pollution, air pollutants, particulates, particulate matter, PM, fine particulates, PM2.5, lung deposition, ambient particle lung deposition, fine aerosols, ultrafine aerosols., Health, RFA, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, Environmental Microbiology, Molecular Biology/Genetics, indoor air, Toxicology, air toxics, air quality, health effects, health risks, Human Health Risk Assessment, indoor air quality, inhaled, sensitive populations, human health, epidemelogy, animal inhalation study, respiratory disease, ambient monitoring, pulmonary disease, stratospheric ozone, biological mechanism , human exposure, indoor exposure, respiratory, risk assessment, ambient air monitoring, cardiopulmonary responses, dosimetry, monitoring, pulmonary, genetic susceptibility, particulate exposure, chemical exposure, exposure, particulates, PM, developmental effects, ambient particle health effects, COPD, air pollutants, ambient air, inhaled particles, molecular epidemiology, toxics, inhalation toxicology, heart rate, air pollution, ambient air quality, cardiopulmonary, cardiovascular disease, human health effects, human health risk, metals, human susceptibility, ambient measurement methods, cardiopulmonary response, inhalation, interindividual variability, particle exposure

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/ Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.